This 331.8-mile journey from Biloxi to Friars Point, Mississippi, will take you approximately 7 hours and 14 minutes. It's a feasible day trip, though you might appreciate an early start to make the most of it. The primary roads guiding you are US 49 and US 49W, eventually transitioning to South Highway 61. With an estimated fuel cost of $50, this highway-focused drive offers a straightforward path through the Southeast region of Mississippi. Plan for about two stops along the way to break up the drive.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
165.9 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 3h 26m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 7h 14m. Total distance: 331.8 miles.
Family Friendly
Moderate complexity with 2 natural rest stops along the way.
Solo Traveler
7h 14m drive, plan rest stops for pacing.
Drive Character
Expect an 80% highway experience on this route, characterized by long stretches of open road. The longest continuous driving segment covers 140.6 miles, primarily on US 49, offering a chance to settle into a rhythm. While largely highway-focused, the transition to US 49W and then South Highway 61 may introduce slight changes in scenery and road conditions as you head further north. This drive prioritizes efficient travel over winding scenic byways.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 40 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 49 is the longest continuous segment at about 140.6 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on US 49 and US 49W. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 26 significant decision points across 331.8 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 158.9 miles (US 49): Highway fork - watch signs carefully.
Critical Maneuvers
5 of 26 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
5
25.5 mi into trip|~33m in|US 49
Merge onto US 49
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
5
158.9 mi into trip|~3h 17m in|US 49
Keep slight left at fork onto US 49 toward Jackson
Highway fork - watch signs carefully
Toward Jackson
6
162.2 mi into trip|~3h 21m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward I 20 West, US 49 North: Vicksburg, Yazoo City
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 West, US 49 North: Vicksburg, Yazoo...
5
164.9 mi into trip|~3h 25m in|US 49
Take the exit onto US 49 toward I 220 North, I 49 North: North Jackson, Yazoo City
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward I 220 North, I 49 North: North Jackson,...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and Friars Point, MS, road signs point toward Jackson, Yazoo City and Vicksburg.
Jackson
25.1 mi in|~32m
Yazoo City
162.2 mi in|~3h 21m|via I 20; US 49
Vicksburg
209.9 mi in|~4h 20m|via US 49W
Main Roads
Road
Distance
Duration
US 49
140.6 mi
2h 53m
US 49W
46.7 mi
56m
South Highway 61
43.9 mi
54m
Medgar Evers Boulevard
39.5 mi
48m
MS 15
20.7 mi
24m
North Sunflower Avenue
13.5 mi
23m
Stovall Road
6.5 mi
15m
I 20
4.3 mi
5m
Longest stretch:
US 49
— 140.6 mi, about 2h 53m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Friars Point, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Turn straight onto US 49
10 mi·16 min·US 49
Use the straight lane.
12
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
13
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
14
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
15
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
16
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
17
Take the exit onto US 49
0.2 mi·21 sec·US 49
18
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
19
Keep slight left at fork onto US 49
1.0 mi·1 min·US 49
20
Merge onto I 20; I 55; US 49
1.6 mi·2 min·I 20; I 55; US 49
21
Keep slight right at fork onto I 20; US 49
2.7 mi·3 min·I 20; US 49
Toward I 20 West, US 49 North: Vicksburg, Yazoo City
22
Take the exit onto US 49
5.2 mi·6 min·US 49
Toward I 220 North, I 49 North: North Jackson, Yazoo City
23
Take the exit onto US 49
0.3 mi·33 sec·US 49
Toward US 49 North: Yazoo City
24
Merge onto US 49
39 mi·48 min·Medgar Evers Boulevard
25
Take the exit onto US 49W
47 mi·56 min·US 49W
Toward US 49W North, MS 3 South: Indianola, Vicksburg
26
Turn left onto US 82
0.7 mi·1 min·US 82
27
Turn right onto MS 448
13 mi·23 min·North Sunflower Avenue
28
Turn left onto MS 448
1.1 mi·2 min·MS 448
29
Turn right onto US 61; US 278
44 mi·54 min·South Highway 61
30
Turn left onto MS 161
1.2 mi·2 min·MS 161
31
Turn left onto MS 322
1.4 mi·2 min·Sherard Road
32
Turn right onto West Lee Drive
1.0 mi·2 min·West Lee Drive
33
Turn left onto Stovall Road
6.5 mi·15 min·Stovall Road
34
Turn right onto MS 1
2.3 mi·3 min·Mississippi Highway 1
35
Turn slight left onto Friars Point Road
2.7 mi·6 min·Friars Point Road
36
At end of road, turn left onto South Street
246 ft·8 sec·South Street
37
Turn right onto Sheriff Ridge Avenue
0.6 mi·1 min·Sheriff Ridge Avenue
38
Continue on Washington Street
410 ft·13 sec·Washington Street
39
Turn right onto 3rd Street
506 ft·22 sec·3rd Street
40
Arrive at destination
2 ft·3rd Street
Trip Plan
To comfortably complete this 7-hour, 14-minute drive in one day, consider departing early in the morning. With two planned stops, you can allocate roughly 3.5 hours of driving time between each break. Keep an eye on your fuel levels, especially during the longest stretch of 140.6 miles on US 49, as services can be spaced out. The estimated fuel cost is around $50, so factor that into your budget. The flexibility of a single-day trip means you can adjust your stop durations as needed, but a consistent pace will help you arrive in Friars Point without feeling rushed.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 165.9 miles from Biloxi, MS, or about 3h 26m into the drive.
