Trip from Caruthersville, MO to Wentzville, MO

Drive Time

4h 11m

Distance

222 mi

357 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$34

one way

EV Charging

Loading...

station data

Best Time to Leave

Save up to 40 min
4 AM
3h 58m ★
6 AM
4h 11m
8 AM
4h 38m
10 AM
4h 20m
12 PM
4h 18m
3 PM
4h 22m
5 PM
4h 36m
8 PM
4h 3m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

city in and county seat of Pemiscot County, Missouri, United States

Caruthersville, MO

Wikimedia Commons

city in St. Charles County, Missouri, United States

Wentzville, MO

Wikimedia Commons

Trip Overview

The drive from Caruthersville, MO to Wentzville, MO covers 222 miles and takes about 4h 11m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.

The route leans on I 55, Avenue of the Saints, I 270 for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 175.7 miles on I 55. At current regular gas prices, budget about $33.72 one way before food or hotel costs.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

111 miles from Caruthersville, MO

A natural place for your longest stop of the day , about 2h 3m into the drive .

Drive Character

This is a 4h 11m highway drive covering 222 miles, with most of the trip on I 55 and Avenue of the Saints. The longest continuous stretch is about 175.7 miles on I 55.

Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 22 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 55 is the longest continuous segment at about 175.7 miles.

How Hard Is This Drive?

This is a straightforward highway drive that stays mostly on I 55 and Avenue of the Saints. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 5 miles in.

Route Complexity 9/10

High effort - long or complex enough to need steady focus all day

This is a demanding drive. With 17 significant decision points across 222 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: at 5 miles: Multiple destination signs - pick the right one; at 182.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 182.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.

Critical Maneuvers

5 of 17 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

6
5 mi into trip | ~9m in

Take the ramp toward I 55 North, US 61 North: Sikeston

Multiple destination signs - pick the right one

Toward I 55 North, US 61 North: Sikeston
8
182.3 mi into trip | ~3h 20m in

Take the exit toward I 270 West, I 255 East: Kansas City, Chicago

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Exit 196 Toward I 270 West, I 255 East: Kansas City, Chi...
8
182.5 mi into trip | ~3h 20m in

Keep slight left at fork toward I 270 West: Kansas City

Highway fork - watch signs carefully. Lane positioning matters here

Use the slight left lane. Toward I 270 West: Kansas City
8
194.8 mi into trip | ~3h 36m in

Take the exit toward I 64, US 40, US 61: Wentzville, Saint Louis

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Exit 12 Toward I 64, US 40, US 61: Wentzville, Saint Lo...
8
195 mi into trip | ~3h 36m in

Keep slight left at fork toward I 64 West, US 40 West, US 61 North: Wentzville

Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight left lane. Toward I 64 West, US 40 West, US 61 North: Went...

Towns Along This Route

Between Caruthersville, MO and Wentzville, MO, road signs point toward Chicago and Saint Louis.

Chicago

182.3 mi in | ~3h 20m

Saint Louis

194.8 mi in | ~3h 36m

Main Roads

Road Distance Duration
I 55 175.7 mi 3h 8m
Avenue of the Saints 25.6 mi 31m
I 270 11.5 mi 14m
West 3rd Street 2.9 mi 5m
MO 84 2 mi 3m
Rosa Parks Highway 1.3 mi 1m
East Pearce Boulevard 0.5 mi 1m
Luetkenhaus Boulevard 0.1 mi <1m
Longest stretch: I 55 — 175.7 mi, about 3h 8m

Turn-by-Turn Driving Directions

Step-by-step road directions between Caruthersville, MO and Wentzville, MO.

1

Start on this road

45 ft · 9 sec · this road
2

Turn left onto West 3rd Street

2.9 mi · 5 min · West 3rd Street
3

Continue on MO 84

2.0 mi · 3 min · MO 84
4

Take the ramp

0.3 mi · 32 sec
Toward I 55 North, US 61 North: Sikeston
5

Merge onto I 55; US 61

74 mi · 1 hr 19 min · I 55; US 61
6

Keep slight left at fork onto I 55

102 mi · 1 hr 49 min · I 55
7

Continue on I 55

1.3 mi · 1 min · Rosa Parks Highway
8

Take the exit

0.2 mi · 27 sec
Exit 196 Toward I 270 West, I 255 East: Kansas City, Chicago Use the slight right lane.
9

