The drive from Enterprise, AL to Florence, AL covers 178.9 miles and takes about 3h 35m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 65, University of North Alabama Highway, County Road 24 for much of the mileage,
and the overall profile is mixed drive.
The longest uninterrupted segment is about 104.2 miles on I 65.
At current regular gas prices, budget about $27.02 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
89.4 miles from Enterprise, AL
A natural place for your longest stop of the day
, about 1h 46m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 3h 35m. Total distance: 178.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
3h 35m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (59%). Some complex stretches to watch for.
Scenic Drive
Mixed drive route profile with national parks nearby.
Drive Character
The drive from Enterprise, AL to Florence, AL covers 178.9 miles and takes about 3h 35m, using a mix of highways and local roads.
Expect a mix of faster highway mileage and slower local approaches near the beginning or end.
There are about 13 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 65 is the longest continuous segment at about 104.2 miles.
How Hard Is This Drive?
This route mixes highway mileage with some local-road sections near the start or finish. You will hit about 10 points where you need to pay attention to lane position or signs. The trickiest moment comes around 8.4 miles in near I 65.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 178.9 miles you will encounter 10 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 8.4 miles (I 65): Merge point - match speed before joining. Lane positioning matters here; at 112.7 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 168.3 miles (US 72 Alternate; AL 20; AL 157 / Wheeler Highway): Merge point - match speed before joining. Lane positioning matters here.
Critical Maneuvers
5 of 10 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
5
8.4 mi into trip|~17m in|I 65
Merge onto I 65
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
6
112.7 mi into trip|~2h 12m in
Take the exit toward AL 157: Cullman, Moulton
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 310
Toward AL 157: Cullman, Moulton
5
168.3 mi into trip|~3h 19m in|US 72 Alternate; AL 20; AL 157 / Wheeler Highway
Merge onto US 72 Alternate; AL 20; AL 157 / Wheeler Highway
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
5
172.5 mi into trip|~3h 24m in|US 43; US 72; AL 13; AL 17 / Woodward Avenue
Turn right onto US 43; US 72; AL 13; AL 17 / Woodward Avenue
Lane positioning matters here
Use the straight lane.
6
178.6 mi into trip|~3h 35m in|West Doctor Hicks Boulevard
Turn left onto West Doctor Hicks Boulevard
Lane positioning matters here
Use the left lane.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Enterprise, AL to Florence, AL, road signs begin pointing toward Moulton along the way.
Moulton
112.7 mi in|~2h 12m
Main Roads
Road
Distance
Duration
I 65
104.2 mi
1h 54m
University of North Alabama Highway
55.4 mi
1h 6m
County Road 24
5.5 mi
13m
Woodward Avenue
4.2 mi
7m
Wheeler Highway
4.2 mi
5m
7th Street South
2.7 mi
4m
US 43
1.8 mi
3m
South Pine Street
0.2 mi
<1m
Longest stretch:
I 65
— 104.2 mi, about 1h 54m
Turn-by-Turn Driving Directions
Step-by-step road directions between Enterprise, AL and Florence, AL.
1
Start on County Road 24
5.5 mi·13 min·County Road 24
2
Turn left onto US 31; AL 22
2.7 mi·4 min·7th Street South
3
Take the ramp
0.2 mi·27 sec
4
Merge onto I 65
104 mi·1 hr 54 min·I 65
Use the straight / slight right lanes.
5
Take the exit
0.2 mi·29 sec
Exit 310Toward AL 157: Cullman, Moulton
6
Turn left onto AL 157
200 ft·3 sec·Section Line Road
7
Continue on AL 157
55 mi·1 hr 6 min·University of North Alabama Highway
Use the straight lane.
8
Merge onto US 72 Alternate; AL 20; AL 157
4.2 mi·5 min·Wheeler Highway
Use the straight lane.
9
Turn right onto US 43; US 72; AL 13; AL 17
4.2 mi·7 min·Woodward Avenue
Use the straight lane.
10
Take the exit onto US 43; US 72; AL 13; AL 17; AL 20
1.8 mi·3 min·US 43; US 72; AL 13; AL 17; AL 20
Use the slight right lane.
11
Turn left onto West Doctor Hicks Boulevard
437 ft·15 sec·West Doctor Hicks Boulevard
Use the left lane.
12
Turn right onto South Pine Street
0.2 mi·34 sec·South Pine Street
13
Arrive at destination
North Pine Street
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 89.4 miles from Enterprise, AL, or about 1h 46m into the drive.
The longest continuous stretch on this route runs about 104.2 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 39 miles or 51m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 89.4 miles or 1h 46m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 53m
Traffic, exits, and arrival timing usually matter more near Florence, AL than in the middle of the route.
Before You Leave
+
Open the route before leaving Enterprise, AL so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Enterprise, AL
This is one driving day of about 178.9 miles and 3h 35m.
Your first comfortable stop window is around 39 miles from Enterprise, AL.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 65 for about 104.2 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 89.4 mi from Enterprise, AL
· 1h 46m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Birmingham Civil Rights National Monument
National Monument
In 1963, images of snarling police dogs unleashed against non-violent protesters and of children being sprayed with high-pressure hoses appeared in print and television news around the world. These dr...
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$27.02 one way
$54.04 round trip
$3.84/gal25.4 MPG avg63 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$29.66
$59.32
premium
$4.56
$32.11
$64.22
diesel
$5.61
$39.50
$79.00
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$27
Meals
$25–$50
Total
$52–$77
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 62.6 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $19 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
53.7
0
$18.78
$8.59
Efficient EV
44.7
0
$15.65
$7.16
EV Truck/SUV
71.6
0
$25.05
$11.45
Gas CO2
63 kg
EV CO2
21 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Enterprise, AL
Late night
in Enterprise on Friday
Local time
2:47 AM
CDT
Current temp
77°F
Unavailable
Live forecast
Destination
Florence, AL
Late night
in Florence on Friday
Local time
2:47 AM
CDT
Current temp
77°F
Unavailable
Live forecast
78°F
Hayden, AL
89 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
3h 35m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Enterprise, AL to Florence, AL covers 178.9 miles and takes about 3h 35m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 65, University of North Alabama Highway, County Road 24. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 89.4 miles from Enterprise, AL. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $27.02 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. A short stop every 2 to 3 hours is enough for this drive.
This drive requires moderate attention. Across 178.9 miles you will encounter 10 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: at 8.4 miles (I 65): Merge point - match speed before joining. Lane positioning matters here; at 112.7 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 168.3 miles (US 72 Alternate; AL 20; AL 157 / Wheeler Highway): Merge point - match speed before joining. Lane positioning matters here.
On the drive from Enterprise, AL to Florence, AL, road signs begin pointing toward Moulton along the way.
Yes. Nearby national parks include Birmingham Civil Rights National Monument.
Data sources
The figures on this page are computed from open government and mapping datasets, not crowdsourced reviews. Distances and geometry come from
OSRM
over
OpenStreetMap.
Fuel cost uses
EIA
weekly regional averages.
National park proximity is from the
NPS API.
Full methodology, refresh cadence, and limitations are documented on the
methodology page.
