The drive from Bluffton, SC to Florence, SC covers 166.2 miles and takes about 3h 12m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 95, Coosaw Scenic Drive, Lowcountry Drive for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 131.5 miles on I 95.
At current regular gas prices, budget about $25.99 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
83.1 miles from Bluffton, SC
A natural place for your longest stop of the day
, about 1h 38m into the drive
.