Keep slight left at fork

388 ft · 8 sec
Toward I 270 West: Kansas City Use the slight left lane.
10

Continue on this road

0.7 mi · 1 min · this road
Exit 196 Toward I 270 West
11

Merge onto I 270

11 mi · 14 min · I 270
Use the straight lane.
12

Take the exit

0.1 mi · 17 sec
Exit 12 Toward I 64, US 40, US 61: Wentzville, Saint Louis Use the slight right lane.
13

Keep slight left at fork

0.4 mi · 48 sec
Toward I 64 West, US 40 West, US 61 North: Wentzville Use the slight left lane.
14

Continue on this road

0.1 mi · 9 sec · this road
Exit 12 Toward I 64 West, US 40 West, US 61 North: Wentzville
15

Merge onto I 64; US 40; US 61

26 mi · 31 min · Avenue of the Saints
Use the straight lane.
16

Take the exit

0.2 mi · 24 sec
Toward Pitman Avenue Use the slight right lane.
17

Turn left onto Pitman Avenue

370 ft · 9 sec · Pitman Avenue
Use the left lane.
18

Turn right onto Luetkenhaus Boulevard

0.1 mi · 22 sec · Luetkenhaus Boulevard
19

Turn left onto East Pearce Boulevard

0.5 mi · 1 min · East Pearce Boulevard
Use the left lane.
20

Turn left onto North Elm Street

216 ft · 11 sec · North Elm Street
21

Turn right onto East Allen Street

201 ft · 8 sec · East Allen Street
22

Arrive at destination

East Allen Street

Trip Plan

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 111 miles from Caruthersville, MO, or about 2h 3m into the drive.
The longest continuous stretch on this route runs about 175.7 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 80 miles or 1h 30m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 111 miles or 2h 3m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 3h 20m

Traffic, exits, and arrival timing usually matter more near Wentzville, MO than in the middle of the route.

Before You Leave

+

Open the route before leaving Caruthersville, MO so your first major turns are already loaded.

+

Leave with enough water and a charging cable within reach, not packed away.

+

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Caruthersville, MO

This is one driving day of about 222 miles and 4h 11m.

Your first comfortable stop window is around 80 miles from Caruthersville, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 55 for about 175.7 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 111 mi from Caruthersville, MO · 2h 3m into the drive

archaeological site near East St. Louis, Illinois, USA

Mid-route town

Meal stop

Cahokia, IL

111 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Cambria, IL

Fuel and coffee

A short stop after about 80 miles helps settle the day before fatigue starts building.

Campton, IL

Meal break

The midpoint is around 111 miles from Caruthersville, MO, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before I 55 if your tank is already low. That segment runs about 175.7 miles.

Arriving in Wentzville, MO

The final approach into Wentzville, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Wentzville, MO.

After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$33.72 one way

$67.44 round trip

$3.86/gal 25.4 MPG avg 78 kg CO2
Fuel Type $/gal One Way Round Trip
midgrade $4.25 $37.17 $74.34
premium $4.80 $41.91 $83.82
diesel $5.64 $49.32 $98.64

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$34

Meals

$25–$50

Total

$59–$84

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 77.7 kg one way. Prices: EIA weekly data, 2026-04-06.

Driving Electric?

About $23 in charging · 0 stops · 67% less CO2

Vehicle Type kWh Stops DC Fast Home Charge
Average EV 66.6 0 $23.31 $10.66
Efficient EV 55.5 0 $19.42 $8.88
EV Truck/SUV 88.8 1 $31.08 $14.21

Gas CO2

78 kg

EV CO2

26 kg (67% less)

Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 3 days ago

Origin

Caruthersville, MO

Afternoon in Caruthersville on Monday

Local time

2:37 PM

CDT

Current temp

80°F

Unavailable

Live forecast

Destination

Wentzville, MO

Afternoon in Wentzville on Monday

Local time

2:37 PM

CDT

Current temp

53°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

27 degrees cooler at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

4h 11m on the road

An early start around 7-8 AM gets you there with plenty of daylight left.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Caruthersville, MO to Wentzville, MO covers 222 miles and takes about 4h 11m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 55, Avenue of the Saints, I 270. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 111 miles from Caruthersville, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $33.72 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 17 significant decision points across 222 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 5 miles: Multiple destination signs - pick the right one; at 182.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 182.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Between Caruthersville, MO and Wentzville, MO, road signs point toward Chicago and Saint Louis.

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