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Trip from Excelsior Springs, MO to Cape Girardeau, MO

Drive Time

5h 18m

Distance

346.3 mi

557 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$53

one way

Downtown Excelsior Springs, MO, MO

Excelsior Springs, MO

Vika Glitter

Downtown Cape Girardeau, MO, MO

Cape Girardeau, MO

Craig Picariello

Trip Overview

The drive from Excelsior Springs, MO to Cape Girardeau, MO covers 346.3 miles and takes about 5h 18m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.

The route leans on Isley Boulevard, MO 13, MO 13 South for much of the mileage, and the overall profile is turn-heavy local drive. At current regular gas prices, budget about $52.60 one way before food or hotel costs.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

173.1 miles from Excelsior Springs, MO

A natural place for your longest stop of the day , about 2h 39m into the drive .

Drive Character

Expect a 5h 18m drive with frequent turns across 346.3 miles of local and secondary roads.

This route has more turning and local-road decision points than a simple highway run.
There are about 29 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Isley Boulevard is one of the defining roads on this drive.

How Hard Is This Drive?

Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. There are only a few real navigation decisions along the way.

Route Complexity 3/10

Easy - simple navigation with a manageable amount of wheel time

This is a straightforward 5h 18m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.

Where does it get tricky?

This route does not have any notably tricky sections. Most of the drive from Excelsior Springs, MO to Cape Girardeau, MO is straightforward, with well-signed roads and simple exits.

Main Roads

Road Distance Duration
Isley Boulevard Unavailable Refreshing
MO 13 Unavailable Refreshing
MO 13 South Unavailable Refreshing
South Spartan Drive Unavailable Refreshing
I 70 East Unavailable Refreshing
Dwight D Unavailable Refreshing
U Unavailable Refreshing
Highway Patrol Sgt Unavailable Refreshing

Per-road distance and duration are being refreshed from OSRM for this route.

Longest stretch: Isley Boulevard — detailed segment metrics are refreshing.

Turn-by-Turn Driving Directions

Step-by-step road directions between Excelsior Springs, MO and Cape Girardeau, MO.

1

Start on South Thompson Avenue

105 ft · 6 sec · South Thompson Avenue
2

Turn left onto Isley Boulevard

14 mi · 20 min · Isley Boulevard
3

Turn left

2.6 mi · 3 min
4

Take the exit slight right toward MO 13: Polo, Henrietta

0.3 mi · 38 sec · MO 13: Polo, Henrietta
5

Keep slight right to continue on MO 13 South: Henrietta

157 ft · 4 sec · MO 13 South: Henrietta
6

Merge slight left onto South Spartan Drive

25 mi · 30 min · South Spartan Drive
7

Take the exit left toward I 70 East, US 40 East: Columbia

0.2 mi · 23 sec · I 70 East, US 40 East: Columbia
8

Merge slight left onto Dwight D. Eisenhower Highway

20 mi · 21 min · Dwight D. Eisenhower Highway
9

Continue on U.S. Submarine Veterans' Memorial Highway

32 mi · 34 min · U.S. Submarine Veterans' Memorial Highway
10

Keep slight left to continue on U.S. Submarine Veterans' Memorial Highway

22 mi · 24 min · U.S. Submarine Veterans' Memorial Highway
11

Continue on Dwight D. Eisenhower Highway

1.8 mi · 2 min · Dwight D. Eisenhower Highway
12

Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway

1.6 mi · 1 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway
13

Continue on Sheriff Roger I. Wilson Memorial Highway

1.9 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway
14

Continue on Dwight D. Eisenhower Highway

81 mi · 1 hr 35 min · Dwight D. Eisenhower Highway
15

Take the exit slight right toward I 64 East, US 40 East, US 61 South: Chesterfield

0.3 mi · 33 sec · I 64 East, US 40 East, US 61 South: Chesterfield
16

Merge slight left onto Avenue of the Saints

25 mi · 30 min · Avenue of the Saints
17

Take the exit slight right toward I 270: Chicago, Memphis

0.3 mi · 39 sec · I 270: Chicago, Memphis
18

Keep slight right to continue on I 270 South: Memphis

0.3 mi · 31 sec · I 270 South: Memphis
19

Merge slight left

11 mi · 14 min
20

Take the exit slight right toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road

