The drive from Des Moines, IA to Greene, IA covers 125.2 miles and takes about 2h 34m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 35, State Highway 3, Liberty Avenue for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 77.1 miles on I 35.
At current regular gas prices, budget about $19.57 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
62.6 miles from Des Moines, IA
A natural place for your longest stop of the day
, about 1h 10m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 2h 34m. Total distance: 125.2 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
This is a 2h 34m highway drive covering 125.2 miles, with most of the trip on I 35 and State Highway 3. The longest continuous stretch is about 77.1 miles on I 35.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 19 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 35 is the longest continuous segment at about 77.1 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 35 and State Highway 3. Navigation is very simple - set it and forget it for most of the drive. The trickiest moment comes around 0.1 miles in near East University Avenue.
Driving Effort2/10
Very easy - short and simple to drive
Balances navigation complexity with total wheel time.
The drive from Des Moines, IA to Greene, IA is easy. At 2h 34m with 80% highway, most drivers will find it relaxed and low-stress.
Where does it get tricky?
The main spots that need attention: at 0.1 miles (East University Avenue): Sharp turn - reduce speed on approach; at 1 miles: Multiple destination signs - pick the right one; at 1.8 miles (I 235 / John MacVicar Freeway): Merge point - match speed before joining. Lane positioning matters here.
Critical Maneuvers
5 of 9 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
7
0.1 mi into trip|~0m in|East University Avenue
Turn uturn onto East University Avenue
Sharp turn - reduce speed on approach
6
1 mi into trip|~2m in
Take the ramp toward US 69, East 14th Street, East 15th STreet
Multiple destination signs - pick the right one
Toward US 69, East 14th Street, East 15th STree...
5
1.8 mi into trip|~4m in|I 235 / John MacVicar Freeway
Merge onto I 235 / John MacVicar Freeway
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
5
83.7 mi into trip|~1h 33m in
Take the exit toward IA 3: Hampton, Clarion
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward IA 3: Hampton, Clarion
4
114.3 mi into trip|~2h 17m in|IA 14 / Liberty Avenue
Turn left onto IA 14 / Liberty Avenue
Navigation decision point
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Des Moines, IA to Greene, IA, road signs begin pointing toward Clarion along the way.
Clarion
83.7 mi in|~1h 33m
Main Roads
Road
Distance
Duration
I 35
77.1 mi
1h 23m
State Highway 3
17 mi
23m
Liberty Avenue
9.4 mi
13m
210th Street
9.2 mi
12m
John MacVicar Freeway
4.8 mi
5m
Central Avenue West
2.1 mi
4m
South Street
1.7 mi
2m
State Highway 14
0.7 mi
1m
Longest stretch:
I 35
— 77.1 mi, about 1h 23m
Turn-by-Turn Driving Directions
Step-by-step road directions between Des Moines, IA and Greene, IA.
1
Start on East University Avenue
481 ft·39 sec·East University Avenue
2
Turn uturn onto East University Avenue
0.5 mi·1 min·East University Avenue
3
Turn right onto US 69
0.4 mi·57 sec·East 14th Street
4
Take the ramp
0.8 mi·1 min
Toward US 69, East 14th Street, East 15th STreet
5
Merge onto I 235
4.8 mi·5 min·John MacVicar Freeway
Use the straight / slight right lanes.
6
Continue on I 35
77 mi·1 hr 23 min·I 35
Use the straight / slight right lanes.
7
Take the exit
0.5 mi·1 min
Toward IA 3: Hampton, Clarion
8
Turn right onto IA 3
8.9 mi·12 min·State Highway 3
9
Continue on IA 3
2.1 mi·4 min·Central Avenue West
10
Continue on IA 3
8.2 mi·11 min·State Highway 3
11
Continue on IA 3
1.8 mi·2 min·210th Street
12
Continue on IA 3
1.7 mi·2 min·South Street
13
Continue on IA 3
7.4 mi·10 min·210th Street
14
Turn left onto IA 14
9.4 mi·13 min·Liberty Avenue
15
Continue on IA 14
0.7 mi·1 min·State Highway 14
16
Turn right onto CR C13
0.2 mi·26 sec·West South Street
17
Continue on CR C13
0.5 mi·1 min·West Traer Street
18
Turn left onto North 1st Street
74 ft·1 sec·North 1st Street
19
Arrive at destination
North 1st Street
Trip Plan
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 62.6 miles from Des Moines, IA, or about 1h 10m into the drive.
The longest continuous stretch on this route runs about 77.1 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 28 miles or 33m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 62.6 miles or 1h 10m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 1m
Traffic, exits, and arrival timing usually matter more near Greene, IA than in the middle of the route.
Before You Leave
+
Open the route before leaving Des Moines, IA so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Des Moines, IA
This is one driving day of about 125.2 miles and 2h 34m.
Your first comfortable stop window is around 28 miles from Des Moines, IA.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 35 for about 77.1 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 62.6 mi from Des Moines, IA
· 1h 10m into the drive
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $13 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
37.6
0
$13.15
$6.01
Efficient EV
31.3
0
$10.96
$5.01
EV Truck/SUV
50.1
0
$17.53
$8.01
Gas CO2
44 kg
EV CO2
15 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Des Moines, IA
Night
in Des Moines on Thursday
Local time
11:58 PM
CDT
Current temp
52°F
Unavailable
Live forecast
Destination
Greene, IA
Night
in Greene on Thursday
Local time
11:58 PM
CDT
Current temp
47°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
5 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
2h 34m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Des Moines, IA to Greene, IA covers 125.2 miles and takes about 2h 34m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 35, State Highway 3, Liberty Avenue. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 62.6 miles from Des Moines, IA. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $19.57 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Leave by 9 AM and you'll arrive before lunch. Even a 4 PM departure gets you there before dark in summer.
Plan about 1 meaningful break for fuel, food, or rest. A short stop every 2 to 3 hours is enough for this drive.
The drive from Des Moines, IA to Greene, IA is easy. At 2h 34m with 80% highway, most drivers will find it relaxed and low-stress.
The main spots that need attention: at 0.1 miles (East University Avenue): Sharp turn - reduce speed on approach; at 1 miles: Multiple destination signs - pick the right one; at 1.8 miles (I 235 / John MacVicar Freeway): Merge point - match speed before joining. Lane positioning matters here.
On the drive from Des Moines, IA to Greene, IA, road signs begin pointing toward Clarion along the way.
