Traveling from Edwardsville to Pittsburgh covers 267.6 miles across Pennsylvania, connecting the Northeast region to the western part of the state. You should plan for about 5 hours and 32 minutes of driving time, making this a very manageable single-day trip. With a fuel budget of approximately $44, it is an affordable journey for a weekend getaway or a necessary commute. You will navigate via the Keystone Shortway, the William Penn Highway, and I-99 to reach your destination. Because the route is straightforward, you can easily complete it in one day without needing to book an overnight stay along the way.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
133.8 miles from Edwardsville, PA
A natural place for your longest stop of the day
, about 2h 36m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 32m. Total distance: 267.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 32m drive, comfortable solo distance.
Scenic Drive
Turn-heavy local drive route profile.
Drive Character
Expect a turn-heavy local drive that demands your full attention behind the wheel. Only 23% of this 267.6-mile trek takes place on major highways, meaning you will spend much of your time navigating local roads rather than cruising on an interstate. Your longest uninterrupted stretch occurs on the Keystone Shortway, which spans 98.5 miles of the journey. The experience shifts frequently, moving from faster highway segments to more technical, winding local sections. Be prepared for a varied pace that keeps the drive engaging as you transition between these different road types.
This route has more turning and local-road decision points than a simple highway run.
There are about 29 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Keystone Shortway is the longest continuous segment at about 98.5 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 2.6 miles in near South Main Street.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 17 significant decision points across 267.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 2.6 miles (South Main Street): Roundabout - know your exit number before entering; at 119 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 253.3 miles (I 376; US 22 / Penn-Lincoln Parkway East): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 17 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
6
2.6 mi into trip|~6m in|South Main Street
Enter roundabout onto South Main Street
Roundabout - know your exit number before entering
6
119 mi into trip|~2h 18m in
Take the exit toward I 99 South, US 220 South, PA 26: Bellefonte
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 161
Toward I 99 South, US 220 South, PA 26: Bellefo...
8
253.3 mi into trip|~5h 12m in|I 376; US 22 / Penn-Lincoln Parkway East
Keep slight right at fork onto I 376; US 22 / Penn-Lincoln Parkway East toward I 376 West, US 22 West: Pittsburgh
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Toward I 376 West, US 22 West: Pittsburgh
7
266.8 mi into trip|~5h 30m in
Take the exit toward Second Avenue
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Exit 71B
Toward Second Avenue
7
267.5 mi into trip|~5h 32m in|Grant Street
Turn right onto Grant Street
Lane positioning matters here
Use the right lane.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Edwardsville, PA and Pittsburgh, PA, road signs point toward Altoona and Hollidaysburg.
Altoona
143.5 mi in|~2h 48m|via I 99; US 220
Hollidaysburg
177.3 mi in|~3h 24m
Main Roads
Road
Distance
Duration
Keystone Shortway
98.5 mi
1h 47m
William Penn Highway
61.2 mi
1h 25m
I 99
33.8 mi
36m
Jacksonville Road
24.2 mi
28m
I 81
14.4 mi
16m
Penn-Lincoln Parkway East
13.5 mi
18m
Admiral Peary Highway
13.4 mi
19m
Market Street
1.2 mi
2m
Longest stretch:
Keystone Shortway
— 98.5 mi, about 1h 47m
Turn-by-Turn Driving Directions
Step-by-step road directions between Edwardsville, PA and Pittsburgh, PA.
1
Start on Jackson Street
0.3 mi·44 sec·Jackson Street
2
Continue on Main Street
0.7 mi·2 min·Main Street
3
Continue on Main Street
0.3 mi·52 sec·Main Street
4
Turn right onto Market Street
1.2 mi·2 min·Market Street
Use the straight / right lanes.
5
Continue on West Market Street
0.2 mi·26 sec·West Market Street
6
Enter roundabout onto South Main Street
322 ft·10 sec·South Main Street
7
Continue on South Main Street
0.7 mi·1 min·South Main Street
8
Turn left onto Hazle Street
1.0 mi·2 min·Hazle Street
9
Turn left onto Blackman Street
0.6 mi·1 min·Blackman Street
10
Turn right onto PA 309
0.2 mi·29 sec·Wilkes-Barre Township Boulevard
11
Take the ramp
0.3 mi·43 sec
12
Merge onto I 81
14 mi·16 min·I 81
13
Take the exit
0.7 mi·1 min
Exit 151BToward I-80 West: Bloomsburg
14
Merge onto I 80
99 mi·1 hr 47 min·Keystone Shortway
15
Take the exit
0.3 mi·53 sec
Exit 161Toward I 99 South, US 220 South, PA 26: Bellefonte
16
Turn left onto US 220; PA 26
24 mi·28 min·Jacksonville Road
Use the straight lane.
