The drive from Cayce, SC to Myrtle Beach, SC covers 144.6 miles and takes about 3h 11m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Turbeville Highway, Garners Ferry Road, Highway 378 for much of the mileage,
and the overall profile is mixed drive.
The longest uninterrupted segment is about 36.1 miles on Turbeville Highway.
At current regular gas prices, budget about $22.61 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
72.3 miles from Cayce, SC
A natural place for your longest stop of the day
, about 1h 32m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 3h 11m. Total distance: 144.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
3h 11m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (31%). Some complex stretches to watch for.
Scenic Drive
Mixed drive route profile with national parks nearby.
Drive Character
The drive from Cayce, SC to Myrtle Beach, SC covers 144.6 miles and takes about 3h 11m, using a mix of highways and local roads.
Expect a mix of faster highway mileage and slower local approaches near the beginning or end.
There are about 24 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Turbeville Highway is the longest continuous segment at about 36.1 miles.
How Hard Is This Drive?
This route mixes highway mileage with some local-road sections near the start or finish. You will hit about 12 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near Glenn Street.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 144.6 miles you will encounter 12 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (Glenn Street): Navigation decision point; at 11.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 11.6 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 12 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
5
0 mi into trip|~0m in|Glenn Street
Turn right onto Glenn Street
Navigation decision point
8
11.5 mi into trip|~15m in
Take the exit toward US 76, US 378, SC 262: Garners Ferry Road, Leesburg Road
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 9A-B
Toward US 76, US 378, SC 262: Garners Ferry Roa...
10
11.6 mi into trip|~15m in
Keep slight right at fork toward US 76, US 378: Garners Ferry Road, Sumter
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 9 A
Toward US 76, US 378: Garners Ferry Road, Sumte...
6
11.9 mi into trip|~16m in|US 76; US 378 / Garners Ferry Road
Turn right onto US 76; US 378 / Garners Ferry Road
Lane positioning matters here
Use the right lane.
5
144.2 mi into trip|~3h 10m in|US 17 Business / North Kings Highway
Turn right onto US 17 Business / North Kings Highway
Navigation decision point
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Cayce, SC to Myrtle Beach, SC, road signs begin pointing toward Sumter along the way.
Sumter
11.6 mi in|~15m
Main Roads
Road
Distance
Duration
Turbeville Highway
36.1 mi
43m
Garners Ferry Road
34.6 mi
43m
Highway 378
22.9 mi
32m
Myrtle Beach Highway
13 mi
16m
Highway 501 East
10.7 mi
16m
Robert E Graham Freeway
6.4 mi
7m
William Earle Berne Beltway
5 mi
6m
Clarence Coker Highway
3.5 mi
4m
Longest stretch:
Turbeville Highway
— 36.1 mi, about 43m
Turn-by-Turn Driving Directions
Step-by-step road directions between Cayce, SC and Myrtle Beach, SC.
1
Start on Middleton Street
165 ft·8 sec·Middleton Street
2
Turn right onto Glenn Street
0.3 mi·56 sec·Glenn Street
3
Turn left onto US 21; US 176; US 321
2.7 mi·3 min·Charleston Highway
4
Take the ramp
0.8 mi·1 min
Toward I 77 North: Charlotte
5
Continue on I 77
2.7 mi·3 min·Veterans Memorial Freeway
6
Continue on I 77
5.0 mi·6 min·William Earle Berne Beltway
7
Take the exit
0.1 mi·19 sec
Exit 9A-BToward US 76, US 378, SC 262: Garners Ferry Road, Leesburg RoadUse the slight right lane.
8
Keep slight right at fork
0.2 mi·35 sec
Exit 9 AToward US 76, US 378: Garners Ferry Road, SumterUse the straight / slight right lanes.
9
Turn right onto US 76; US 378
35 mi·43 min·Garners Ferry Road
Use the right lane.
