The drive from Booneville, MS to Greenville, MS covers 216.5 miles and takes about 4h 34m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on US 278, Pontotoc Parkway West, US 45 for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 126.7 miles on US 278.
At current regular gas prices, budget about $32.70 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
108.3 miles from Booneville, MS
A natural place for your longest stop of the day
, about 2h 14m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 34m. Total distance: 216.5 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 34m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (97%). Some complex stretches to watch for.
Drive Character
This is a 4h 34m highway drive covering 216.5 miles, with most of the trip on US 278 and Pontotoc Parkway West. The longest continuous stretch is about 126.7 miles on US 278.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 24 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 278 is the longest continuous segment at about 126.7 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on US 278 and Pontotoc Parkway West. You will hit about 15 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near MS 145 / North 2nd Street.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 216.5 miles you will encounter 15 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (MS 145 / North 2nd Street): Navigation decision point; at 3.2 miles (MS 30): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 37.3 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 15 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
4
0 mi into trip|~0m in|MS 145 / North 2nd Street
Turn left onto MS 145 / North 2nd Street
Navigation decision point
6
3.2 mi into trip|~5m in|MS 30
Keep slight left at fork onto MS 30 toward US 45 South, MS 30 West: Tupelo, New Albany
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 45 South, MS 30 West: Tupelo, New Alb...
6
37.3 mi into trip|~45m in
Take the exit toward MS 9 South: Sherman, Pontotoc
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 76--
Toward MS 9 South: Sherman, Pontotoc
5
37.7 mi into trip|~46m in|MS 9
Turn left onto MS 9
Lane positioning matters here
Use the straight lane.
7
47.5 mi into trip|~58m in
Take the exit toward US 278 West, MS 6 West: Oxford, University of Mississippi
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the right lane.
Toward US 278 West, MS 6 West: Oxford, Universi...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Booneville, MS and Greenville, MS, road signs point toward Pontotoc and University Of Mississippi.
Pontotoc
37.3 mi in|~45m
University Of Mississippi
47.5 mi in|~58m
Main Roads
Road
Distance
Duration
US 278
126.7 mi
2h 41m
Pontotoc Parkway West
29.8 mi
34m
US 45
18.4 mi
21m
MS 9
9.8 mi
11m
I 22
8.9 mi
9m
MS 182
8.7 mi
12m
MS 30
6.8 mi
8m
North 2nd Street
2.5 mi
4m
Longest stretch:
US 278
— 126.7 mi, about 2h 41m
Turn-by-Turn Driving Directions
Step-by-step road directions between Booneville, MS and Greenville, MS.
1
Start on Washington Street
28 ft·6 sec·Washington Street
2
Turn left onto MS 145
2.5 mi·4 min·North 2nd Street
3
Turn slight right
0.2 mi·45 sec
4
Turn straight onto MS 30
0.4 mi·31 sec·MS 30
5
Keep slight left at fork onto MS 30
6.4 mi·8 min·MS 30
Toward US 45 South, MS 30 West: Tupelo, New Albany
6
Continue on US 45
18 mi·21 min·US 45
7
Take the exit
0.5 mi·1 min
Toward US 78:west: Memphis
8
Merge onto I 22; US 78
8.9 mi·9 min·I 22; US 78
9
Take the exit
0.3 mi·43 sec
Exit 76--Toward MS 9 South: Sherman, Pontotoc
10
Turn slight left
131 ft·10 sec
11
Turn left onto MS 9
9.8 mi·11 min·MS 9
Use the straight lane.
12
Take the exit
0.3 mi·50 sec
Toward US 278 West, MS 6 West: Oxford, University of MississippiUse the right lane.
13
Merge onto US 278; MS 6
5.4 mi·6 min·Pontotoc Parkway West
14
Keep slight right at fork onto US 278; MS 6
24 mi·28 min·Pontotoc Parkway West
15
Continue on MS 6; US 278
0.5 mi·35 sec·MS 6; US 278
16
Continue on US 278; MS 6
62 mi·1 hr 22 min·US 278; MS 6
17
Take the exit onto US 278
65 mi·1 hr 19 min·US 278
18
Turn right onto Griffin Road
145 ft·7 sec·Griffin Road
19
Turn left onto Old Hwy 61
0.8 mi·1 min·Old Hwy 61
20
Turn straight onto North Broad Street
1.4 mi·2 min·North Broad Street
21
Turn right onto MS 182
8.7 mi·12 min·MS 182
22
Turn right onto South Main Street
0.9 mi·2 min·South Main Street
23
Turn right onto MS 814
10 ft·0 sec·South Broadway Street
24
Arrive at destination
MS 814
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 108.3 miles from Booneville, MS, or about 2h 14m into the drive.
The longest continuous stretch on this route runs about 126.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 48 miles or 59m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 108.3 miles or 2h 14m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 42m
Traffic, exits, and arrival timing usually matter more near Greenville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Booneville, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Booneville, MS
This is one driving day of about 216.5 miles and 4h 34m.
Your first comfortable stop window is around 48 miles from Booneville, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 278 for about 126.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 108.3 mi from Booneville, MS
· 2h 14m into the drive
The midpoint is around 108.3 miles from Booneville, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel check
Top up before US 278 if your tank is already low. That segment runs about 126.7 miles.
Arriving in Greenville, MS
The final approach into Greenville, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Greenville, MS.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
National Parks Near This Route
Worth a detour if your schedule allows.
Natchez Trace National Scenic Trail
National Scenic Trail
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
2 mi from route
~6 min detour
Free
near mile 29.9
Park Closure: Partial Closure of Rocky Springs Trail
Park Closure: Temporary Blackland Prairie Trail Closure to Equestrians
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
Emmett Till and Mamie Till-Mobley National Monument
National Monument
In 1955, 14-year-old Emmett Till traveled to Money, Mississippi, to visit relatives. He was kidnapped, tortured, and murdered after reportedly whistling at a white woman. His mother, Mamie Till-Mobley...
17 mi from route
~43 min detour
Free
near mile 141.9
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$32.70 one way
$65.39 round trip
$3.84/gal25.4 MPG avg76 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$35.89
$71.79
premium
$4.56
$38.86
$77.72
diesel
$5.61
$47.80
$95.60
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$33
Meals
$25–$50
Total
$58–$83
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 75.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $23 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
65
0
$22.73
$10.39
Efficient EV
54.1
0
$18.94
$8.66
EV Truck/SUV
86.6
1
$30.31
$13.86
Gas CO2
76 kg
EV CO2
25 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Booneville, MS
Night
in Booneville on Friday
Local time
11:13 PM
CDT
Current temp
77°F
Unavailable
Live forecast
Destination
Greenville, MS
Night
in Greenville on Friday
Local time
11:13 PM
CDT
Current temp
77°F
Unavailable
Live forecast
77°F
Batesville, MS
108 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
4h 34m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Booneville, MS to Greenville, MS covers 216.5 miles and takes about 4h 34m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 278, Pontotoc Parkway West, US 45. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 108.3 miles from Booneville, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $32.70 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This drive requires moderate attention. Across 216.5 miles you will encounter 15 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: near the start (MS 145 / North 2nd Street): Navigation decision point; at 3.2 miles (MS 30): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 37.3 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Between Booneville, MS and Greenville, MS, road signs point toward Pontotoc and University Of Mississippi.
Yes. Nearby national parks include Natchez Trace National Scenic Trail, Tupelo National Battlefield and Emmett Till and Mamie Till-Mobley National Monument.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.
