Origin
Mission, TX
Morning in Mission on Monday
Local time
9:23 AM
CDT
Current temp
81°F
Unavailable
Live forecast
Trip from Mission, TX to Amarillo, TX
Drive Time
13h 22m
Distance
751.5 mi
1,209 km
Drive Score
8/10
Great drive
Same Day?
2-day trip
Fuel Cost
$115
one way
EV Charging
Loading...
station data
Best Time to Leave
4 AM
13h 10m
★
6 AM
13h 22m
8 AM
13h 46m
10 AM
13h 31m
12 PM
13h 28m
3 PM
13h 32m
5 PM
13h 45m
8 PM
13h 15m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Mission, TX
Mark Direen
Amarillo, TX
Wikimedia Commons
Trip Overview
The drive from Mission, TX to Amarillo, TX covers 751.5 miles and takes about 13h 22m behind the wheel. It usually feels better as a 2-day road trip than as one long push.
The route leans on US 281, Marshall Formby Memorial Highway, I 10 for much of the mileage, and the overall profile is long-distance drive. The longest uninterrupted segment is about 125.7 miles on US 281. At current regular gas prices, budget about $114.80 one way before food or hotel costs.
Trip Pace
Best split across 2 days
Treat the return leg as its own travel day rather than an afterthought.
Break Rhythm
3 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
375.7 miles from Mission, TX
A natural place for your longest stop of the day , about 6h 45m into the drive .
Drive Character
At 751.5 miles and 13h 22m of driving, this is a route where fuel stops, weather, and timing matter more than any single turn. The main roads are US 281 and Marshall Formby Memorial Highway.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 54 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 281 is the longest continuous segment at about 125.7 miles.
How Hard Is This Drive?
At 13h 22m, this is a long-haul route where pacing matters more than any single turn. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 10 miles in.
Route Complexity
10/10
High effort - long or complex enough to need steady focus all day
This is a demanding drive. With 39 significant decision points across 751.5 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 10 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 243.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 245.2 miles (I 10; US 87 / McDermott Freeway): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 39 key pointsThese are the spots where you need to pay the most attention. Preview them before you drive.
6
10 mi into trip
|
~13m in
Take the exit toward I 69C North, US 281: Edinburg
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 416B
Toward I 69C North, US 281: Edinburg
8
243.3 mi into trip
|
~4h 28m in
Take the exit toward Cesar Estrada Chavez Boulevard, Alamodome
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 140B
Toward Cesar Estrada Chavez Boulevard, Alamodom...
8
245.2 mi into trip
|
~4h 32m in
|
I 10; US 87 / McDermott Freeway
Take the exit onto I 10; US 87 / McDermott Freeway toward I 10 West, US 87 North: El Paso
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 156
Toward I 10 West, US 87 North: El Paso
6
246.1 mi into trip
|
~4h 33m in
|
I 10; US 87 / McDermott Freeway
Keep slight left at fork onto I 10; US 87 / McDermott Freeway
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
7
749.8 mi into trip
|
~13h 18m in
|
US 87
Keep slight left at fork onto US 87 toward US 87 North
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left / slight right lanes.
Toward US 87 North
Towns Along This Route
Between Mission, TX and Amarillo, TX, road signs point toward Alamodome, Menard and Lubbock.
Alamodome
243.3 mi in
|
~4h 28m
Menard
359.4 mi in
|
~6h 27m
|
via US 83
Lubbock
512.9 mi in
|
~9h 14m
|
via US 84
Main Roads
| Road | Distance | Duration |
|---|---|---|
| US 281 | 125.7 mi | 2h 11m |
| Marshall Formby Memorial Highway | 109.9 mi | 1h 51m |
| I 10 | 98.7 mi | 1h 37m |
| I 69C | 92 mi | 1h 43m |
| US 84 | 74.5 mi | 1h 14m |
| Frisco Avenue | 41.9 mi | 44m |
| State Highway 153 | 29.5 mi | 33m |
| North Main Street | 29.3 mi | 30m |
Longest stretch:
US 281
— 125.7 mi, about 2h 11m
Turn-by-Turn Driving Directions
Step-by-step road directions between Mission, TX and Amarillo, TX.
1
Start on US 83 Bus
134 ft
·
9 sec
·
East Tom Landry Street
2
Turn left onto TX 107
1.1 mi
·
1 min
·
North Conway Avenue
3
Turn left onto US 83 Exwy Service Road
155 ft
·
3 sec
·
US 83 Exwy Service Road
4
Continue on East Expressway 83
0.6 mi
·
1 min
·
East Expressway 83
5
Take the ramp
0.4 mi
·
46 sec
Toward I 2 East, US 83 East
6
Merge onto I 2; US 83
8.0 mi
·
9 min
·
I 2; US 83
Use the straight / slight right lanes.
