The drive from Niles, IL to Murphysboro, IL covers 348.7 miles and takes about 6h 38m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 57, Ken Gray Expressway, Russell Street for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 266.5 miles on I 57.
At current regular gas prices, budget about $54.52 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
174.3 miles from Niles, IL
A natural place for your longest stop of the day
, about 3h 19m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 38m. Total distance: 348.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 38m drive, plan rest stops for pacing.
Drive Character
This is a 6h 38m highway drive covering 348.7 miles, with most of the trip on I 57 and Ken Gray Expressway. The longest continuous stretch is about 266.5 miles on I 57.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 22 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 57 is the longest continuous segment at about 266.5 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 57 and Ken Gray Expressway. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 3.5 miles in.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 13 significant decision points across 348.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 3.5 miles: Lane positioning matters here; at 3.7 miles (I 94 / Edens Expressway): Merge point - match speed before joining. Lane positioning matters here; at 16.4 miles (I 90; I 94 / Dan Ryan Expressway (Express)): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 13 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
5
3.5 mi into trip|~5m in
Take the ramp toward I 94 East
Lane positioning matters here
Use the straight / slight right lanes.
Toward I 94 East
5
3.7 mi into trip|~6m in|I 94 / Edens Expressway
Merge onto I 94 / Edens Expressway
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
8
16.4 mi into trip|~23m in|I 90; I 94 / Dan Ryan Expressway (Express)
Keep slight left at fork onto I 90; I 94 / Dan Ryan Expressway (Express) toward I 90 Express, I 94 Express
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 90 Express, I 94 Express
8
25.2 mi into trip|~35m in|I 57
Keep slight right at fork onto I 57 toward I 57 South: Memphis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Exit 63
Toward I 57 South: Memphis
5
226 mi into trip|~4h 15m in|I 57
Keep slight left at fork onto I 57 toward I 57 South: Memphis
Highway fork - watch signs carefully
Toward I 57 South: Memphis
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Niles, IL and Murphysboro, IL, road signs point toward Johnston City and Herrin.
Johnston City
324.4 mi in|~6h 1m
Herrin
324.4 mi in|~6h 1m
Main Roads
Road
Distance
Duration
I 57
266.5 mi
4h 51m
Ken Gray Expressway
32.7 mi
35m
Russell Street
11.3 mi
15m
Dan Ryan Expressway (Express)
8.8 mi
11m
Kennedy Expressway
8.1 mi
11m
Herrin Road
6.6 mi
9m
East Herrin Street
3.1 mi
5m
North Caldwell Avenue
2.9 mi
4m
Longest stretch:
I 57
— 266.5 mi, about 4h 51m
Turn-by-Turn Driving Directions
Step-by-step road directions between Niles, IL and Murphysboro, IL.
1
Start on North Waukegan Road
14 ft·4 sec·North Waukegan Road
2
Turn right onto West Howard Street
0.6 mi·1 min·West Howard Street
3
Turn right onto US 14
2.9 mi·4 min·North Caldwell Avenue
4
Take the ramp
0.3 mi·35 sec
Toward I 94 EastUse the straight / slight right lanes.
5
Merge onto I 94
2.1 mi·2 min·Edens Expressway
Use the straight / slight right lanes.
6
Continue on I 90; I 94
8.1 mi·11 min·Kennedy Expressway
Use the straight / slight left lanes.
7
Continue on I 90; I 94
2.4 mi·2 min·Dan Ryan Expressway
Use the straight / slight right lanes.
8
Keep slight left at fork onto I 90; I 94
8.8 mi·11 min·Dan Ryan Expressway (Express)
Toward I 90 Express, I 94 ExpressUse the straight / slight right lanes.
9
Keep slight right at fork onto I 57
201 mi·3 hr 40 min·I 57
Exit 63Toward I 57 South: MemphisUse the slight right lane.
10
Keep slight left at fork onto I 57
66 mi·1 hr 10 min·I 57
Toward I 57 South: Memphis
11
Keep slight right at fork onto I 57
33 mi·35 min·Ken Gray Expressway
12
Take the exit
0.3 mi·38 sec
Toward Johnston City, Herrin
13
Turn right onto Herrin Road
3.1 mi·4 min·Herrin Road
14
Continue on East Herrin Street
3.1 mi·5 min·East Herrin Street
15
Continue on Herrin Road
3.5 mi·5 min·Herrin Road
16
Enter roundabout onto Cambria Road
35 ft·0 sec·Cambria Road
17
Continue on Cambria Road
1.5 mi·2 min·Cambria Road
18
Turn left onto IL 149
11 mi·15 min·Russell Street
19
Turn left onto IL 13; IL 127; IL 149
0.9 mi·1 min·North 2nd Street
20
Turn right onto IL 127; IL 149
0.6 mi·1 min·Walnut Street
21
Turn right onto North 11th Street
65 ft·2 sec·North 11th Street
22
Arrive at destination
North 11th Street
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 174.3 miles from Niles, IL, or about 3h 19m into the drive.
The longest continuous stretch on this route runs about 266.5 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 77 miles or 1h 32m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 174.3 miles or 3h 19m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 23m
Traffic, exits, and arrival timing usually matter more near Murphysboro, IL than in the middle of the route.
Before You Leave
+
Open the route before leaving Niles, IL so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Niles, IL
This is one driving day of about 348.7 miles and 6h 38m.
Your first comfortable stop window is around 77 miles from Niles, IL.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 57 for about 266.5 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 174.3 mi from Niles, IL
· 3h 19m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Pullman National Historical Park
National Historical Park
In a growing Chicago neighborhood, diverse people and stories intertwined. All were seeking opportunity. Some succeeded. Others were limited—by race, gender, or economic status. Their stories came tog...
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$54.52 one way
$109.03 round trip
$3.97/gal25.4 MPG avg122 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$59.86
$119.71
premium
$4.89
$67.10
$134.21
diesel
$5.61
$76.99
$153.98
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$55
Meals
$25–$50
Total
$80–$105
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 122 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $37 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
104.6
1
$36.61
$16.74
Efficient EV
87.2
0
$30.51
$13.95
EV Truck/SUV
139.5
1
$48.82
$22.32
Gas CO2
122 kg
EV CO2
41 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Niles, IL
Late night
in Niles on Friday
Local time
4:01 AM
CDT
Current temp
66°F
Unavailable
Live forecast
Destination
Murphysboro, IL
Late night
in Murphysboro on Friday
Local time
4:01 AM
CDT
Current temp
55°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
11 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 38m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Niles, IL to Murphysboro, IL covers 348.7 miles and takes about 6h 38m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 57, Ken Gray Expressway, Russell Street. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 174.3 miles from Niles, IL. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $54.52 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 13 significant decision points across 348.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 3.5 miles: Lane positioning matters here; at 3.7 miles (I 94 / Edens Expressway): Merge point - match speed before joining. Lane positioning matters here; at 16.4 miles (I 90; I 94 / Dan Ryan Expressway (Express)): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Niles, IL and Murphysboro, IL, road signs point toward Johnston City and Herrin.
Yes. Nearby national parks include Pullman National Historical Park.
How this page is built
Compiled and maintained by the Trip.ovh planning team at COD Solutions Oy (Helsinki). Each route is built from authoritative open government and mapping datasets rather than crowdsourced reviews. Distances and geometry come from
OSRM
over
OpenStreetMap.
Fuel cost uses
EIA
weekly regional averages.
National park proximity is from the
NPS API.
Pages are published only after passing our data-quality checks; our
methodology page
documents refresh cadence, editorial standards, and known limitations.
