The drive from Cheyenne, WY to Buffalo, WY covers 289.4 miles and takes about 4h 42m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 25, South Main Street, Randall Avenue for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 286.3 miles on I 25.
At current regular gas prices, budget about $45.86 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
144.7 miles from Cheyenne, WY
A natural place for your longest stop of the day
, about 2h 21m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 42m. Total distance: 289.4 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
This is a 4h 42m highway drive covering 289.4 miles, with most of the trip on I 25 and South Main Street. The longest continuous stretch is about 286.3 miles on I 25.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 14 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 25 is the longest continuous segment at about 286.3 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 25 and South Main Street. There are only a few real navigation decisions along the way. The trickiest moment comes around 0.1 miles in near Carey Avenue.
Driving Effort3/10
Easy - simple navigation with a manageable amount of wheel time
Balances navigation complexity with total wheel time.
This is a straightforward 4h 42m drive. You will face about 6 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
The main spots that need attention: at 0.1 miles (Carey Avenue): Navigation decision point; at 1.1 miles (Hynds Boulevard): Navigation decision point; at 1.2 miles: Navigation decision point.
Critical Maneuvers
5 of 6 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
5
0.1 mi into trip|~0m in|Carey Avenue
Turn right onto Carey Avenue
Navigation decision point
3
1.1 mi into trip|~2m in|Hynds Boulevard
Turn right onto Hynds Boulevard
Navigation decision point
3
1.2 mi into trip|~2m in
Take the ramp
Navigation decision point
6
287.7 mi into trip|~4h 39m in
Take the exit toward I 25 Business, US 87 Business: Buffalo
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 298
Toward I 25 Business, US 87 Business: Buffalo
5
288.1 mi into trip|~4h 40m in|I 25 Bus; US 87 Bus / South Main Street
Turn left onto I 25 Bus; US 87 Bus / South Main Street
Lane positioning matters here
Use the straight lane.
Main Roads
Road
Distance
Duration
I 25
286.3 mi
4h 36m
South Main Street
1.3 mi
1m
Randall Avenue
0.9 mi
1m
Carey Avenue
0.1 mi
<1m
Hynds Boulevard
<0.1 mi
<1m
West 24th Street
<0.1 mi
<1m
North Main Street
—
—
Some road-level metrics are being recalculated.
Longest stretch:
I 25
— 286.3 mi, about 4h 36m
Turn-by-Turn Driving Directions
Step-by-step road directions between Cheyenne, WY and Buffalo, WY.
1
Start on West 24th Street
292 ft·12 sec·West 24th Street
2
Turn right onto Carey Avenue
0.1 mi·13 sec·Carey Avenue
3
Turn slight left onto Randall Avenue
0.9 mi·1 min·Randall Avenue
4
Turn right onto Hynds Boulevard
338 ft·5 sec·Hynds Boulevard
5
Take the ramp
0.2 mi·29 sec
6
Merge onto I 25; US 87
1.5 mi·1 min·I 25; US 87
7
Continue on I 25; US 85; US 87
3.9 mi·4 min·I 25; US 85; US 87
8
Continue on I 25; US 87
76 mi·1 hr 10 min·I 25; US 87
9
Continue on I 25; US 26; US 87
34 mi·31 min·I 25; US 26; US 87
10
Continue on I 25; US 20; US 26; US 87
62 mi·1 hr 5 min·I 25; US 20; US 26; US 87
11
Continue on I 25; US 87
109 mi·1 hr 42 min·I 25; US 87
12
Take the exit
0.4 mi·51 sec
Exit 298Toward I 25 Business, US 87 Business: Buffalo
13
Turn left onto I 25 Bus; US 87 Bus
1.3 mi·1 min·South Main Street
Use the straight lane.
14
Arrive at destination
I 25 Bus; US 16; US 87 Bus
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 144.7 miles from Cheyenne, WY, or about 2h 21m into the drive.
The longest continuous stretch on this route runs about 286.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 64 miles or 1h 2m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 144.7 miles or 2h 21m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 51m
Traffic, exits, and arrival timing usually matter more near Buffalo, WY than in the middle of the route.
Before You Leave
+
Open the route before leaving Cheyenne, WY so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Cheyenne, WY
This is one driving day of about 289.4 miles and 4h 42m.
Your first comfortable stop window is around 64 miles from Cheyenne, WY.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 25 for about 286.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 144.7 mi from Cheyenne, WY
· 2h 21m into the drive
Place data sourced from public business listings. Hours and availability may vary.
Fuel & Cost
Regular Gas
$45.86 one way
$91.72 round trip
$4.03/gal25.4 MPG avg101 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.22
$48.07
$96.14
premium
$4.53
$51.62
$103.25
diesel
$5.61
$63.90
$127.79
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$46
Meals
$25–$50
Total
$71–$96
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 101.3 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $30 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
86.8
1
$30.39
$13.89
Efficient EV
72.4
0
$25.32
$11.58
EV Truck/SUV
115.8
1
$40.52
$18.52
Gas CO2
101 kg
EV CO2
34 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Cheyenne, WY
Late night
in Cheyenne on Saturday
Local time
2:14 AM
MDT
Current temp
72°F
Unavailable
Live forecast
Destination
Buffalo, WY
Late night
in Buffalo on Saturday
Local time
2:14 AM
MDT
Current temp
69°F
Unavailable
Live forecast
46°F
Evansville, WY
145 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
3 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 42m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Cheyenne, WY to Buffalo, WY covers 289.4 miles and takes about 4h 42m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 25, South Main Street, Randall Avenue. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 144.7 miles from Cheyenne, WY. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $45.86 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a straightforward 4h 42m drive. You will face about 6 decision points, but nothing that requires special attention if you follow navigation.
The main spots that need attention: at 0.1 miles (Carey Avenue): Navigation decision point; at 1.1 miles (Hynds Boulevard): Navigation decision point; at 1.2 miles: Navigation decision point.
The route from Cheyenne, WY to Buffalo, WY does not surface many named destination signs beyond the main corridor.
