Drive Time
7h 14m
Distance
376.6 mi
606 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$58
one way
Photo: 大 董
Traveling from Moss Point to Southaven covers 376.6 miles across the state of Mississippi, a journey that typically takes about 7 hours and 14 minutes. Because this route is almost entirely highway-focused, you can comfortably complete the drive in a single day, though it will be a substantial time commitment behind the wheel. Expect to budget approximately $58 for fuel to make the trip. You will traverse the Southeast region from the coast toward the northern border, transitioning from the Gulf area to the Memphis metropolitan vicinity. It is a straightforward, practical transit route that works well if you are looking to get from point A to point B efficiently without unnecessary detours.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
188.3 miles from Moss Point, MS
A natural place for your longest stop of the day , about 3h 48m into the drive .
With 99% of your time spent on highways, this trip is defined by a consistent, high-speed pace rather than winding backroads. You will navigate a combination of I-10, US-49, and I-55 to complete your journey. The most significant portion of the drive is a 195.7-mile stretch on I-55, which serves as the primary artery for the latter half of your trip. You should expect a classic interstate experience characterized by steady cruising and limited technical driving. This configuration makes for a predictable ride, allowing you to cover the distance quickly while staying almost exclusively on major thoroughfares.
This is a straightforward highway drive that stays mostly on I 55 and US 49. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.3 miles in near MS 613 / Main Street.
High effort - long or complex enough to need steady focus all day
This is a demanding drive. With 19 significant decision points across 376.6 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.3 miles (MS 613 / Main Street): Navigation decision point; at 23.1 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 23.3 miles: Highway fork - watch signs carefully.
These are the spots where you need to pay the most attention. Preview them before you drive.
At end of road, turn right onto MS 613 / Main Street
Navigation decision point
Take the exit toward I 110, MS 15, MS 67: Biloxi, Keesler Air Force Base
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Keep slight left at fork
Highway fork - watch signs carefully
Keep slight right at fork toward MS 15, MS 67: MS 15, MS 67
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Between Moss Point, MS and Southaven, MS, road signs point toward Keesler Air Force Base and Jackson.
Keesler Air Force Base
Jackson
| Road | Distance | Duration |
|---|---|---|
| I 55 | 195.7 mi | 3h 31m |
| US 49 | 135 mi | 2h 46m |
| I 10 | 20.6 mi | 22m |
| Biloxi-D'Iberville Scenic Expressway | 20.4 mi | 23m |
| Main Street | 1.9 mi | 3m |
| Stateline Road West | 0.4 mi | <1m |
| Mc Innis Avenue | 0.3 mi | <1m |
| Millbranch Road | 0.2 mi | <1m |
Step-by-step road directions between Moss Point, MS and Southaven, MS.
Start on this road
Turn right onto Mc Innis Avenue
At end of road, turn right onto MS 613
Take the ramp
Turn left
Merge onto I 10
Take the exit
Keep slight left at fork
Keep slight right at fork
Merge onto MS 15; MS 67
Keep slight right at fork
Merge onto US 49
Continue on US 49
Turn straight onto US 49
Continue on US 49; MS 42
Continue on US 49
Continue on US 49
Continue on US 49
Continue on US 49
Take the exit onto US 49
Keep slight left at fork onto US 49
Keep slight right at fork onto US 49
Merge onto I 55
Take the exit
Turn left onto Stateline Road West
Turn left onto Millbranch Road
Turn right onto Haleville Drive
Turn left onto Five Oaks Drive North
Arrive at destination
To manage the 7-hour and 14-minute duration effectively, plan for at least two intentional stops to stretch your legs and refuel. Since the drive is heavily reliant on I-55, keep an eye on traffic reports for the Memphis area as you approach Southaven, as congestion can fluctuate. Departing early in the morning is your best bet to avoid peak traffic and ensure you reach your destination before fatigue sets in. Because the route is highway-dominated, keep your cruise control ready for the long 195.7-mile stretch on I-55 to maintain a steady speed. Staying flexible with your timing will help you navigate the transition from the coastal region to the northern part of the state with ease.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 83 miles or 1h 37m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 188.3 miles or 3h 48m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 6h 7m
Traffic, exits, and arrival timing usually matter more near Southaven, MS than in the middle of the route.
Open the route before leaving Moss Point, MS so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Pick one backup stop option before the midpoint in case traffic changes your pacing.
Day 1
Settle into the route from Moss Point, MS
This is one driving day of about 376.6 miles and 7h 14m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 188.3 mi from Moss Point, MS · 3h 48m into the drive
Mid-route town
Meal stop
188 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 83 miles helps settle the day before fatigue starts building.
The midpoint is around 188.3 miles from Moss Point, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before I 55 if your tank is already low. That segment runs about 195.7 miles.
The final approach into Southaven, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Southaven, MS.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$57.57 one way
$115.14 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.26 | $63.15 | $126.29 |
| premium | $4.61 | $68.35 | $136.70 |
| diesel | $5.64 | $83.67 | $167.33 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$58
Meals
$25–$50
Total
$83–$108
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 131.8 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $40 in charging · 1 stop · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 113 | 1 | $39.54 | $18.08 |
| Efficient EV | 94.2 | 1 | $32.95 | $15.06 |
| EV Truck/SUV | 150.6 | 1 | $52.72 | $24.10 |
Gas CO2
132 kg
EV CO2
44 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive. If you're planning ahead, check the forecast closer to your travel date.
Origin
Late night in Moss Point on Sunday
Local time
2:29 AM
CDT
Current temp
65°F
Forecast unavailable right now
Destination
Late night in Southaven on Sunday
Local time
2:29 AM
CDT
Current temp
64°F
Forecast unavailable right now
Along the Route
85°F
Magee, MS
188 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Thanks for your feedback!
Your tip has been submitted. Thanks!
/500
Recent Tips
·
Explore more options from Moss Point, MS or browse trips ending in Southaven, MS.
Looking for more statewide routes? Browse MS road trips.
Explore maps for Moss Point, MS or Southaven, MS on MapSof.net.
