The drive from Cape Girardeau, MO to Webb City, MO covers 338.7 miles and takes about 6h 33m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on US 60, Captain Aaron J Eidem Memorial Highway, US 61 for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 241.8 miles on US 60.
At current regular gas prices, budget about $52.95 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
169.4 miles from Cape Girardeau, MO
A natural place for your longest stop of the day
, about 3h 19m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 33m. Total distance: 338.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 33m drive, plan rest stops for pacing.
Drive Character
This is a 6h 33m highway drive covering 338.7 miles, with most of the trip on US 60 and Captain Aaron J Eidem Memorial Highway. The longest continuous stretch is about 241.8 miles on US 60.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 21 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 60 is the longest continuous segment at about 241.8 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on US 60 and Captain Aaron J Eidem Memorial Highway. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 2.9 miles in near I 55 Bus; US 61 / South Kingshighway.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 18 significant decision points across 338.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 2.9 miles (I 55 Bus; US 61 / South Kingshighway): Lane positioning matters here; at 4.8 miles (US 61): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 31.9 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 18 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
6
2.9 mi into trip|~5m in|I 55 Bus; US 61 / South Kingshighway
Turn left onto I 55 Bus; US 61 / South Kingshighway
Lane positioning matters here
Use the straight lane.
6
4.8 mi into trip|~8m in|US 61
Keep slight left at fork onto US 61 toward I 55 South, US 61 South: Sikeston
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 55 South, US 61 South: Sikeston
6
31.9 mi into trip|~37m in
Take the exit toward US 60 West: Dexter, Poplar Bluff
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 66B
Toward US 60 West: Dexter, Poplar Bluff
6
331.4 mi into trip|~6h 24m in|I 49; US 71
Take the exit onto I 49; US 71 toward I 49 South, US 71 South, MO 249 North: Neosho, Fort Smith
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 11
Toward I 49 South, US 71 South, MO 249 North: N...
6
331.7 mi into trip|~6h 24m in
Keep slight right at fork toward MO 249 North
Highway fork - watch signs carefully
Toward MO 249 North
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Cape Girardeau, MO and Webb City, MO, road signs point toward Poplar Bluff and Saint Louis.
Poplar Bluff
31.9 mi in|~37m
Saint Louis
83.4 mi in|~1h 37m|via US 60
Main Roads
Road
Distance
Duration
US 60
241.8 mi
4h 43m
Captain Aaron J Eidem Memorial Highway
56.3 mi
1h
US 61
27.2 mi
29m
Governor Warren E Hearnes Memorial Highway
5 mi
5m
South Kingshighway
1.9 mi
2m
Shawnee Parkway
1.6 mi
2m
North Sprigg Street
0.8 mi
1m
I 49 Business
0.6 mi
<1m
Longest stretch:
US 60
— 241.8 mi, about 4h 43m
Turn-by-Turn Driving Directions
Step-by-step road directions between Cape Girardeau, MO and Webb City, MO.
1
Start on Broadway Street
0.5 mi·55 sec·Broadway Street
2
Turn left onto MO 177
0.8 mi·1 min·North Sprigg Street
3
Turn right onto MO 34; MO 74
1.6 mi·2 min·Shawnee Parkway
Use the left lane.
4
Turn left onto I 55 Bus; US 61
1.9 mi·2 min·South Kingshighway
Use the straight lane.
