Origin
Maryville, MO
Late night in Maryville on Wednesday
Local time
5:34 AM
CDT
Current temp
44°F
Unavailable
Live forecast
Trip from Maryville, MO to Saint Charles, MO
Data updated 0 seconds ago
Drive Time
6h 11m
Distance
325.7 mi
524 km
Drive Score
10/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$51
one way
EV Charging
Loading...
station data
Best Time to Leave
4 AM
5h 59m
★
6 AM
6h 12m
8 AM
6h 37m
10 AM
6h 21m
12 PM
6h 18m
3 PM
6h 22m
5 PM
6h 36m
8 PM
6h 4m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Saint Charles, MO
Wikimedia Commons
Trip Overview
The drive from Maryville, MO to Saint Charles, MO covers 325.7 miles and takes about 6h 11m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, I 29 for much of the mileage, and the overall profile is mixed drive. The longest uninterrupted segment is about 153.3 miles on Dwight D. Eisenhower Highway. At current regular gas prices, budget about $50.92 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
162.8 miles from Maryville, MO
A natural place for your longest stop of the day , about 3h 1m into the drive .
Loading map...
Drive Character
The drive from Maryville, MO to Saint Charles, MO covers 325.7 miles and takes about 6h 11m, using a mix of highways and local roads.
Expect a mix of faster highway mileage and slower local approaches near the beginning or end.
There are about 27 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Dwight D. Eisenhower Highway is the longest continuous segment at about 153.3 miles.
How Hard Is This Drive?
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 74.8 miles in near I 435.
Route Complexity
8/10
Demanding - plan breaks and stay ahead of the key maneuvers
This is a demanding drive. With 12 significant decision points across 325.7 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 74.8 miles (I 435): Highway fork - watch signs carefully. Lane positioning matters here; at 102.7 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 103 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Critical Maneuvers
5 of 12 key pointsThese are the spots where you need to pay the most attention. Preview them before you drive.
8
74.8 mi into trip
|
~1h 24m in
|
I 435
Keep slight right at fork onto I 435 toward I 435 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Exit 14
Toward I 435 East: Saint Louis
7
102.7 mi into trip
|
~1h 55m in
|
US 24
Keep slight right at fork onto US 24 toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 63
Toward I 70, US 24 West, US 40: Saint Louis, Ka...
7
103 mi into trip
|
~1h 55m in
Keep slight left at fork toward I 70 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Toward I 70 East: Saint Louis
8
323.4 mi into trip
|
~6h 5m in
Take the exit toward I 70 Business, MO 94: First Capitol Drive, Lewis and Clark Trail
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 228
Toward I 70 Business, MO 94: First Capitol Driv...
9
323.5 mi into trip
|
~6h 6m in
Keep slight left at fork toward I 70 Business, MO 94 East: First Capitol Drive, Lindenwood University, SSM Health Saint Joseph Hospital
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 70 Business, MO 94 East: First Capitol...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Maryville, MO and Saint Charles, MO, road signs point toward Kansas City and Sports Complex.
Kansas City
102.7 mi in
|
~1h 55m
|
via US 24
Sports Complex
102.7 mi in
|
~1h 55m
|
via US 24
Main Roads
| Road | Distance | Duration |
|---|---|---|
| Dwight D. Eisenhower Highway | 153.3 mi | 2h 56m |
| U.S. Submarine Veterans' Memorial Highway | 54.4 mi | 58m |
| I 29 | 39.4 mi | 42m |
| US 71 (MO) | 30 mi | 34m |
| I 435 | 28 mi | 30m |
| Truman/Eisenhower Presidential Highway | 5.6 mi | 6m |
| US 59 | 3.2 mi | 3m |
| South Main Street | 2.2 mi | 3m |
Longest stretch:
Dwight D. Eisenhower Highway
— 153.3 mi, about 2h 56m
Turn-by-Turn Driving Directions
Step-by-step road directions between Maryville, MO and Saint Charles, MO.
1
Start on MO 46
134 ft
·
10 sec
·
East 1st Street
2
Turn left onto US 71 Business
2.2 mi
·
3 min
·
South Main Street
3
Continue on US 71
30 mi
·
34 min
·
US 71 (MO)
4
Take the exit onto US 59; US 71
3.2 mi
·
3 min
·
US 59; US 71
Toward I 29 South, US 71 South, US 59 South: Kansas City
5
Continue on I 29; US 71
37 mi
·
40 min
·
I 29; US 71
6
Merge onto I 29; I 435; US 71
2.2 mi
·
2 min
·
I 29; I 435; US 71
Use the straight / slight right lanes.
