Last recalculated Apr 16, 2026
Drive Time
5h 47m
Distance
309 mi
497 km
Drive Score
10/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$48
one way
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Mound City, MO
Wikimedia Commons
O'Fallon, MO
Wikimedia Commons
The drive from Mound City, MO to O'Fallon, MO covers 309 miles and takes about 5h 47m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Dwight D. Eisenhower Highway, I 29, U.S. Submarine Veterans' Memorial Highway for much of the mileage, and the overall profile is mixed drive. The longest uninterrupted segment is about 142.5 miles on Dwight D. Eisenhower Highway. At current regular gas prices, budget about $48.31 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
154.5 miles from Mound City, MO
A natural place for your longest stop of the day , about 2h 49m into the drive .
The drive from Mound City, MO to O'Fallon, MO covers 309 miles and takes about 5h 47m, using a mix of highways and local roads.
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 70.1 miles in near I 435.
Demanding - plan breaks and stay ahead of the key maneuvers
This is a demanding drive. With 15 significant decision points across 309 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 70.1 miles (I 435): Highway fork - watch signs carefully. Lane positioning matters here; at 98.1 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 98.4 miles: Highway fork - watch signs carefully. Lane positioning matters here.
These are the spots where you need to pay the most attention. Preview them before you drive.
Keep slight right at fork onto I 435 toward I 435 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Keep slight right at fork onto US 24 toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Keep slight left at fork toward I 70 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Keep slight left at fork toward I 70 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Take the exit toward MO K: O'Fallon
Exit ramp - move to the correct lane early. Lane positioning matters here
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Mound City, MO and O'Fallon, MO, road signs point toward Kansas City and Sports Complex.
Kansas City
Sports Complex
| Road | Distance | Duration |
|---|---|---|
| Dwight D. Eisenhower Highway | 142.5 mi | 2h 42m |
| I 29 | 69.4 mi | 1h 14m |
| U.S. Submarine Veterans' Memorial Highway | 54.4 mi | 58m |
| I 435 | 28 mi | 30m |
| Truman/Eisenhower Presidential Highway | 5.6 mi | 6m |
| Sheriff Roger I. Wilson Memorial Highway | 1.9 mi | 2m |
| Clifton J. Scott Memorial Highway | 1.8 mi | 2m |
| Highway Patrol Sgt. Benjamin Booth Memorial Highway | 1.6 mi | 1m |
Step-by-step road directions between Mound City, MO and O'Fallon, MO.
Start on this road
Turn right onto US 59
Turn left onto MO 118
Take the ramp
Merge onto I 29
Merge onto I 29; I 435; US 71
Keep slight right at fork onto I 435
Keep slight right at fork onto US 24
Keep slight left at fork
Keep slight left at fork
Merge onto I 70
Continue on I 70
Continue on I 70
Continue on I 70
Continue on I 70
Continue on I 70; US 40
Keep slight left at fork onto I 70
Continue on I 70; US 40
Continue on I 70; US 40
Continue on I 70; US 40
Continue on I 70; US 40
Take the exit
Turn straight onto Drennen Parkway
Keep slight right at fork onto Drennen Parkway
Turn slight left
Continue on South Main Street
Turn right
Arrive at destination
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 68 miles or 1h 14m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 154.5 miles or 2h 49m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 40m
Traffic, exits, and arrival timing usually matter more near O'Fallon, MO than in the middle of the route.
Open the route before leaving Mound City, MO so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Mound City, MO
This is one driving day of about 309 miles and 5h 47m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 154.5 mi from Mound City, MO · 2h 49m into the drive
Mid-route town
Meal stop
155 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 68 miles helps settle the day before fatigue starts building.
The midpoint is around 154.5 miles from Mound City, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before Dwight D. Eisenhower Highway if your tank is already low. That segment runs about 142.5 miles.
The final approach into O'Fallon, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around O'Fallon, MO.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$48.31 one way
$96.62 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.36 | $53.04 | $106.08 |
| premium | $4.89 | $59.46 | $118.93 |
| diesel | $5.61 | $68.22 | $136.45 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$48
Meals
$25–$50
Total
$73–$98
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 108.1 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $32 in charging · 1 stop · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 92.7 | 1 | $32.45 | $14.83 |
| Efficient EV | 77.3 | 0 | $27.04 | $12.36 |
| EV Truck/SUV | 123.6 | 1 | $43.26 | $19.78 |
Gas CO2
108 kg
EV CO2
36 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Current conditions at both ends of the drive.
Origin
Night in Mound City on Wednesday
Local time
11:27 PM
CDT
Current temp
83°F
Partly Sunny
Destination
Night in O'Fallon on Wednesday
Local time
11:27 PM
CDT
Current temp
57°F
Unavailable
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
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