The longest continuous stretch on this route runs about 140.6 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 73 miles or 1h 30m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 165.9 miles or 3h 26m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 44m
Traffic, exits, and arrival timing usually matter more near Friars Point, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 331.8 miles and 7h 14m.
Your first comfortable stop window is around 73 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on US 49 for about 140.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 165.9 mi from Biloxi, MS
· 3h 26m into the drive
The midpoint is around 165.9 miles from Biloxi, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel check
Top up before US 49 if your tank is already low. That segment runs about 140.6 miles.
Arriving in Friars Point, MS
The final approach into Friars Point, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Friars Point, MS.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
3 mi from route
~8 min detour
Free
near mile 171.6
Emmett Till and Mamie Till-Mobley National Monument
National Monument
In 1955, 14-year-old Emmett Till traveled to Money, Mississippi, to visit relatives. He was kidnapped, tortured, and murdered after reportedly whistling at a white woman. His mother, Mamie Till-Mobley...
21 mi from route
~52 min detour
Free
near mile 308.9
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$50.11 one way
$100.22 round trip
$3.84/gal25.4 MPG avg116 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$55.01
$110.02
premium
$4.56
$59.55
$119.11
diesel
$5.61
$73.26
$146.51
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$50
Meals
$25–$50
Total
$75–$100
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 116.1 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $35 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
99.5
1
$34.84
$15.93
Efficient EV
83
0
$29.03
$13.27
EV Truck/SUV
132.7
1
$46.45
$21.24
Gas CO2
116 kg
EV CO2
39 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 14, 2026
Origin
Biloxi, MS
Late night
in Biloxi on Friday
Local time
4:41 AM
CDT
Current temp
77°F
Sunny
SE 10 mph0% chanceLive forecast
Destination
Friars Point, MS
Late night
in Friars Point on Friday
Local time
4:41 AM
CDT
Current temp
65°F
Mostly Clear
S 10 mph1% chanceLive forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
12 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
7h 14m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Biloxi, MS to Friars Point, MS covers 331.8 miles and takes about 7h 14m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 49, US 49W, South Highway 61. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 165.9 miles from Biloxi, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $50.11 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 2 meaningful breaks for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 26 significant decision points across 331.8 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 158.9 miles (US 49): Highway fork - watch signs carefully.
Between Biloxi, MS and Friars Point, MS, road signs point toward Jackson, Yazoo City and Vicksburg.
Yes. Nearby national parks include Medgar and Myrlie Evers Home National Monument and Emmett Till and Mamie Till-Mobley National Monument.
How this page is built
Compiled and maintained by the Trip.ovh planning team at COD Solutions Oy (Helsinki). Each route is built from authoritative open government and mapping datasets rather than crowdsourced reviews. Distances and geometry come from
OSRM
over
OpenStreetMap.
Fuel cost uses
EIA
weekly regional averages.
National park proximity is from the
NPS API.
Pages are published only after passing our data-quality checks; our
methodology page
documents refresh cadence, editorial standards, and known limitations.
