The drive from Gulfport, MS to Greenwood, MS covers 304.2 miles and takes about 6h 20m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on US 45, Lance Corporal Roy M Wheat Memorial Highway, 25th Avenue for much of the mileage,
and the overall profile is mixed drive.
The longest uninterrupted segment is about 106.1 miles on US 45.
At current regular gas prices, budget about $45.94 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
152.1 miles from Gulfport, MS
A natural place for your longest stop of the day
, about 2h 55m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 20m. Total distance: 304.2 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 20m drive, plan rest stops for pacing.
Scenic Drive
Mixed drive route profile with national parks nearby.
Drive Character
The drive from Gulfport, MS to Greenwood, MS covers 304.2 miles and takes about 6h 20m, using a mix of highways and local roads.
Expect a mix of faster highway mileage and slower local approaches near the beginning or end.
There are about 32 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 45 is the longest continuous segment at about 106.1 miles.
How Hard Is This Drive?
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 65.3 miles in near US 98.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 17 significant decision points across 304.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 65.3 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 154.5 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 163.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Critical Maneuvers
5 of 17 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
7
65.3 mi into trip|~1h 20m in|US 98
Take the exit onto US 98 toward I 59 North, US 98 West: Columbia, Laurel
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 59 North, US 98 West: Columbia, Laurel
8
154.5 mi into trip|~2h 58m in|I 59
Keep slight right at fork onto I 59 toward I 59 North, I 20 East: Meridian, Tuscaloosa
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Toward I 59 North, I 20 East: Meridian, Tuscalo...
6
163.5 mi into trip|~3h 8m in
Take the exit toward US 45 North: Macon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Toward US 45 North: Macon
6
228.8 mi into trip|~4h 23m in|US 45
Keep slight right at fork onto US 45 toward US 45 North: Columbus, Aberdeen
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 45 North: Columbus, Aberdeen
6
246.6 mi into trip|~4h 44m in
Take the exit toward US 82 East, US 45 North, MS 12 East: Columbus
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward US 82 East, US 45 North, MS 12 East: Col...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Gulfport, MS and Greenwood, MS, road signs point toward Laurel, Tuscaloosa and Aberdeen.
Laurel
65.3 mi in|~1h 20m|via US 98
Tuscaloosa
154.5 mi in|~2h 58m|via I 59
Aberdeen
228.8 mi in|~4h 23m|via US 45
Main Roads
Road
Distance
Duration
US 45
106.1 mi
2h 4m
Lance Corporal Roy M Wheat Memorial Highway
88.4 mi
1h 35m
25th Avenue
60.1 mi
1h 14m
State Highway 371
10.1 mi
17m
I 59
9 mi
10m
MS 8
6.5 mi
9m
Highway 125
5.2 mi
9m
Dorsey Evergreen Road
4.3 mi
16m
Longest stretch:
US 45
— 106.1 mi, about 2h 4m
Turn-by-Turn Driving Directions
Step-by-step road directions between Gulfport, MS and Greenwood, MS.
1
Start on US 49
60 mi·1 hr 14 min·25th Avenue
Use the straight lane.
2
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
3
Take the exit
0.3 mi·51 sec
4
Merge onto US 98
2.5 mi·2 min·US 98
Use the straight / slight right lanes.
5
Take the exit onto US 98
0.8 mi·1 min·US 98
Toward I 59 North, US 98 West: Columbia, LaurelUse the straight / slight right lanes.
6
Merge onto I 59; US 98
88 mi·1 hr 35 min·Lance Corporal Roy M Wheat Memorial Highway
Use the straight / slight right lanes.
7
Keep slight right at fork onto I 59
9.0 mi·10 min·I 59
Toward I 59 North, I 20 East: Meridian, TuscaloosaUse the straight lane.
8
Take the exit
0.3 mi·47 sec
Toward US 45 North: MaconUse the slight right lane.
9
Merge onto US 45
65 mi·1 hr 14 min·US 45
Use the straight lane.
10
Keep slight right at fork onto US 45
3.4 mi·4 min·US 45
Toward US 45 North: Columbus, Aberdeen
11
Continue on US 45
14 mi·16 min·US 45
12
Continue on Plymouth Bluff Access Road
312 ft·5 sec·Plymouth Bluff Access Road
Use the straight / slight right lanes.
