Origin
Mosinee, WI
Night in Mosinee on Friday
Local time
9:17 PM
CDT
Current temp
42°F
Unavailable
Compiled and reviewed by the Trip.ovh planning team at COD Solutions Oy · Last reviewed Apr 18, 2026 · Editorial standards
Drive Time
3h 1m
Distance
131.7 mi
212 km
Drive Score
9/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$21
one way
EV Charging
Unknown
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Mosinee, WI
Роман Красовский
La Crosse, WI
Wikimedia Commons
Mosinee to La Crosse is 131.7 miles and takes about 3 hours 1 minute via I 90, with a fuel budget near $21 and enough daylight to finish in a day. This trip stays within Wisconsin, moving from the Midwest region to the Midwest region. It's a straightforward drive, primarily on the interstate, making it a practical choice for a single-day journey. You'll find this route efficient for getting from point A to point B with minimal fuss.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
65.9 miles from Mosinee, WI
A natural place for your longest stop of the day , about 1h 36m into the drive .
Weekend Trip
Doable as a same-day drive at 3h 1m. Total distance: 131.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
3h 1m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (79%). Some complex stretches to watch for.
This is largely a highway-focused drive, with 79% of the route utilizing major highways like I 90. You can expect longer stretches of consistent speed, including one segment of 38.1 miles on I 90 where you'll maintain momentum. While the majority is interstate, there are portions on State Highway 173 and Victory Road that might offer a slight change of pace before returning to faster highway travel. The overall feel is one of steady progress across the landscape.
This is a straightforward highway drive that stays mostly on I 90 and State Highway 173. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.9 miles in near WI 153 / State Highway 153.
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 26 significant decision points across 131.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.9 miles (WI 153 / State Highway 153): Lane positioning matters here; at 5 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 19.3 miles (WI 34): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
These are the spots where you need to pay the most attention. Preview them before you drive.
Turn left onto WI 153 / State Highway 153
Lane positioning matters here
Take the exit toward WI 34: Knowlton, Wisconsin Rapids
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Take the exit onto WI 34 toward WI 34 West, WI 13 South: Wisconsin Rapids
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Take the exit toward I 90 West: La Crosse, Albert Lea
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Take the exit toward WI 16: La Crosse, Onalaska
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Mosinee, WI and La Crosse, WI, road signs point toward Albert Lea and Onalaska.
Albert Lea
Onalaska
| Road | Distance | Duration |
|---|---|---|
| I 90 | 38.1 mi | 40m |
| State Highway 173 | 34 mi | 49m |
| Victory Road | 15.2 mi | 22m |
| State Highway 34 | 9.9 mi | 13m |
| WI 16 | 4.9 mi | 8m |
| State Highway 21 | 4.1 mi | 5m |
| US Highway 10 | 3.8 mi | 4m |
| I 39 | 3.3 mi | 3m |
Step-by-step road directions between Mosinee, WI and La Crosse, WI.
Start on CTH B
Turn slight right onto WI 153
Turn straight onto WI 153
Turn left onto WI 153
Take the ramp
Merge onto I 39; US 51
Take the exit
Keep slight right at fork
Turn straight onto WI 34
Enter roundabout onto WI 34; CTH C
Continue on WI 34; CTH C
Take the ramp onto WI 34
Merge onto US 10; WI 34
Take the exit onto WI 34
Turn left onto WI 13; WI 34
Turn right onto WI 54; WI 73
Enter roundabout onto WI 54; WI 73
Continue on WI 54; WI 73
Continue on WI 54; WI 73
Turn right onto WI 54; WI 73
Continue on WI 54
Turn left onto CTH G
Continue on State Highway 173
At end of road, turn left onto WI 80; WI 173
Continue on WI 80; WI 173
Continue on WI 173
Turn right onto WI 21
Continue on WI 21
Continue on WI 21
Take the exit
Merge onto I 94
Take the exit
Merge onto I 90
Take the exit
At end of road, turn left onto WI 16
Continue on Losey Boulevard North
Turn right onto CTH F
Turn left onto 16th Street South
Turn right onto Johnson Street
At end of road, turn right onto WI 35
Arrive at destination
Given the 3-hour duration, this is a perfect one-day trip, so consider leaving in the morning to give yourself ample time. The single recommended stop suggests you can cover a good distance before needing a break. Keep an eye on your fuel, as the estimated cost is $21, and plan your fill-up accordingly, perhaps before the longest stretch on I 90. This route is direct, so you have the flexibility to depart when it's most convenient for you.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 29 miles or 41m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 65.9 miles or 1h 36m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 27m
Traffic, exits, and arrival timing usually matter more near La Crosse, WI than in the middle of the route.
Open the route before leaving Mosinee, WI so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Mosinee, WI
This is one driving day of about 131.7 miles and 3h 1m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 65.9 mi from Mosinee, WI · 1h 36m into the drive
Mid-route town
Meal stop
66 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 29 miles helps settle the day before fatigue starts building.
The midpoint is around 65.9 miles from Mosinee, WI, which is a good place for a longer meal and fuel stop.
The final approach into La Crosse, WI usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around La Crosse, WI.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$20.59 one way
$41.18 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.36 | $22.61 | $45.21 |
| premium | $4.89 | $25.34 | $50.69 |
| diesel | $5.61 | $29.08 | $58.16 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$21
Meals
$25–$50
Total
$46–$71
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 46.1 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $14 in charging · 0 stops · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 39.5 | 0 | $13.83 | $6.32 |
| Efficient EV | 32.9 | 0 | $11.52 | $5.27 |
| EV Truck/SUV | 52.7 | 0 | $18.44 | $8.43 |
Gas CO2
46 kg
EV CO2
15 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Current conditions at both ends of the drive.
Origin
Night in Mosinee on Friday
Local time
9:17 PM
CDT
Current temp
42°F
Unavailable
Destination
Night in La Crosse on Friday
Local time
9:17 PM
CDT
Current temp
66°F
Unavailable
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, and EIA for fuel prices. See our methodology for refresh cadence and limitations.
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