Origin
Cameron, MO
Evening in Cameron on Tuesday
Local time
6:46 PM
CDT
Current temp
50°F
Unavailable
Live forecast
Trip from Cameron, MO to Saint Charles, MO
Data updated 1 hour ago
Drive Time
5h 3m
Distance
250.2 mi
403 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$39
one way
EV Charging
Loading...
station data
Best Time to Leave
4 AM
4h 50m
★
6 AM
5h 4m
8 AM
5h 31m
10 AM
5h 13m
12 PM
5h 10m
3 PM
5h 14m
5 PM
5h 29m
8 PM
4h 56m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Cameron, MO
Wikimedia Commons
Saint Charles, MO
Wikimedia Commons
Trip Overview
The drive from Cameron, MO to Saint Charles, MO covers 250.2 miles and takes about 5h 3m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, Main Street for much of the mileage, and the overall profile is turn-heavy local drive. The longest uninterrupted segment is about 120.6 miles on Dwight D. Eisenhower Highway. At current regular gas prices, budget about $39.12 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
125.1 miles from Cameron, MO
A natural place for your longest stop of the day , about 2h 33m into the drive .
Loading map...
Drive Character
Expect a 5h 3m drive with frequent turns across 250.2 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 19 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Dwight D. Eisenhower Highway is the longest continuous segment at about 120.6 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. You will hit about 9 points where you need to pay attention to lane position or signs. The trickiest moment comes around 0.3 miles in near I 35 Business; US 69 / North Walnut Street.
Route Complexity
5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
This drive requires moderate attention. Across 250.2 miles you will encounter 9 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 0.3 miles (I 35 Business; US 69 / North Walnut Street): Navigation decision point; at 13.4 miles (MO 116): Roundabout - know your exit number before entering; at 69.1 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 9 key pointsThese are the spots where you need to pay the most attention. Preview them before you drive.
4
0.3 mi into trip
|
~1m in
|
I 35 Business; US 69 / North Walnut Street
At end of road, turn right onto I 35 Business; US 69 / North Walnut Street
Navigation decision point
4
13.4 mi into trip
|
~18m in
|
MO 116
Enter roundabout onto MO 116
Roundabout - know your exit number before entering
7
69.1 mi into trip
|
~1h 33m in
Take the exit toward I 70 East, US 40 East: Columbia
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward I 70 East, US 40 East: Columbia
8
247.9 mi into trip
|
~4h 57m in
Take the exit toward I 70 Business, MO 94: First Capitol Drive, Lewis and Clark Trail
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 228
Toward I 70 Business, MO 94: First Capitol Driv...
9
248 mi into trip
|
~4h 57m in
Keep slight left at fork toward I 70 Business, MO 94 East: First Capitol Drive, Lindenwood University, SSM Health Saint Joseph Hospital
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 70 Business, MO 94 East: First Capitol...
Main Roads
| Road | Distance | Duration |
|---|---|---|
| Dwight D. Eisenhower Highway | 120.6 mi | 2h 20m |
| U.S. Submarine Veterans' Memorial Highway | 54.4 mi | 58m |
| Main Street | 45.2 mi | 1h 1m |
| North Walnut Street | 13.1 mi | 17m |
| MO 116 | 10.6 mi | 13m |
| Sheriff Roger I. Wilson Memorial Highway | 1.9 mi | 2m |
| Highway Patrol Sgt. Benjamin Booth Memorial Highway | 1.6 mi | 1m |
| First Capitol Drive | 0.9 mi | 2m |
Longest stretch:
Dwight D. Eisenhower Highway
— 120.6 mi, about 2h 20m
Turn-by-Turn Driving Directions
Step-by-step road directions between Cameron, MO and Saint Charles, MO.