10
Keep slight left at fork onto US 76; US 378
6.4 mi·7 min·Robert E Graham Freeway
11
Continue on US 378
13 mi·16 min·Myrtle Beach Highway
12
Continue on US 378
3.5 mi·4 min·Clarence Coker Highway
13
Continue on US 301; US 378
0.5 mi·1 min·Main Street
14
Continue on US 301; US 378
36 mi·43 min·Turbeville Highway
15
Continue on US 378
23 mi·32 min·Highway 378
16
Continue on US 378
1.0 mi·2 min·Wright Boulevard
17
Turn right onto US 501; US 701
1.5 mi·2 min·Church Street
18
Continue on US 501
11 mi·16 min·Highway 501 East
Use the straight / slight right lanes.
19
Turn straight onto US 501
2.0 mi·3 min·US 501
Use the straight / right lanes.
20
Turn slight right onto 8th Avenue North
248 ft·14 sec·8th Avenue North
21
Turn right onto US 17 Business
0.3 mi·40 sec·North Kings Highway
22
Turn left onto 5th Avenue North
198 ft·11 sec·5th Avenue North
23
Turn right
196 ft·14 sec
24
Arrive at destination
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 72.3 miles from Cayce, SC, or about 1h 32m into the drive.
The longest continuous stretch on this route runs about 36.1 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 32 miles or 41m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 72.3 miles or 1h 32m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 30m
Traffic, exits, and arrival timing usually matter more near Myrtle Beach, SC than in the middle of the route.
Before You Leave
+
Open the route before leaving Cayce, SC so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Cayce, SC
This is one driving day of about 144.6 miles and 3h 11m.
Your first comfortable stop window is around 32 miles from Cayce, SC.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Turbeville Highway for about 36.1 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 72.3 mi from Cayce, SC
· 1h 32m into the drive
The midpoint is around 72.3 miles from Cayce, SC, which is a good place for a longer meal and fuel stop.
Arriving in Myrtle Beach, SC
The final approach into Myrtle Beach, SC usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Myrtle Beach, SC.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
National Parks Near This Route
Worth a detour if your schedule allows.
Congaree National Park
National Park
Astonishing biodiversity exists in Congaree National Park, the largest intact expanse of old growth bottomland hardwood forest remaining in the southeastern United States. Waters from the Congaree and...
10 mi from route
~26 min detour
Free
near mile 24.9
Caution: Backcountry Trail Conditions
Park Closure: Boardwalk Partially Closed for Construction
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$22.61 one way
$45.22 round trip
$3.97/gal25.4 MPG avg51 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.34
$24.72
$49.45
premium
$4.70
$26.76
$53.52
diesel
$5.61
$31.93
$63.85
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$23
Meals
$25–$50
Total
$48–$73
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 50.6 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $15 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
43.4
0
$15.18
$6.94
Efficient EV
36.2
0
$12.65
$5.78
EV Truck/SUV
57.8
0
$20.24
$9.25
Gas CO2
51 kg
EV CO2
17 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Cayce, SC
Morning
in Cayce on Friday
Local time
9:39 AM
EDT
Current temp
76°F
Unavailable
Live forecast
Destination
Myrtle Beach, SC
Morning
in Myrtle Beach on Friday
Local time
9:39 AM
EDT
Current temp
58°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
18 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
3h 11m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Cayce, SC to Myrtle Beach, SC covers 144.6 miles and takes about 3h 11m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Turbeville Highway, Garners Ferry Road, Highway 378. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 72.3 miles from Cayce, SC. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $22.61 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. A short stop every 2 to 3 hours is enough for this drive.
This drive requires moderate attention. Across 144.6 miles you will encounter 12 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: near the start (Glenn Street): Navigation decision point; at 11.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 11.6 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
On the drive from Cayce, SC to Myrtle Beach, SC, road signs begin pointing toward Sumter along the way.
Yes. Nearby national parks include Congaree National Park.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets —
OSRM
over
OpenStreetMap
for geometry@if($hasFuel),
EIA
for fuel prices@endif@if($hasWeather),
NOAA Climate Normals
for seasonal conditions@endif@if($hasElevation),
USGS 3DEP
for elevation@endif@if($hasEv),
NREL
for EV charging@endif@if($hasParks),
and NPS
for national parks@endif. See our
methodology
for refresh cadence and limitations.
