Drive Time
6h 55m
Distance
357.1 mi
575 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$55
one way
Photo: Bill Barber
Traversing Mississippi from the coast to the northern border is a substantial journey covering 357.1 miles. You should budget approximately 6 hours and 55 minutes of drive time, making this a long but manageable single-day trip for most drivers. With a fuel cost estimate of $55, it is an affordable way to cross the state. You will primarily utilize I-55, US 49, and MS 15 to navigate from the Southeast region toward the Memphis metropolitan area. Since this is a highway-focused drive, it is best suited for those looking to reach their destination efficiently rather than those seeking a leisurely backroads tour.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
178.6 miles from Biloxi, MS
A natural place for your longest stop of the day , about 3h 39m into the drive .
This trip is defined by its reliance on major thoroughfares, with 99% of the route consisting of highway driving. You will spend a significant portion of your time on the interstate, including a longest uninterrupted stretch of 193.7 miles along I-55. The personality of the road remains consistent and fast-paced, allowing you to maintain steady speeds throughout the trek. Because the route is so heavily prioritized for efficiency, you can expect a straightforward experience behind the wheel. Prepare for a predictable, high-speed transit that links the Gulf Coast to the northern reaches of the state.
This is a straightforward highway drive that stays mostly on I 55 and US 49. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Demanding - plan breaks and stay ahead of the key maneuvers
This is a demanding drive. With 15 significant decision points across 357.1 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 158.9 miles (US 49): Highway fork - watch signs carefully.
These are the spots where you need to pay the most attention. Preview them before you drive.
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Merge onto US 49
Merge point - match speed before joining. Lane positioning matters here
Keep slight left at fork onto US 49 toward Jackson
Highway fork - watch signs carefully
Take the exit toward Southaven, Horn Lake, Olive Branch
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Keep slight left at fork toward Memphis
Highway fork - watch signs carefully
On the drive from Biloxi, MS to Horn Lake, MS, road signs begin pointing toward Jackson along the way.
Jackson
| Road | Distance | Duration |
|---|---|---|
| I 55 | 193.7 mi | 3h 29m |
| US 49 | 135 mi | 2h 46m |
| MS 15 | 20.7 mi | 24m |
| I 110 | 3.1 mi | 4m |
| Goodman Road West | 2.1 mi | 3m |
| Hurt Road | 0.5 mi | 2m |
| Division Street | 0.5 mi | 1m |
| Main Street | 0.5 mi | 1m |
Step-by-step road directions between Biloxi, MS and Horn Lake, MS.
Start on Howard Avenue
Turn right onto Main Street
Turn left onto Division Street
Take the ramp onto Bohn Street
Turn straight
Merge onto I 110
Continue on MS 15; MS 67
Keep slight right at fork
Merge onto US 49
Continue on US 49
Turn straight onto US 49
Continue on US 49; MS 42
Continue on US 49
Continue on US 49
Continue on US 49
Continue on US 49
Take the exit onto US 49
Keep slight left at fork onto US 49
Keep slight right at fork onto US 49
Merge onto I 55
Take the exit
Keep slight left at fork
Turn left onto MS 302
Turn left onto Hurt Road
Turn right onto Camelot Road
Arrive at destination
To make the most of your 357.1-mile journey, try to depart early in the morning to avoid congestion as you approach the destination near Horn Lake. While the drive is feasible in one day, plan for at least one dedicated stop to stretch your legs and refuel. Keeping your budget around $55 for gas is a solid benchmark, but always check your vehicle's efficiency before heading out. Since you are spending nearly the entire duration on highways, stay alert during the long 193.7-mile stint on I-55 where fatigue can set in. Prioritizing consistent rest intervals will ensure you arrive safely after your seven-hour transit.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 41m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 178.6 miles or 3h 39m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 47m
Traffic, exits, and arrival timing usually matter more near Horn Lake, MS than in the middle of the route.
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 357.1 miles and 6h 55m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 178.6 mi from Biloxi, MS · 3h 39m into the drive
Mid-route town
Meal stop
179 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 80 miles helps settle the day before fatigue starts building.
The midpoint is around 178.6 miles from Biloxi, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before I 55 if your tank is already low. That segment runs about 193.7 miles.
The final approach into Horn Lake, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Horn Lake, MS.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$54.59 one way
$109.18 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.26 | $59.88 | $119.76 |
| premium | $4.61 | $64.81 | $129.62 |
| diesel | $5.64 | $79.34 | $158.67 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$55
Meals
$25–$50
Total
$80–$105
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 124.9 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $38 in charging · 1 stop · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 107.1 | 1 | $37.50 | $17.14 |
| Efficient EV | 89.3 | 1 | $31.25 | $14.28 |
| EV Truck/SUV | 142.8 | 1 | $49.99 | $22.85 |
Gas CO2
125 kg
EV CO2
42 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive. If you're planning ahead, check the forecast closer to your travel date.
Origin
Late night in Biloxi on Sunday
Local time
2:33 AM
CDT
Current temp
69°F
Forecast unavailable right now
Destination
Late night in Horn Lake on Sunday
Local time
2:33 AM
CDT
Current temp
64°F
Forecast unavailable right now
Along the Route
85°F
Magee, MS
179 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
Start early — leave by 6-7 AM to arrive at a reasonable hour.
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