Trip from Manteo, NC to Winston-Salem, NC

Drive Time

4h 38m

Distance

292.4 mi

471 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$47

one way

Best Time to Leave

Save up to 40 min

4 AM

4h 25m ★

6 AM

4h 38m

8 AM

5h 5m

10 AM

4h 48m

12 PM

4h 45m

3 PM

4h 49m

5 PM

5h 4m

8 PM

4h 30m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Best Time Drive vs Fly

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Trip Overview

The drive from Manteo, NC to Winston-Salem, NC covers 292.4 miles and takes about 4h 38m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.

The route leans on Highway 64, Rolesville Road, Marks Creek Road for much of the mileage, and the overall profile is turn-heavy local drive. At current regular gas prices, budget about $46.80 one way before food or hotel costs.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

146.2 miles from Manteo, NC

A natural place for your longest stop of the day , about 2h 19m into the drive .

Drive Character

Expect a 4h 38m drive with frequent turns across 292.4 miles of local and secondary roads.

This route has more turning and local-road decision points than a simple highway run.

There are about 26 navigation steps in the underlying route data, so the final approach matters more than the middle miles.

Highway 64 is one of the defining roads on this drive.

How Hard Is This Drive?

Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. There are only a few real navigation decisions along the way.

Route Complexity 3/10

Easy - simple navigation with a manageable amount of wheel time

This is a straightforward 4h 38m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.

Where does it get tricky?

This route does not have any notably tricky sections. Most of the drive from Manteo, NC to Winston-Salem, NC is straightforward, with well-signed roads and simple exits.

Main Roads

Road	Distance	Duration
Highway 64	Unavailable	Refreshing
Rolesville Road	Unavailable	Refreshing
Marks Creek Road	Unavailable	Refreshing
Horton Road	Unavailable	Refreshing
Buffaloe Road	Unavailable	Refreshing
Northern Wake Expressway	Unavailable	Refreshing
US 70 West	Unavailable	Refreshing
Glenwood Avenue	Unavailable	Refreshing

Per-road distance and duration are being refreshed from OSRM for this route.

Longest stretch: Highway 64 — detailed segment metrics are refreshing.

Turn-by-Turn Driving Directions

Step-by-step road directions between Manteo, NC and Winston-Salem, NC.

Start on N US Highway 64

1.5 mi · 3 min · N US Highway 64

Take the ramp slight right

180 ft · 5 sec

Merge slight left

18 mi · 24 min

Keep slight left

67 mi · 1 hr 27 min

Turn left

1.8 mi · 2 min

Continue straight

57 mi · 1 hr 1 min

Continue straight

28 mi · 29 min

Take the exit slight right toward Rolesville Road

0.2 mi · 29 sec · Rolesville Road

Keep slight right to continue on Rolesville Road

308 ft · 8 sec · Rolesville Road

Turn right onto Rolesville Road

2.4 mi · 4 min · Rolesville Road

Turn sharp left onto Marks Creek Road

0.4 mi · 39 sec · Marks Creek Road

Turn right onto Horton Road

0.4 mi · 44 sec · Horton Road

Turn right onto Buffaloe Road

3.8 mi · 6 min · Buffaloe Road

Take the ramp right

0.4 mi · 24 sec

Merge slight left onto Northern Wake Expressway

15 mi · 16 min · Northern Wake Expressway

Take the exit slight right toward US 70 West: Durham

0.6 mi · 1 min · US 70 West: Durham

Merge slight left onto Glenwood Avenue

1.9 mi · 2 min · Glenwood Avenue

Continue on New Raleigh Highway

2.5 mi · 3 min · New Raleigh Highway

Continue on South Miami Boulevard

9.3 mi · 12 min · South Miami Boulevard

Keep slight left

42 mi · 48 min

Keep slight right

7.7 mi · 9 min

Keep slight right

13 mi · 15 min

Keep slight right to continue on Salem Parkway

13 mi · 16 min · Salem Parkway

Take the exit slight right toward Main Street

0.2 mi · 29 sec · Main Street

Turn slight right onto South Main Street

0.4 mi · 44 sec · South Main Street

Arrive at your destination

Trip Plan

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.

Plan roughly 1 meaningful break for fuel, food, and rest.

The halfway point lands around 146.2 miles from Manteo, NC, or about 2h 19m into the drive.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 80 miles or 1h 16m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 146.2 miles or 2h 19m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 3h 48m

Traffic, exits, and arrival timing usually matter more near Winston-Salem, NC than in the middle of the route.

Before You Leave

Open the route before leaving Manteo, NC so your first major turns are already loaded.

Leave with enough water and a charging cable within reach, not packed away.

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Manteo, NC

This is one driving day of about 292.4 miles and 4h 38m.

Your first comfortable stop window is around 80 miles from Manteo, NC.

This route can stay practical as a one-day drive if traffic stays reasonable.

Plan about 1 real break rather than only quick fuel stops.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 146.2 mi from Manteo, NC · 2h 19m into the drive

Mid-route town

Meal stop

Raleigh, NC

146 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Popular next leg

Raleigh, NC to Winston-Salem, NC

107.4 mi · 1h 39m

Pacing Suggestions

Greenville, NC

Fuel and coffee

A short stop after about 80 miles helps settle the day before fatigue starts building.

Raleigh, NC

Meal break

The midpoint is around 146.2 miles from Manteo, NC, which is a good place for a longer meal and fuel stop.

Arriving in Winston-Salem, NC

The final approach into Winston-Salem, NC usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Winston-Salem, NC.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$46.80 one way

$93.59 round trip

$4.07/gal 25.4 MPG avg 102 kg CO₂

Fuel Type	$/gal	One Way	Round Trip
midgrade	$4.43	$50.99	$101.97
premium	$4.78	$55.00	$110.01
diesel	$5.64	$64.96	$129.92

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$47

Meals

$25–$50

Total

$72–$97

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 102.3 kg one way. Prices: EIA weekly data, 2026-04-06.

Driving Electric?

About $31 in charging · 1 stop · 67% less CO₂

Vehicle Type	kWh	Stops	DC Fast	Home Charge
Average EV	87.7	1	$30.70	$14.04
Efficient EV	73.1	0	$25.58	$11.70
EV Truck/SUV	117	1	$40.94	$18.71

Gas CO2

102 kg

EV CO2

34 kg (67% less)

Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 3 years ago

Origin

Manteo, NC

Afternoon in Manteo on Sunday

Local time

4:16 PM

EDT

Current temp

74°F

Unavailable

Live forecast

Destination

Winston-Salem, NC

Afternoon in Winston-Salem on Sunday

Local time

4:16 PM

EDT

Current temp

90°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

16 degrees warmer at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

4h 38m on the road

An early start around 7-8 AM gets you there with plenty of daylight left.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Manteo, NC to Winston-Salem, NC covers 292.4 miles and takes about 4h 38m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.

The main roads are Highway 64, Rolesville Road, Marks Creek Road. Expect a mix of highway and local road driving.

This is a comfortable same-day trip.

The midpoint is about 146.2 miles from Manteo, NC. Look for rest areas, gas stations, or food options near the halfway mark.

At current regular gas prices, expect to spend about $46.80 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.

An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.

Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

This is a straightforward 4h 38m drive. You will face about 0 decision points, but nothing that requires special attention if you follow navigation.

This route does not have any notably tricky sections. Most of the drive from Manteo, NC to Winston-Salem, NC is straightforward, with well-signed roads and simple exits.

The route from Manteo, NC to Winston-Salem, NC does not surface many named destination signs beyond the main corridor.

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