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Trip from Jeffersonville, IN to Lowell, IN

Drive Time

4h 38m

Distance

246.4 mi

397 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$37

one way

EV Charging

None

0 DC fast

Best Time to Leave

Save up to 40 min
4 AM
4h 25m ★
6 AM
4h 38m
8 AM
5h 5m
10 AM
4h 47m
12 PM
4h 45m
3 PM
4h 49m
5 PM
5h 4m
8 PM
4h 30m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Best Time Drive vs Fly
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Downtown Jeffersonville, IN, IN

Jeffersonville, IN

Anthony Stewart

Trip Overview

The drive from Jeffersonville, IN to Lowell, IN covers 246.4 miles and takes about 4h 38m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.

The route leans on I 65, East 181st Avenue, East Commercial Avenue for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 238.5 miles on I 65. At current regular gas prices, budget about $37.43 one way before food or hotel costs.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

123.2 miles from Jeffersonville, IN

A natural place for your longest stop of the day , about 2h 18m into the drive .

Drive Character

This is a 4h 38m highway drive covering 246.4 miles, with most of the trip on I 65 and East 181st Avenue. The longest continuous stretch is about 238.5 miles on I 65.

Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 13 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 65 is the longest continuous segment at about 238.5 miles.

How Hard Is This Drive?

This is a straightforward highway drive that stays mostly on I 65 and East 181st Avenue. You will hit about 9 points where you need to pay attention to lane position or signs. The trickiest moment comes around 0.9 miles in near I 65.

Route Complexity 6/10

Moderate - straightforward overall, but long enough or busy enough to require pacing

This drive requires moderate attention. Across 246.4 miles you will encounter 9 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.

Where does it get tricky?

The main spots that need attention: at 0.9 miles (I 65): Merge point - match speed before joining. Lane positioning matters here; at 111.9 miles (I 65): Highway fork - watch signs carefully. Lane positioning matters here; at 141.7 miles (US 52): Exit ramp - move to the correct lane early.

Critical Maneuvers

5 of 9 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

5
0.9 mi into trip | ~2m in | I 65

Merge onto I 65

Merge point - match speed before joining. Lane positioning matters here

Use the straight / slight right lanes.
6
111.9 mi into trip | ~2h 5m in | I 65

Keep slight right at fork onto I 65

Highway fork - watch signs carefully. Lane positioning matters here

Use the slight right lane.
5
141.7 mi into trip | ~2h 41m in | US 52

Take the exit onto US 52 toward US 52 West

Exit ramp - move to the correct lane early

Exit 141 Toward US 52 West
5
141.9 mi into trip | ~2h 41m in

Keep slight left at fork

Highway fork - watch signs carefully

8
239.8 mi into trip | ~4h 27m in

Take the exit toward SR 2: Lowell, Hebron

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Exit 240 Toward SR 2: Lowell, Hebron

Main Roads

Road Distance Duration
I 65 238.5 mi 4h 24m
East 181st Avenue 4.8 mi 6m
East Commercial Avenue 1.5 mi 3m
East Court Avenue 0.4 mi 1m
6th Street 0.3 mi <1m
US 52 0.2 mi <1m
Watt Street <0.1 mi <1m
Longest stretch: I 65 — 238.5 mi, about 4h 24m

Turn-by-Turn Driving Directions

Step-by-step road directions between Jeffersonville, IN and Lowell, IN.

1

Start on Watt Street

257 ft · 13 sec · Watt Street
2

Turn right onto East Court Avenue

0.4 mi · 1 min · East Court Avenue
3

Turn slight right onto 6th Street

0.3 mi · 45 sec · 6th Street
4

Take the ramp

0.2 mi · 28 sec
5

Merge onto I 65

111 mi · 2 hr 2 min · I 65
Use the straight / slight right lanes.
6

Keep slight right at fork onto I 65

30 mi · 35 min · I 65
Use the slight right lane.
7

Take the exit onto US 52

0.2 mi · 15 sec · US 52
Exit 141 Toward US 52 West
8

Keep slight left at fork

0.1 mi · 9 sec
9

Merge onto I 65

98 mi · 1 hr 45 min · I 65
10

Take the exit

0.3 mi · 41 sec
Exit 240 Toward SR 2: Lowell, Hebron Use the slight right lane.
11

Turn left onto SR 2

4.8 mi · 6 min · East 181st Avenue
12

Continue on SR 2

1.5 mi · 3 min · East Commercial Avenue
13

Arrive at destination

SR 2

Trip Plan

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 123.2 miles from Jeffersonville, IN, or about 2h 18m into the drive.
The longest continuous stretch on this route runs about 238.5 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 80 miles or 1h 30m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 123.2 miles or 2h 18m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 3h 46m

Traffic, exits, and arrival timing usually matter more near Lowell, IN than in the middle of the route.