7
Take the exit
1.0 mi
·
1 min
Exit 416B
Toward I 69C North, US 281: Edinburg
8
Continue on I 69C
22 mi
·
23 min
·
I 69C
Use the straight / slight right lanes.
9
Continue on US 281
57 mi
·
1 hr
·
US 281
10
Keep slight right at fork onto I 69C; US 281
70 mi
·
1 hr 19 min
·
I 69C; US 281
11
Keep slight left at fork onto US 281
15 mi
·
18 min
·
Nueces Street
12
Continue on US 281
0.2 mi
·
15 sec
·
US 281
13
Take the exit onto US 281
68 mi
·
1 hr 10 min
·
US 281
Use the straight / slight right lanes.
14
Take the exit
0.2 mi
·
27 sec
Exit 140B
Toward Cesar Estrada Chavez Boulevard, Alamodome
Use the slight right lane.
15
Turn left onto East César E. Chávez Boulevard
1.4 mi
·
3 min
·
East César E. Chávez Boulevard
Use the left / straight lanes.
16
Take the ramp
0.2 mi
·
31 sec
Toward I 10 West, I 35 North
17
Merge onto I 10; I 35; US 87
93 ft
·
1 sec
·
South Pan Am Expressway
18
Take the exit onto I 10; US 87
0.9 mi
·
1 min
·
McDermott Freeway
Exit 156
Toward I 10 West, US 87 North: El Paso
Use the straight / slight right lanes.
19
Keep slight left at fork onto I 10; US 87
15 mi
·
17 min
·
McDermott Freeway
Use the straight / slight right lanes.
20
Keep slight right at fork onto I 10; US 87
99 mi
·
1 hr 37 min
·
I 10; US 87
Use the straight / slight left lanes.
21
Take the exit onto US 83
0.3 mi
·
44 sec
·
US 83
Exit 456
Toward US 83 North, US 377: Junction, Menard
22
Turn right onto US 83; US 377
29 mi
·
30 min
·
North Main Street
Use the right lane.
23
Continue on US 83
42 mi
·
44 min
·
Frisco Avenue
24
Continue on US 83
17 mi
·
18 min
·
Roberts Avenue
25
Turn right onto US 67; US 83
387 ft
·
18 sec
·
Hutchings Avenue
Use the right lane.
26
Turn left onto TX 158
6.3 mi
·
7 min
·
North Broadway Street
Use the left lane.
27
Turn right onto FM 2111
12 mi
·
13 min
·
FM 2111
28
Turn left onto TX 153
29 mi
·
33 min
·
State Highway 153
29
Keep slight right at fork onto TX 153
19 ft
·
0 sec
·
State Highway 153
30
Turn right onto TX 70
10 mi
·
10 min
·
State Highway 70
31
Continue on TX 70
0.8 mi
·
1 min
·
Lamar Street
32
Turn left onto Northwest Georgia Avenue
0.1 mi
·
16 sec
·
Northwest Georgia Avenue
33
Take the ramp
340 ft
·
8 sec
Toward I 20 West: Midland
34
Merge onto I 20; US 84
6.0 mi
·
5 min
·
I 20; US 84
35
Take the exit onto US 84
0.3 mi
·
19 sec
·
US 84
Exit 238A
Toward US 84 West: Snyder, Lubbock
36
Keep slight left at fork onto US 84
74 mi
·
1 hr 14 min
·
US 84
37
Turn right onto Loop 46
1.0 mi
·
1 min
·
South Avenue F
38
Keep slight left at fork onto TX 207
0.1 mi
·
10 sec
·
North Avenue F
39
Turn straight onto TX 207
0.4 mi
·
38 sec
·
Ralls Road
40
Turn left onto Spur 575
0.1 mi
·
17 sec
·
East 15th Street
41
Turn right onto US 84
1.0 mi
·
1 min
·
North US Highway 84
42
Continue on US 84
20 mi
·
19 min
·
Highway 84
43
Continue on US 84
4.6 mi
·
4 min
·
Trooper Jerry Don Davis Memorial Highway
44
Continue on US 84
6.8 mi
·
6 min
·
East Highway 84
45
Continue on US 84
4.5 mi
·
5 min
·
Slaton Road
46
Take the exit
0.2 mi
·
26 sec
47
Turn slight right onto Interstate 27
321 ft
·
6 sec
·
Interstate 27
48
Take the ramp
0.2 mi
·
31 sec
49
Merge onto I 27; US 87
110 mi
·
1 hr 51 min
·
Marshall Formby Memorial Highway
50
Continue on I 27; US 60; US 87
13 mi
·
15 min
·
Canyon Expressway
Use the straight / right lanes.