1
Start on West 2nd Street
0.3 mi
·
1 min
·
West 2nd Street
2
At end of road, turn right onto I 35 Business; US 69
13 mi
·
17 min
·
North Walnut Street
3
Enter roundabout onto MO 116
221 ft
·
3 sec
·
MO 116
4
Continue on MO 116
11 mi
·
13 min
·
MO 116
5
Turn right onto MO 13
45 mi
·
1 hr 1 min
·
Main Street
6
Take the exit
0.2 mi
·
23 sec
Toward I 70 East, US 40 East: Columbia
7
Merge onto I 70; US 40
20 mi
·
21 min
·
Dwight D. Eisenhower Highway
8
Continue on I 70; US 40
32 mi
·
34 min
·
U.S. Submarine Veterans' Memorial Highway
9
Keep slight left at fork onto I 70
22 mi
·
24 min
·
U.S. Submarine Veterans' Memorial Highway
10
Continue on I 70; US 40
1.8 mi
·
2 min
·
Dwight D. Eisenhower Highway
11
Continue on I 70; US 40
1.6 mi
·
1 min
·
Highway Patrol Sgt. Benjamin Booth Memorial Highway
12
Continue on I 70; US 40
1.9 mi
·
2 min
·
Sheriff Roger I. Wilson Memorial Highway
13
Continue on I 70; US 40
99 mi
·
1 hr 57 min
·
Dwight D. Eisenhower Highway
Use the straight / slight right lanes.
14
Take the exit
0.1 mi
·
14 sec
Exit 228
Toward I 70 Business, MO 94: First Capitol Drive, Lewis and Clark Trail
Use the slight right lane.
15
Keep slight left at fork
0.1 mi
·
14 sec
Toward I 70 Business, MO 94 East: First Capitol Drive, Lindenwood University, SSM Health Saint Joseph Hospital
Use the slight left / slight right lanes.
16
Turn straight onto I 70 Business; MO 94
0.9 mi
·
2 min
·
First Capitol Drive
17
Turn slight right onto I 70 Business; MO 94
0.9 mi
·
2 min
·
I 70 Business; MO 94
Toward MO 94
18
Turn left onto South Second Street
0.3 mi
·
56 sec
·
South Second Street
19
Arrive at destination
North Second Street
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 125.1 miles from Cameron, MO, or about 2h 33m into the drive.
The longest continuous stretch on this route runs about 120.6 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 45m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 125.1 miles or 2h 33m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 7m
Traffic, exits, and arrival timing usually matter more near Saint Charles, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Cameron, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Cameron, MO
This is one driving day of about 250.2 miles and 5h 3m.
Your first comfortable stop window is around 80 miles from Cameron, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 120.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 125.1 mi from Cameron, MO · 2h 33m into the drive
Mid-route town
Meal stop
125 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 80 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 125.1 miles from Cameron, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before Dwight D. Eisenhower Highway if your tank is already low. That segment runs about 120.6 miles.
Arriving in Saint Charles, MO
The final approach into Saint Charles, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Saint Charles, MO.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$39.12 one way
$78.23 round trip
$3.97/gal
25.4 MPG avg
88 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.36 | $42.95 | $85.90 |
| premium | $4.89 | $48.15 | $96.30 |
| diesel | $5.61 | $55.24 | $110.48 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$39
Meals
$25–$50
Total
$64–$89
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 87.5 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $26 in charging · 0 stops · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 75.1 | 0 | $26.27 | $12.01 |
| Efficient EV | 62.6 | 0 | $21.89 | $10.01 |
| EV Truck/SUV | 100.1 | 1 | $35.03 | $16.01 |
Gas CO2
88 kg
EV CO2
29 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Saint Charles, MO
Evening in Saint Charles on Tuesday
Local time
6:46 PM
CDT
Current temp
55°F
Unavailable
Live forecast
55°F
Quincy, IL
125 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
5 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 3m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Cameron, MO to Saint Charles, MO covers 250.2 miles and takes about 5h 3m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, Main Street. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 125.1 miles from Cameron, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $39.12 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This drive requires moderate attention. Across 250.2 miles you will encounter 9 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: at 0.3 miles (I 35 Business; US 69 / North Walnut Street): Navigation decision point; at 13.4 miles (MO 116): Roundabout - know your exit number before entering; at 69.1 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
The route from Cameron, MO to Saint Charles, MO does not surface many named destination signs beyond the main corridor.
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