7
Keep slight right at fork onto I 435
28 mi
·
30 min
·
I 435
Exit 14
Toward I 435 East: Saint Louis
Use the straight / slight right lanes.
8
Keep slight right at fork onto US 24
0.3 mi
·
23 sec
·
US 24
Exit 63
Toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
9
Keep slight left at fork
1.2 mi
·
1 min
Toward I 70 East: Saint Louis
Use the straight / slight right lanes.
10
Keep slight left at fork
469 ft
·
11 sec
Toward I 70 East: Saint Louis
Use the slight left / straight lanes.
11
Merge onto I 70
0.4 mi
·
29 sec
·
George Brett Super Highway
12
Continue on I 70
2.9 mi
·
3 min
·
Truman/Eisenhower Presidential Highway
13
Continue on I 70
1.8 mi
·
2 min
·
Clifton J. Scott Memorial Highway
Use the straight / slight right lanes.
14
Continue on I 70
2.6 mi
·
3 min
·
Truman/Eisenhower Presidential Highway
15
Continue on I 70
53 mi
·
56 min
·
Dwight D. Eisenhower Highway
16
Continue on I 70; US 40
32 mi
·
34 min
·
U.S. Submarine Veterans' Memorial Highway
17
Keep slight left at fork onto I 70
22 mi
·
24 min
·
U.S. Submarine Veterans' Memorial Highway
18
Continue on I 70; US 40
1.8 mi
·
2 min
·
Dwight D. Eisenhower Highway
19
Continue on I 70; US 40
1.6 mi
·
1 min
·
Highway Patrol Sgt. Benjamin Booth Memorial Highway
20
Continue on I 70; US 40
1.9 mi
·
2 min
·
Sheriff Roger I. Wilson Memorial Highway
21
Continue on I 70; US 40
99 mi
·
1 hr 57 min
·
Dwight D. Eisenhower Highway
Use the straight / slight right lanes.
22
Take the exit
0.1 mi
·
14 sec
Exit 228
Toward I 70 Business, MO 94: First Capitol Drive, Lewis and Clark Trail
Use the slight right lane.
23
Keep slight left at fork
0.1 mi
·
14 sec
Toward I 70 Business, MO 94 East: First Capitol Drive, Lindenwood University, SSM Health Saint Joseph Hospital
Use the slight left / slight right lanes.
24
Turn straight onto I 70 Business; MO 94
0.9 mi
·
2 min
·
First Capitol Drive
25
Turn slight right onto I 70 Business; MO 94
0.9 mi
·
2 min
·
I 70 Business; MO 94
Toward MO 94
26
Turn left onto South Second Street
0.3 mi
·
56 sec
·
South Second Street
27
Arrive at destination
North Second Street
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 162.8 miles from Maryville, MO, or about 3h 1m into the drive.
The longest continuous stretch on this route runs about 153.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 30m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 162.8 miles or 3h 1m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 59m
Traffic, exits, and arrival timing usually matter more near Saint Charles, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Maryville, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Maryville, MO
This is one driving day of about 325.7 miles and 6h 11m.
Your first comfortable stop window is around 80 miles from Maryville, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 153.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 162.8 mi from Maryville, MO · 3h 1m into the drive
Mid-route town
Meal stop
163 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 80 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 162.8 miles from Maryville, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before Dwight D. Eisenhower Highway if your tank is already low. That segment runs about 153.3 miles.
Arriving in Saint Charles, MO
The final approach into Saint Charles, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Saint Charles, MO.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$50.92 one way
$101.84 round trip
$3.97/gal
25.4 MPG avg
114 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.36 | $55.91 | $111.82 |
| premium | $4.89 | $62.68 | $125.36 |
| diesel | $5.61 | $71.91 | $143.82 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$51
Meals
$25–$50
Total
$76–$101
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 114 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $34 in charging · 1 stop · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 97.7 | 1 | $34.20 | $15.63 |
| Efficient EV | 81.4 | 0 | $28.50 | $13.03 |
| EV Truck/SUV | 130.3 | 1 | $45.60 | $20.84 |
Gas CO2
114 kg
EV CO2
38 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Saint Charles, MO
Late night in Saint Charles on Wednesday
Local time
5:34 AM
CDT
Current temp
55°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
11 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 11m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Maryville, MO to Saint Charles, MO covers 325.7 miles and takes about 6h 11m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, I 29. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 162.8 miles from Maryville, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $50.92 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 12 significant decision points across 325.7 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 74.8 miles (I 435): Highway fork - watch signs carefully. Lane positioning matters here; at 102.7 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 103 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Between Maryville, MO and Saint Charles, MO, road signs point toward Kansas City and Sports Complex.
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