The drive from Maysville, KY to Henderson, KY covers 264.1 miles and takes about 5h 11m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 64, US 68, I 69 for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 173.3 miles on I 64.
At current regular gas prices, budget about $41.29 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
132 miles from Maysville, KY
A natural place for your longest stop of the day
, about 2h 38m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 11m. Total distance: 264.1 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 11m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (92%). Some complex stretches to watch for.
Drive Character
This is a 5h 11m highway drive covering 264.1 miles, with most of the trip on I 64 and US 68. The longest continuous stretch is about 173.3 miles on I 64.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 28 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 64 is the longest continuous segment at about 173.3 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 64 and US 68. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.8 miles in near US 62; KY 10 / Coughlin Boulevard.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 17 significant decision points across 264.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.8 miles (US 62; KY 10 / Coughlin Boulevard): Sharp turn - reduce speed on approach. Lane positioning matters here; at 65.5 miles (I 64): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 234.7 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 17 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
7
0.8 mi into trip|~1m in|US 62; KY 10 / Coughlin Boulevard
Turn sharp left onto US 62; KY 10 / Coughlin Boulevard
Sharp turn - reduce speed on approach. Lane positioning matters here
Use the left lane.
8
65.5 mi into trip|~1h 23m in|I 64
Keep slight left at fork onto I 64 toward I 64 West: Frankfort, Louisville
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 64 West: Frankfort, Louisville
8
234.7 mi into trip|~4h 31m in
Take the exit toward I 69 South, SR 57 South: Evansville, Henderson, Kentucky
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 29A
Toward I 69 South, SR 57 South: Evansville, Hen...
8
255.7 mi into trip|~4h 56m in
Keep slight right at fork toward US 41 South: Henderson, Kentucky
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward US 41 South: Henderson, Kentucky
9
255.8 mi into trip|~4h 57m in
Keep slight right at fork toward US 41 South: Henderson, Kentucky
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward US 41 South: Henderson, Kentucky
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Maysville, KY and Henderson, KY, road signs point toward Louisville and Kentucky.
Louisville
60.9 mi in|~1h 17m
Kentucky
234.7 mi in|~4h 31m
Main Roads
Road
Distance
Duration
I 64
173.3 mi
3h 12m
US 68
22.8 mi
27m
I 69
20.1 mi
23m
US 68 Business
17.2 mi
23m
Lexington Road
6.8 mi
7m
US 41
6.1 mi
8m
Paris Pike
5.9 mi
6m
Coughlin Boulevard
2.9 mi
4m
Longest stretch:
I 64
— 173.3 mi, about 3h 12m
Turn-by-Turn Driving Directions
Step-by-step road directions between Maysville, KY and Henderson, KY.
1
Start on KY 10
0.8 mi·1 min·Forest Avenue
2
Turn sharp left onto US 62; KY 10
2.9 mi·4 min·Coughlin Boulevard
Use the left lane.
3
Continue on US 62; US 68
1.7 mi·2 min·US 62; US 68
Use the straight / left / right lanes.
4
Continue on US 68 Business
17 mi·23 min·US 68 Business
5
Continue on US 68; KY 165
23 mi·27 min·US 68; KY 165
6
Continue on US 460; US 68 Business
0.8 mi·1 min·East Main Street
7
Turn right onto US 460; US 68 Business
0.7 mi·1 min·Bank Row Street
8
At end of road, turn right onto US 68 Business
1.1 mi·1 min·Main Street
9
Continue on US 27; US 68
6.8 mi·7 min·Lexington Road
10
Continue on US 27; US 68
5.9 mi·6 min·Paris Pike
11
Continue on US 27; US 68
0.2 mi·18 sec·North Broadway
12
Take the exit
0.4 mi·52 sec
Toward I 75 North, I 64 West: Cincinnati, Louisville
13
Merge onto I 64; I 75
4.1 mi·4 min·I 64; I 75
14
Keep slight left at fork onto I 64
74 mi·1 hr 23 min·I 64
Toward I 64 West: Frankfort, LouisvilleUse the straight / slight right lanes.