5
Keep slight left at fork onto US 61
27 mi·29 min·US 61
Toward I 55 South, US 61 South: Sikeston
6
Take the exit
0.5 mi·1 min
Exit 66BToward US 60 West: Dexter, Poplar Bluff
7
Merge onto US 60
45 mi·52 min·US 60
8
Keep slight left at fork onto US 60
5.5 mi·6 min·US 60
9
Take the exit onto US 60
4.5 mi·6 min·US 60
Toward US 60 West, US 67 North: Springfield, Saint Louis
10
Take the exit onto US 60
186 mi·3 hr 38 min·US 60
11
Keep slight left at fork
0.8 mi·1 min
Toward I 44 West: Joplin
12
Merge onto I 44
56 mi·1 hr·Captain Aaron J Eidem Memorial Highway
13
Take the exit onto I 49; US 71
0.3 mi·24 sec·I 49; US 71
Exit 11Toward I 49 South, US 71 South, MO 249 North: Neosho, Fort Smith
14
Keep slight right at fork
0.2 mi·21 sec
Toward MO 249 North
15
Merge onto MO 249
5.0 mi·5 min·Governor Warren E Hearnes Memorial Highway
16
Take the exit
0.6 mi·38 sec
Toward I 49 Business, MO 171 North: Webb City
17
Merge onto I 49 Business; MO 171
0.6 mi·46 sec·I 49 Business; MO 171
Toward I 49 Business, MO 171 North: Webb City
18
Enter roundabout onto I 49 Business; MO 171
235 ft·3 sec·East MacArthur Drive
19
Continue on I 49 Business; MO 171
0.3 mi·27 sec·East MacArthur Drive
20
Turn right onto MO D
0.4 mi·39 sec·South Main Street
21
Arrive at destination
MO D
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 169.4 miles from Cape Girardeau, MO, or about 3h 19m into the drive.
The longest continuous stretch on this route runs about 241.8 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 75 miles or 1h 27m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 169.4 miles or 3h 19m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 28m
Traffic, exits, and arrival timing usually matter more near Webb City, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Cape Girardeau, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Cape Girardeau, MO
This is one driving day of about 338.7 miles and 6h 33m.
Your first comfortable stop window is around 75 miles from Cape Girardeau, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 60 for about 241.8 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 169.4 mi from Cape Girardeau, MO
· 3h 19m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Wilson's Creek National Battlefield
National Battlefield
Wilson's Creek was the first major Civil War battle fought west of the Mississippi River, and where the first Union general was killed in action. The costly Southern victory on August 10, 1861, focuse...
4 mi from route
~11 min detour
Free
near mile 268.7
The young child known as the "Plant Doctor" tended his secret garden while observing the day-to-day operations of a 19th century farm. Nature and nurture ultimately influenced George on his quest for...
7 mi from route
~16 min detour
Free
near mile 327.1
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$52.95 one way
$105.90 round trip
$3.97/gal25.4 MPG avg119 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$58.14
$116.28
premium
$4.89
$65.18
$130.36
diesel
$5.61
$74.78
$149.56
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$53
Meals
$25–$50
Total
$78–$103
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 118.5 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $36 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
101.6
1
$35.56
$16.26
Efficient EV
84.7
0
$29.64
$13.55
EV Truck/SUV
135.5
1
$47.42
$21.68
Gas CO2
119 kg
EV CO2
40 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 18, 2026
Origin
Cape Girardeau, MO
Morning
in Cape Girardeau on Saturday
Local time
10:10 AM
CDT
Current temp
81°F
Unavailable
Live forecast
Destination
Webb City, MO
Morning
in Webb City on Saturday
Local time
10:10 AM
CDT
Current temp
45°F
Chance Showers And Thunderstorms
N 18 mph42% chanceLive forecast
Flood Warning
Flood Warning issued April 18 at 2:43AM CDT by NWS St Louis MO
Flood Warning
Flood Warning issued April 18 at 2:07AM CDT until April 19 at 5:30PM CDT by NWS Springfield MO
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
36 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 33m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Cape Girardeau, MO to Webb City, MO covers 338.7 miles and takes about 6h 33m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 60, Captain Aaron J Eidem Memorial Highway, US 61. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 169.4 miles from Cape Girardeau, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $52.95 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 18 significant decision points across 338.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 2.9 miles (I 55 Bus; US 61 / South Kingshighway): Lane positioning matters here; at 4.8 miles (US 61): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 31.9 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Between Cape Girardeau, MO and Webb City, MO, road signs point toward Poplar Bluff and Saint Louis.
Yes. Nearby national parks include Wilson's Creek National Battlefield and George Washington Carver National Monument.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.