51
Keep slight left at fork onto US 87
0.9 mi
·
2 min
·
US 87
Toward US 87 North
Use the slight left / slight right lanes.
52
Keep slight right at fork onto US 87; Original US Route 66
0.7 mi
·
1 min
·
South Fillmore Street
Use the straight / right lanes.
53
Turn right onto I 40 Business; Original US Route 66; US 60
105 ft
·
1 sec
·
East Amarillo Boulevard
54
Arrive at destination
I 40 Business; Original US Route 66; US 60
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
This drive is better paced as a 2-day trip.
Plan roughly 3 meaningful breaks for fuel, food, and rest.
The halfway point lands around 375.7 miles from Mission, TX, or about 6h 45m into the drive.
The longest continuous stretch on this route runs about 125.7 miles.
Consider an overnight stop or starting very early.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 165 miles or 3h 4m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 375.7 miles or 6h 45m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Overnight split
Day 1 wrap after about 375.7 miles or 6h 45m
Stop before fatigue turns the last few hours into a grind. You want day two to start fresh, not just resumed.
Final approach
Final hour starts around 12h 17m
Traffic, exits, and arrival timing usually matter more near Amarillo, TX than in the middle of the route.
Before You Leave
+
Open the route before leaving Mission, TX so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
+
Treat this as a 2-day road trip and book the overnight stop before the busiest arrival window.
Day 1
Settle into the route from Mission, TX
Aim for roughly 376 miles and 6.7 hours of wheel time on this day.
Day 2
Finish the approach into Amarillo, TX
Aim for roughly 376 miles and 6.7 hours of wheel time on this day.
Your first comfortable stop window is around 165 miles from Mission, TX.
This route usually feels better as a 2-day drive than as one long push.
Plan about 3 real breaks rather than only quick fuel stops.
The longest stretch is on US 281 for about 125.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 375.7 mi from Mission, TX · 6h 45m into the drive
First major stop
Coffee and fuel
248 mi into the route
Best for: Coffee, fuel, and an easy first stretch
This is a natural early stop once the first hours of the drive are behind you.
Second major stop
Overnight candidate
496 mi into the route
Best for: Hotel check-in, dinner, and a fresh start
This lines up well with a realistic day-end stop if you are breaking the drive into stages.
Find hotels in Sweetwater, TXOvernight Options
Night 1
376 mi · about 6.7h in
A practical overnight split lands near Kerrville, TX after about 376 miles or 6.7 hours of driving.
Find hotelsPacing Suggestions
Fuel and coffee
A short stop after about 165 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 375.7 miles from Mission, TX, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before US 281 if your tank is already low. That segment runs about 125.7 miles.
Overnight split
Hotel stopFor a steadier pace, wrap day one after about 376 miles or 6.7 hours on the road.
Arriving in Amarillo, TX
The final approach into Amarillo, TX usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Amarillo, TX.
On a multi-day trip, keep the last day a little lighter so you reach Amarillo, TX with some flexibility left in the schedule.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$114.80 one way
$229.59 round trip
$3.88/gal
25.4 MPG avg
263 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.25 | $125.80 | $251.60 |
| premium | $4.59 | $135.83 | $271.66 |
| diesel | $5.64 | $166.96 | $333.91 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$115
Hotel (1n)
$80–$140
Meals
$50–$100
Total
$245–$355
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 262.9 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $79 in charging · 2 stops · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 225.5 | 2 | $78.91 | $36.07 |
| Efficient EV | 187.9 | 2 | $65.76 | $30.06 |
| EV Truck/SUV | 300.6 | 3 | $105.21 | $48.10 |
Gas CO2
263 kg
EV CO2
88 kg (67% less)
Plan for 2 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Amarillo, TX
Morning in Amarillo on Monday
Local time
9:23 AM
CDT
Current temp
46°F
Unavailable
Live forecast
Along the Route
55°F
Sweetwater, TX
496 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
For long drives, weather on day two can matter just as much as conditions at departure, so check the whole travel window rather than only the first day.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
35 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
13h 22m on the road
This is long enough that the arrival forecast matters almost as much as departure conditions. Recheck both ends before you roll.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Mission, TX to Amarillo, TX covers 751.5 miles and takes about 13h 22m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 281, Marshall Formby Memorial Highway, I 10. Expect a mix of highway and local road driving.
Consider an overnight stop or starting very early.
Yes. This route is usually more comfortable as a 2-day drive. A sensible stopping point is after roughly 376 miles on day one.
The midpoint is about 375.7 miles from Mission, TX. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $114.80 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 3 meaningful breaks for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 39 significant decision points across 751.5 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 10 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 243.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 245.2 miles (I 10; US 87 / McDermott Freeway): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Mission, TX and Amarillo, TX, road signs point toward Alamodome, Menard and Lubbock.
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