The drive from Knoxville, TN to Tiptonville, TN covers 378.2 miles and takes about 7h 7m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 40, US 412, State Route 78 for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 304.2 miles on I 40.
At current regular gas prices, budget about $57.44 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
189.1 miles from Knoxville, TN
A natural place for your longest stop of the day
, about 3h 28m into the drive
.