Before You Leave

+

Open the route before leaving Jeffersonville, IN so your first major turns are already loaded.

+

Leave with enough water and a charging cable within reach, not packed away.

+

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Jeffersonville, IN

This is one driving day of about 246.4 miles and 4h 38m.

Your first comfortable stop window is around 80 miles from Jeffersonville, IN.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 65 for about 238.5 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 123.2 mi from Jeffersonville, IN · 2h 18m into the drive

Downtown Cincinnati, OH, OH

Mid-route town

Meal stop

Cincinnati, OH

123 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Cincinnati, OH

Fuel and coffee

A short stop after about 80 miles helps settle the day before fatigue starts building.

Cincinnati, OH

Meal break

The midpoint is around 123.2 miles from Jeffersonville, IN, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before I 65 if your tank is already low. That segment runs about 238.5 miles.

Arriving in Lowell, IN

The final approach into Lowell, IN usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Lowell, IN.

After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

National Parks Near This Route

Worth a detour if your schedule allows.

Indiana Dunes National Park

Indiana Dunes National Park

National Park

Lake Michigan's might has influenced Indiana Dunes for millennia. Wind and waves have shaped the land, leaving a rich mosaic of habitats along these 15 miles of Indiana coast. Over 50 miles of trails...

28 mi from route ~70 min detour $20 near mile 237.9
Park Closure: Partial Closures to Marquette Greenway Trail and Glenwood Dunes Trail
Park Closure: Mount Baldy Closure
View on nps.gov

Park data from the National Park Service API. Alerts update every 2 hours.

Fuel & Cost

Regular Gas

$37.43 one way

$74.85 round trip

$3.86/gal 25.4 MPG avg 86 kg CO2
Fuel Type $/gal One Way Round Trip
midgrade $4.25 $41.26 $82.51
premium $4.80 $46.52 $93.03
diesel $5.64 $54.74 $109.48

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$37

Meals

$25–$50

Total

$62–$87

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 86.2 kg one way. Prices: EIA weekly data, 2026-04-06.

Driving Electric?

About $26 in charging · 0 stops · 66% less CO2

Vehicle Type kWh Stops DC Fast Home Charge
Average EV 73.9 0 $25.87 $11.83
Efficient EV 61.6 0 $21.56 $9.86
EV Truck/SUV 98.6 1 $34.50 $15.77

Gas CO2

86 kg

EV CO2

29 kg (66% less)

Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 1 hour ago

Origin

Jeffersonville, IN

Morning in Jeffersonville on Monday

Local time

10:11 AM

EDT

Current temp

80°F

Chance Showers And Thunderstorms

SW 8 to 14 mph 42% chance Live forecast

Flood Warning

Flood Warning issued April 12 at 10:34PM EDT until April 16 at 2:00AM EDT by NWS Northern Indiana

Flood Warning

Flood Warning issued April 12 at 10:27PM EDT until April 13 at 10:00PM EDT by NWS Indianapolis IN

Destination

Lowell, IN

Morning in Lowell on Monday

Local time

9:11 AM

CDT

Current temp

52°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

1 hour earlier

The destination clock does not match departure time, so double-check hotel check-in windows and late arrival plans.

Temperature spread

28 degrees cooler at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

4h 38m on the road

An early start around 7-8 AM gets you there with plenty of daylight left.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Jeffersonville, IN to Lowell, IN covers 246.4 miles and takes about 4h 38m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 65, East 181st Avenue, East Commercial Avenue. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 123.2 miles from Jeffersonville, IN. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $37.43 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This drive requires moderate attention. Across 246.4 miles you will encounter 9 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: at 0.9 miles (I 65): Merge point - match speed before joining. Lane positioning matters here; at 111.9 miles (I 65): Highway fork - watch signs carefully. Lane positioning matters here; at 141.7 miles (US 52): Exit ramp - move to the correct lane early.
The route from Jeffersonville, IN to Lowell, IN does not surface many named destination signs beyond the main corridor.

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