17
Keep slight left at fork onto I 99; US 220
34 mi·36 min·I 99; US 220
Toward I 99 South, US 220 South: Port Matilda, Altoona
18
Take the exit
0.8 mi·1 min
Toward US 22: Ebensburg, Hollidaysburg
19
Continue on this road
0.5 mi·43 sec·this road
20
Continue on US 22
16 mi·19 min·William Penn Highway
21
Continue on US 22
13 mi·19 min·Admiral Peary Highway
Use the straight lane.
22
Continue on US 22
45 mi·1 hr 6 min·William Penn Highway
Use the straight / right lanes.
23
Keep slight right at fork onto I 376; US 22
13 mi·18 min·Penn-Lincoln Parkway East
Toward I 376 West, US 22 West: PittsburghUse the slight left lane.
24
Take the exit
0.2 mi·38 sec
Exit 71BToward Second AvenueUse the straight / slight right lanes.
25
Turn straight onto Second Avenue
0.3 mi·41 sec·Second Avenue
26
At end of road, turn right onto Ross Street
0.2 mi·32 sec·Ross Street
27
Turn left onto Fifth Avenue
352 ft·10 sec·Fifth Avenue
28
Turn right onto Grant Street
513 ft·21 sec·Grant Street
Use the right lane.
29
Arrive at destination
Grant Street
Trip Plan
Since this is a one-day trip, your primary goal should be managing the 5-hour and 32-minute duration to avoid fatigue. With only one recommended stop, you have the flexibility to choose a location that fits your personal schedule rather than being constrained by a rigid itinerary. Keep an eye on your fuel gauge, as the technical nature of these local roads can sometimes impact your vehicle's efficiency differently than high-speed highway driving. To make the most of your time, try to depart early in the morning to navigate the turn-heavy portions of the route while traffic is lighter. Planning your single stop around the 150-mile mark will help you stay sharp for the final leg into Pittsburgh.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 133.8 miles from Edwardsville, PA, or about 2h 36m into the drive.
The longest continuous stretch on this route runs about 98.5 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 59 miles or 1h 13m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 133.8 miles or 2h 36m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 21m
Traffic, exits, and arrival timing usually matter more near Pittsburgh, PA than in the middle of the route.
Before You Leave
+
Open the route before leaving Edwardsville, PA so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Edwardsville, PA
This is one driving day of about 267.6 miles and 5h 32m.
Your first comfortable stop window is around 59 miles from Edwardsville, PA.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Keystone Shortway for about 98.5 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 133.8 mi from Edwardsville, PA
· 2h 36m into the drive
Place data sourced from public business listings. Hours and availability may vary.
Fuel & Cost
Regular Gas
$44.36 one way
$88.73 round trip
$4.21/gal25.4 MPG avg94 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.61
$48.59
$97.18
premium
$4.93
$51.90
$103.80
diesel
$5.61
$59.08
$118.17
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$44
Meals
$25–$50
Total
$69–$94
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 93.6 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $28 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
80.3
0
$28.10
$12.84
Efficient EV
66.9
0
$23.42
$10.70
EV Truck/SUV
107
1
$37.46
$17.13
Gas CO2
94 kg
EV CO2
31 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Edwardsville, PA
Late night
in Edwardsville on Saturday
Local time
4:16 AM
EDT
Current temp
43°F
Unavailable
Live forecast
Destination
Pittsburgh, PA
Late night
in Pittsburgh on Saturday
Local time
4:16 AM
EDT
Current temp
49°F
Unavailable
Live forecast
66°F
Tyrone, PA
134 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
6 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 32m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Edwardsville, PA to Pittsburgh, PA covers 267.6 miles and takes about 5h 32m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Keystone Shortway, William Penn Highway, I 99. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 133.8 miles from Edwardsville, PA. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $44.36 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 17 significant decision points across 267.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 2.6 miles (South Main Street): Roundabout - know your exit number before entering; at 119 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 253.3 miles (I 376; US 22 / Penn-Lincoln Parkway East): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Edwardsville, PA and Pittsburgh, PA, road signs point toward Altoona and Hollidaysburg.
