The drive from Gulfport, MS to Ruleville, MS covers 273.4 miles and takes about 5h 44m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on US 49, US 49W, 25th Avenue for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 100.8 miles on US 49.
At current regular gas prices, budget about $41.29 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
136.7 miles from Gulfport, MS
A natural place for your longest stop of the day
, about 2h 50m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 44m. Total distance: 273.4 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 44m drive, comfortable solo distance.
Drive Character
This is a 5h 44m highway drive covering 273.4 miles, with most of the trip on US 49 and US 49W. The longest continuous stretch is about 100.8 miles on US 49.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 20 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 49 is the longest continuous segment at about 100.8 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on US 49 and US 49W. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 153.7 miles in near US 49.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 12 significant decision points across 273.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 153.7 miles (US 49): Highway fork - watch signs carefully; at 154.4 miles (US 49): Highway fork - watch signs carefully; at 157.1 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 12 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
5
153.7 mi into trip|~3h 11m in|US 49
Keep slight left at fork onto US 49 toward Jackson
Highway fork - watch signs carefully
Toward Jackson
4
154.4 mi into trip|~3h 13m in|US 49
Keep slight left at fork onto US 49
Highway fork - watch signs carefully
6
157.1 mi into trip|~3h 16m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward I 20 West, US 49 North: Vicksburg, Yazoo City
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 West, US 49 North: Vicksburg, Yazoo...
5
159.8 mi into trip|~3h 19m in|US 49
Take the exit onto US 49 toward I 220 North, I 49 North: North Jackson, Yazoo City
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward I 220 North, I 49 North: North Jackson,...
5
204.8 mi into trip|~4h 15m in|US 49W
Take the exit onto US 49W toward US 49W North, MS 3 South: Indianola, Vicksburg
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward US 49W North, MS 3 South: Indianola, Vic...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Gulfport, MS and Ruleville, MS, road signs point toward Jackson, Yazoo City and Vicksburg.
Jackson
153.7 mi in|~3h 11m|via US 49
Yazoo City
157.1 mi in|~3h 16m|via I 20; US 49
Vicksburg
204.8 mi in|~4h 15m|via US 49W
Main Roads
Road
Distance
Duration
US 49
100.8 mi
2h 6m
US 49W
68.3 mi
1h 29m
25th Avenue
60.1 mi
1h 14m
Medgar Evers Boulevard
39.5 mi
48m
I 20
4.3 mi
5m
East Floyce Street
0.3 mi
<1m
West Floyce Street
<0.1 mi
<1m
Longest stretch:
US 49
— 100.8 mi, about 2h 6m
Turn-by-Turn Driving Directions
Step-by-step road directions between Gulfport, MS and Ruleville, MS.
1
Start on US 49
60 mi·1 hr 14 min·25th Avenue
Use the straight lane.
2
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
3
Turn straight onto US 49
10 mi·16 min·US 49
Use the straight lane.
4
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
5
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
6
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
7
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
8
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
9
Take the exit onto US 49
0.2 mi·21 sec·US 49
10
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
11
Keep slight left at fork onto US 49
1.0 mi·1 min·US 49
12
Merge onto I 20; I 55; US 49
1.6 mi·2 min·I 20; I 55; US 49
13
Keep slight right at fork onto I 20; US 49
2.7 mi·3 min·I 20; US 49
Toward I 20 West, US 49 North: Vicksburg, Yazoo City
14
Take the exit onto US 49
5.2 mi·6 min·US 49
Toward I 220 North, I 49 North: North Jackson, Yazoo City
15
Take the exit onto US 49
0.3 mi·33 sec·US 49
Toward US 49 North: Yazoo City
16
Merge onto US 49
39 mi·48 min·Medgar Evers Boulevard
17
Take the exit onto US 49W
68 mi·1 hr 29 min·US 49W
Toward US 49W North, MS 3 South: Indianola, Vicksburg
18
Turn left onto East Floyce Street
0.3 mi·37 sec·East Floyce Street
19
Continue on West Floyce Street
123 ft·6 sec·West Floyce Street
20
Arrive at destination
West Floyce Street
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 136.7 miles from Gulfport, MS, or about 2h 50m into the drive.
The longest continuous stretch on this route runs about 100.8 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 60 miles or 1h 14m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 136.7 miles or 2h 50m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 40m
Traffic, exits, and arrival timing usually matter more near Ruleville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Gulfport, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Gulfport, MS
This is one driving day of about 273.4 miles and 5h 44m.
Your first comfortable stop window is around 60 miles from Gulfport, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 100.8 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 136.7 mi from Gulfport, MS
· 2h 50m into the drive
The midpoint is around 136.7 miles from Gulfport, MS, which is a good place for a longer meal and fuel stop.
Arriving in Ruleville, MS
The final approach into Ruleville, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Ruleville, MS.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
4 mi from route
~9 min detour
Free
near mile 160.3
Emmett Till and Mamie Till-Mobley National Monument
National Monument
In 1955, 14-year-old Emmett Till traveled to Money, Mississippi, to visit relatives. He was kidnapped, tortured, and murdered after reportedly whistling at a white woman. His mother, Mamie Till-Mobley...
20 mi from route
~50 min detour
Free
near mile 273.4
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$41.29 one way
$82.58 round trip
$3.84/gal25.4 MPG avg96 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$45.33
$90.65
premium
$4.56
$49.07
$98.14
diesel
$5.61
$60.36
$120.73
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$41
Meals
$25–$50
Total
$66–$91
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 95.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $29 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
82
1
$28.71
$13.12
Efficient EV
68.4
0
$23.92
$10.94
EV Truck/SUV
109.4
1
$38.28
$17.50
Gas CO2
96 kg
EV CO2
32 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Gulfport, MS
Afternoon
in Gulfport on Friday
Local time
2:51 PM
CDT
Current temp
60°F
Unavailable
Live forecast
Destination
Ruleville, MS
Afternoon
in Ruleville on Friday
Local time
2:51 PM
CDT
Current temp
56°F
Unavailable
Live forecast
55°F
Florence, MS
137 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
4 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 44m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Gulfport, MS to Ruleville, MS covers 273.4 miles and takes about 5h 44m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 49, US 49W, 25th Avenue. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 136.7 miles from Gulfport, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $41.29 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 12 significant decision points across 273.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 153.7 miles (US 49): Highway fork - watch signs carefully; at 154.4 miles (US 49): Highway fork - watch signs carefully; at 157.1 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Between Gulfport, MS and Ruleville, MS, road signs point toward Jackson, Yazoo City and Vicksburg.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.