15
Keep slight right at fork onto I 64; US 150
5.3 mi·7 min·I 64; US 150
Use the straight / slight left lanes.
16
Continue on I 64; SR 62
90 mi·1 hr 37 min·I 64; SR 62
17
Take the exit
0.3 mi·49 sec
Exit 29AToward I 69 South, SR 57 South: Evansville, Henderson, KentuckyUse the slight right lane.
18
Merge onto I 69; SR 57
20 mi·23 min·I 69; SR 57
19
Take the exit
0.2 mi·16 sec
Toward US 41: Vincennes, Henderson, Kentucky
20
Keep slight left at fork
0.5 mi·46 sec
Toward US 41 South: Henderson, Kentucky
21
Keep slight right at fork
0.1 mi·26 sec
Toward US 41 South: Henderson, KentuckyUse the slight right lane.
22
Keep slight right at fork
0.3 mi·46 sec
Toward US 41 South: Henderson, KentuckyUse the slight right lane.
23
Merge onto US 41
6.1 mi·8 min·US 41
24
Take the exit
0.2 mi·35 sec
Exit 15BToward US 60 West, US 41 Alternate: Henderson
25
Turn straight onto US 60; US 41 Alt
1.6 mi·3 min·US 60; US 41 Alt
26
Turn left onto Washington Street
213 ft·10 sec·Washington Street
27
Turn left
98 ft·7 sec
28
Arrive at destination
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 132 miles from Maysville, KY, or about 2h 38m into the drive.
The longest continuous stretch on this route runs about 173.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 58 miles or 1h 14m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 132 miles or 2h 38m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 11m
Traffic, exits, and arrival timing usually matter more near Henderson, KY than in the middle of the route.
Before You Leave
+
Open the route before leaving Maysville, KY so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Maysville, KY
This is one driving day of about 264.1 miles and 5h 11m.
Your first comfortable stop window is around 58 miles from Maysville, KY.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 64 for about 173.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 132 mi from Maysville, KY
· 2h 38m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Camp Nelson National Monument
National Monument
The US Army established Camp Nelson as a fortified supply depot in April 1863. Over the next 3 years, the site evolved into a massive recruitment and training center for United States Colored Troops a...
22 mi from route
~55 min detour
Free
near mile 64.1
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$41.29 one way
$82.58 round trip
$3.97/gal25.4 MPG avg92 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$45.33
$90.67
premium
$4.89
$50.82
$101.65
diesel
$5.61
$58.31
$116.62
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$41
Meals
$25–$50
Total
$66–$91
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 92.4 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $28 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
79.2
0
$27.73
$12.68
Efficient EV
66
0
$23.11
$10.56
EV Truck/SUV
105.6
1
$36.97
$16.90
Gas CO2
92 kg
EV CO2
31 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Maysville, KY
Night
in Maysville on Friday
Local time
10:43 PM
EDT
Current temp
51°F
Unavailable
Live forecast
Destination
Henderson, KY
Night
in Henderson on Friday
Local time
9:43 PM
CDT
Current temp
75°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
1 hour earlier
The destination clock does not match departure time, so double-check hotel check-in windows and late arrival plans.
Temperature spread
24 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 11m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Maysville, KY to Henderson, KY covers 264.1 miles and takes about 5h 11m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 64, US 68, I 69. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 132 miles from Maysville, KY. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $41.29 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 17 significant decision points across 264.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 0.8 miles (US 62; KY 10 / Coughlin Boulevard): Sharp turn - reduce speed on approach. Lane positioning matters here; at 65.5 miles (I 64): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 234.7 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Maysville, KY and Henderson, KY, road signs point toward Louisville and Kentucky.
Yes. Nearby national parks include Camp Nelson National Monument.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.