13
Take the exit
3.9 mi·4 min
Toward US 82 East, US 45 North, MS 12 East: Columbus
14
Take the exit onto US 45
0.5 mi·55 sec·US 45
Toward US 45 North: AberdeenUse the slight right lane.
15
Continue on US 45; MS 50
13 mi·16 min·US 45; MS 50
Use the left lane.
16
Continue on US 45
2.0 mi·2 min·US 45
17
Continue on US 45
1.9 mi·2 min·US 45
18
Continue on US 45
1.8 mi·2 min·US 45
19
Continue on US 45
0.8 mi·55 sec·US 45
20
Continue on US 45
2.2 mi·2 min·US 45
21
Continue on US 45
0.8 mi·52 sec·US 45
22
Continue on US 45
0.3 mi·17 sec·US 45
23
Take the exit
0.3 mi·50 sec
Toward MS 25 North, MS 8 East: Amory
24
Continue on MS 8; MS 25
6.5 mi·9 min·MS 8; MS 25
25
Turn left onto Highway 125
5.2 mi·9 min·Highway 125
26
Turn right onto US 278
0.4 mi·59 sec·US 278
27
Turn left onto MS 25
1.1 mi·2 min·South Main Street
Use the left lane.
28
Turn left onto MS 6
2.5 mi·4 min·State Highway 6
29
Turn right onto MS 371
10 mi·17 min·State Highway 371
30
Turn right onto Dorsey Evergreen Road
4.3 mi·16 min·Dorsey Evergreen Road
31
Turn sharp left onto Greenwood Hopewell Road
145 ft·6 sec·Greenwood Hopewell Road
32
Arrive at destination
Greenwood Hopewell Road
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 152.1 miles from Gulfport, MS, or about 2h 55m into the drive.
The longest continuous stretch on this route runs about 106.1 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 67 miles or 1h 23m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 152.1 miles or 2h 55m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 48m
Traffic, exits, and arrival timing usually matter more near Greenwood, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Gulfport, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Gulfport, MS
This is one driving day of about 304.2 miles and 6h 20m.
Your first comfortable stop window is around 67 miles from Gulfport, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 45 for about 106.1 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 152.1 mi from Gulfport, MS
· 2h 55m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Tupelo National Battlefield
National Battlefield
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
13 mi from route
~33 min detour
Free
near mile 304.2
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
14 mi from route
~34 min detour
Free
near mile 304.2
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$45.94 one way
$91.88 round trip
$3.84/gal25.4 MPG avg106 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$50.43
$100.87
premium
$4.56
$54.60
$109.20
diesel
$5.61
$67.16
$134.33
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$46
Meals
$25–$50
Total
$71–$96
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 106.4 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
6 DC fast chargers
· Coverage: good
Tesla Destination Charger
Gulfport, Mississippi
Tesla Destination
1 DCFC
Pilot Charging Station
Gulfport, Mississippi
Other
1 DCFC
Tesla Destination Charger
Gulfport, Mississippi
Tesla Destination
1 DCFC
Electric Vehicle Charging Station
Gulfport, Mississippi
Other
1 DCFC
Electric Vehicle Charging Station
Gulfport, Mississippi
Other
1 DCFC
ChargePoint Charging Station
Amory, Mississippi
ChargePoint
1 DCFC
Other: 3
Tesla Destination: 2
ChargePoint: 1
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $32 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
91.3
1
$31.94
$14.60
Efficient EV
76.1
0
$26.62
$12.17
EV Truck/SUV
121.7
1
$42.59
$19.47
Gas CO2
106 kg
EV CO2
36 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Gulfport, MS
Night
in Gulfport on Thursday
Local time
9:22 PM
CDT
Current temp
60°F
Unavailable
Live forecast
Destination
Greenwood, MS
Night
in Greenwood on Thursday
Local time
9:22 PM
CDT
Current temp
77°F
Unavailable
Live forecast
79°F
Meridian, MS
152 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
17 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 20m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Gulfport, MS to Greenwood, MS covers 304.2 miles and takes about 6h 20m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 45, Lance Corporal Roy M Wheat Memorial Highway, 25th Avenue. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 152.1 miles from Gulfport, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $45.94 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 17 significant decision points across 304.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 65.3 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 154.5 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 163.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Between Gulfport, MS and Greenwood, MS, road signs point toward Laurel, Tuscaloosa and Aberdeen.
