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Sanford, ME
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Trip Overview
The drive from Medway, ME to Sanford, ME covers 222.9 miles and takes about 4h 10m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 95, I 295, Maine Turnpike for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 140.9 miles on I 95.
At current regular gas prices, budget about $35.88 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
111.5 miles from Medway, ME
A natural place for your longest stop of the day
, about 2h into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 10m. Total distance: 222.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 10m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (92%). Some complex stretches to watch for.
Drive Character
This is a 4h 10m highway drive covering 222.9 miles, with most of the trip on I 95 and I 295. The longest continuous stretch is about 140.9 miles on I 95.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 17 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 95 is the longest continuous segment at about 140.9 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 95 and I 295. You will hit about 9 points where you need to pay attention to lane position or signs. The trickiest moment comes around 0.3 miles in near ME 157 / Medway Road.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 222.9 miles you will encounter 9 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 0.3 miles (ME 157 / Medway Road): Navigation decision point; at 142 miles (I 295): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 192.6 miles (I 295): Highway fork - watch signs carefully.
Critical Maneuvers
5 of 9 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
4
0.3 mi into trip|~1m in|ME 157 / Medway Road
Turn right onto ME 157 / Medway Road
Navigation decision point
9
142 mi into trip|~2h 32m in|I 295
Keep slight right at fork onto I 295 toward I 295 South, ME 9, ME 126: Gardiner, Brunswick
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Exit 103
Toward I 295 South, ME 9, ME 126: Gardiner, Bru...
4
192.6 mi into trip|~3h 31m in|I 295
Keep slight left at fork onto I 295
Highway fork - watch signs carefully
5
206.8 mi into trip|~3h 47m in
Take the exit toward ME 111: Biddeford
Exit ramp - move to the correct lane early
Exit 32
Toward ME 111: Biddeford
4
207.5 mi into trip|~3h 49m in|ME 111 / Alfred Street
Turn right onto ME 111 / Alfred Street
Navigation decision point
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Medway, ME to Sanford, ME, road signs begin pointing toward Brunswick along the way.
Brunswick
142 mi in|~2h 32m|via I 295
Main Roads
Road
Distance
Duration
I 95
140.9 mi
2h 29m
I 295
53.2 mi
1h 2m
Maine Turnpike
11.6 mi
12m
Alfred Road
8.2 mi
9m
Sanford Road
2.4 mi
3m
Biddeford Road
1.8 mi
2m
Alfred Street
1.4 mi
1m
Cottage Street
1.2 mi
3m
Longest stretch:
I 95
— 140.9 mi, about 2h 29m
Turn-by-Turn Driving Directions
Step-by-step road directions between Medway, ME and Sanford, ME.
1
Start on Main Road
0.3 mi·1 min·Main Road
2
Turn right onto ME 157
0.6 mi·1 min·Medway Road
3
Take the ramp
0.2 mi·31 sec
4
Merge onto I 95
141 mi·2 hr 29 min·I 95
5
Keep slight right at fork onto I 295
51 mi·58 min·I 295
Exit 103Toward I 295 South, ME 9, ME 126: Gardiner, BrunswickUse the straight lane.
6
Keep slight left at fork onto I 295
2.6 mi·3 min·I 295
7
Merge onto I 95
12 mi·12 min·Maine Turnpike
8
Take the exit
0.7 mi·1 min
Exit 32Toward ME 111: Biddeford
9
Turn right onto ME 111
1.4 mi·1 min·Alfred Street
10
Continue on ME 111
8.2 mi·9 min·Alfred Road
11
Continue on ME 111
1.8 mi·2 min·Biddeford Road
12
Continue on US 202; ME 4A
2.4 mi·3 min·Sanford Road
Use the left / straight / right lanes.
13
Continue on US 202; ME 4A
1.2 mi·3 min·Cottage Street
14
Turn left onto River Street
0.2 mi·26 sec·River Street
15
Continue on Washington Street
0.1 mi·25 sec·Washington Street
16
Turn left
89 ft·6 sec
17
Arrive at destination
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 111.5 miles from Medway, ME, or about 2h into the drive.
The longest continuous stretch on this route runs about 140.9 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 49 miles or 53m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 111.5 miles or 2h in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 20m
Traffic, exits, and arrival timing usually matter more near Sanford, ME than in the middle of the route.
Before You Leave
+
Open the route before leaving Medway, ME so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Medway, ME
This is one driving day of about 222.9 miles and 4h 10m.
Your first comfortable stop window is around 49 miles from Medway, ME.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 95 for about 140.9 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 111.5 mi from Medway, ME
· 2h into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Frances Perkins National Monument
National Monument
Known as the first woman to hold a presidential cabinet position and the “Woman behind the New Deal,” Frances Perkins championed many labor rights that Americans enjoy today, including safety standard...
17 mi from route
~42 min detour
Free
near mile 153.7
Spread across a wild landscape offering spectacular views of Katahdin, Katahdin Woods and Waters invites discovery of its rivers, streams, woods, flora, fauna, geology, and the night skies that have a...
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$35.88 one way
$71.77 round trip
$4.09/gal25.4 MPG avg78 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.50
$39.48
$78.96
premium
$4.86
$42.68
$85.37
diesel
$5.61
$49.21
$98.43
Estimated Tolls: $0.70
Maine Turnpike
(11.6 mi)$0.70
Toll estimates based on average 2024-2025 rates. EZ-Pass/SunPass discounts may lower the actual cost.
Estimated Trip Cost (one way, 1 person)
Fuel
$36
Tolls
$1
Meals
$25–$50
Total
$62–$87
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 78 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $23 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
66.9
0
$23.40
$10.70
Efficient EV
55.7
0
$19.50
$8.92
EV Truck/SUV
89.2
1
$31.21
$14.27
Gas CO2
78 kg
EV CO2
26 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 16, 2026
Origin
Medway, ME
Late night
in Medway on Saturday
Local time
3:09 AM
EDT
Current temp
50°F
Unavailable
Live forecast
Destination
Sanford, ME
Late night
in Sanford on Saturday
Local time
3:09 AM
EDT
Current temp
51°F
Unavailable
Live forecast
46°F
Brunswick, ME
111 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 10m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Medway, ME to Sanford, ME covers 222.9 miles and takes about 4h 10m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 95, I 295, Maine Turnpike. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 111.5 miles from Medway, ME. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $35.88 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This drive requires moderate attention. Across 222.9 miles you will encounter 9 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: at 0.3 miles (ME 157 / Medway Road): Navigation decision point; at 142 miles (I 295): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 192.6 miles (I 295): Highway fork - watch signs carefully.
On the drive from Medway, ME to Sanford, ME, road signs begin pointing toward Brunswick along the way.
Yes. Nearby national parks include Frances Perkins National Monument and Katahdin Woods and Waters National Monument.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.