0.4 mi · 27 sec · I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
21

Keep slight right to continue on I 55 South: Memphis

0.4 mi · 44 sec · I 55 South: Memphis
22

Merge slight left onto Rosa Parks Highway

1.5 mi · 1 min · Rosa Parks Highway
23

Continue on Officer Thomas G. Smith, Jr. Memorial Highway

1.8 mi · 2 min · Officer Thomas G. Smith, Jr. Memorial Highway
24

Continue on Police Officer Steven Jarvis Memorial Highway

93 mi · 1 hr 39 min · Police Officer Steven Jarvis Memorial Highway
25

Take the exit slight right toward US 61, MO 34, I 55 Business: Cape Girardeau, Jackson

0.2 mi · 17 sec · US 61, MO 34, I 55 Business: Cape Girardeau, Jackson
26

Keep slight left to continue on I 55 Business, US 61 South, MO 34 East: Cape Girardeau

0.3 mi · 29 sec · I 55 Business, US 61 South, MO 34 East: Cape Girardeau
27

Continue on North Kingshighway

3.6 mi · 6 min · North Kingshighway
28

Turn left onto Broadway Street

2.0 mi · 3 min · Broadway Street
29

Arrive at your destination

Trip Plan

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 173.1 miles from Excelsior Springs, MO, or about 2h 39m into the drive.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 80 miles or 1h 13m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 173.1 miles or 2h 39m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 4h 23m

Traffic, exits, and arrival timing usually matter more near Cape Girardeau, MO than in the middle of the route.

Before You Leave

+

Open the route before leaving Excelsior Springs, MO so your first major turns are already loaded.

+

Leave with enough water and a charging cable within reach, not packed away.

+

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Excelsior Springs, MO

This is one driving day of about 346.3 miles and 5h 18m.

Your first comfortable stop window is around 80 miles from Excelsior Springs, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 173.1 mi from Excelsior Springs, MO · 2h 39m into the drive

Downtown Cahokia, IL, IL

Mid-route town

Meal stop

Cahokia, IL

173 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Quincy, IL

Fuel and coffee

A short stop after about 80 miles helps settle the day before fatigue starts building.

Cahokia, IL

Meal break

The midpoint is around 173.1 miles from Excelsior Springs, MO, which is a good place for a longer meal and fuel stop.

Arriving in Cape Girardeau, MO

The final approach into Cape Girardeau, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Cape Girardeau, MO.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$52.60 one way

$105.20 round trip

$3.86/gal 25.4 MPG avg 121 kg CO2
Fuel Type $/gal One Way Round Trip
midgrade $4.25 $57.98 $115.97
premium $4.80 $65.37 $130.75
diesel $5.64 $76.94 $153.87

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$53

Meals

$25–$50

Total

$78–$103

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 121.2 kg one way. Prices: EIA weekly data, 2026-04-06.

Driving Electric?

About $36 in charging · 1 stop · 66% less CO2

Vehicle Type kWh Stops DC Fast Home Charge
Average EV 103.9 1 $36.36 $16.62
Efficient EV 86.6 0 $30.30 $13.85
EV Truck/SUV 138.5 1 $48.48 $22.16

Gas CO2

121 kg

EV CO2

41 kg (66% less)

Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 2 days ago

Origin

Excelsior Springs, MO

Afternoon in Excelsior Springs on Sunday

Local time

2:34 PM

CDT

Current temp

51°F

Unavailable

Live forecast

Destination

Cape Girardeau, MO

Afternoon in Cape Girardeau on Sunday

Local time

2:34 PM

CDT

Current temp

74°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

23 degrees warmer at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

5h 18m on the road

An early start around 7-8 AM gets you there with plenty of daylight left.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Excelsior Springs, MO to Cape Girardeau, MO covers 346.3 miles and takes about 5h 18m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Isley Boulevard, MO 13, MO 13 South. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 173.1 miles from Excelsior Springs, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $52.60 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a straightforward 5h 18m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.
This route does not have any notably tricky sections. Most of the drive from Excelsior Springs, MO to Cape Girardeau, MO is straightforward, with well-signed roads and simple exits.
The route from Excelsior Springs, MO to Cape Girardeau, MO does not surface many named destination signs beyond the main corridor.

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