Origin
Oxford, MS
Morning in Oxford on Thursday
Local time
10:29 AM
CDT
Current temp
80°F
Unavailable
Live forecast
Trip from Oxford, MS to Clarksdale, MS
Last recalculated Apr 16, 2026
Drive Time
5h 30m
Distance
252 mi
406 km
Drive Score
9/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$38
one way
EV Charging
Unknown
Best Time to Leave
4 AM
5h 17m
★
6 AM
5h 30m
8 AM
5h 57m
10 AM
5h 40m
12 PM
5h 37m
3 PM
5h 41m
5 PM
5h 56m
8 PM
5h 22m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Oxford, MS
Wikimedia Commons
Clarksdale, MS
Wikimedia Commons
Trip Overview
The drive from Oxford, MS to Clarksdale, MS covers 252 miles and takes about 5h 30m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on I 55, US 49W, South Highway 61 for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 53.4 miles on I 55. At current regular gas prices, budget about $38.06 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
126 miles from Oxford, MS
A natural place for your longest stop of the day , about 2h 44m into the drive .
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 30m. Total distance: 252 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 30m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (72%). Some complex stretches to watch for.
Drive Character
This is a 5h 30m highway drive covering 252 miles, with most of the trip on I 55 and US 49W. The longest continuous stretch is about 53.4 miles on I 55.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 27 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 55 is the longest continuous segment at about 53.4 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 55 and US 49W. You will hit about 21 points where you need to pay attention to lane position or signs. The trickiest moment comes around 95.2 miles in.
Driving Effort
6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 252 miles you will encounter 21 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 95.2 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 95.4 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 98 miles (US 49): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 21 key pointsThese are the spots where you need to pay the most attention. Preview them before you drive.
7
95.2 mi into trip
|
~2h 6m in
Take the exit toward I 20 West, US 49 North: Vicksburg, Yazoo City
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 92C
Toward I 20 West, US 49 North: Vicksburg, Yazoo...
7
95.4 mi into trip
|
~2h 6m in
Keep slight left at fork toward I 20 West, US 49 North: Vicksburg, Yazoo City
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 West, US 49 North: Vicksburg, Yazoo...
5
98 mi into trip
|
~2h 10m in
|
US 49
Take the exit onto US 49 toward I 220 North, I 49 North: North Jackson, Yazoo City
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward I 220 North, I 49 North: North Jackson,...
5
143 mi into trip
|
~3h 5m in
|
US 49W
Take the exit onto US 49W toward US 49W North, MS 3 South: Indianola, Vicksburg
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward US 49W North, MS 3 South: Indianola, Vic...
5
252 mi into trip
|
~5h 30m in
|
Edwards Alley
Turn right onto Edwards Alley
Navigation decision point
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Oxford, MS and Clarksdale, MS, road signs point toward Yazoo City and Vicksburg.
Yazoo City
95.2 mi in
|
~2h 6m
Vicksburg
143 mi in
|
~3h 5m
|
via US 49W
Main Roads
| Road | Distance | Duration |
|---|---|---|
| I 55 | 53.4 mi | 57m |
| US 49W | 46.7 mi | 56m |
| South Highway 61 | 43.9 mi | 54m |
| Medgar Evers Boulevard | 39.5 mi | 48m |
| US 84 | 22.9 mi | 26m |
| North Sunflower Avenue | 13.5 mi | 23m |
| Gloster Road | 6.5 mi | 15m |
| Oxford-Meadville Road | 6.3 mi | 15m |
Longest stretch:
I 55
— 53.4 mi, about 57m
Turn-by-Turn Driving Directions
Step-by-step road directions between Oxford, MS and Clarksdale, MS.
1
Start on Oxford-Meadville Road
6.3 mi
·
15 min
·
Oxford-Meadville Road
2
Continue on Gloster Road
2.8 mi
·
6 min
·
Gloster Road
3
At end of road, turn left onto Gloster Road
3.8 mi
·
9 min
·
Gloster Road
4
Continue on Yap 3 Road
2.6 mi
·
6 min
·
Yap 3 Road
5
Turn left onto US 98
1.8 mi
·
2 min
·
United States Highway 98
6
Turn right onto MS 184
1.4 mi
·
2 min
·
Old US Hwy 84
7
Turn right onto US 84
23 mi
·
26 min
·
US 84
8
Take the exit
0.2 mi
·
27 sec
9
Merge onto I 55
53 mi
·
57 min
·
I 55
10
Keep slight right at fork onto I 55
0.2 mi
·
13 sec
·
I 55
11
Take the exit
0.2 mi
·
22 sec
Exit 92C
Toward I 20 West, US 49 North: Vicksburg, Yazoo City
12
Keep slight left at fork
0.2 mi
·
29 sec
Toward I 20 West, US 49 North: Vicksburg, Yazoo City
13
Merge onto I 20; US 49
2.4 mi
·
2 min
·
I 20; US 49
14
Take the exit onto US 49
5.2 mi
·
6 min
·
US 49
Toward I 220 North, I 49 North: North Jackson, Yazoo City
15
Take the exit onto US 49
0.3 mi
·
33 sec
·
US 49
Toward US 49 North: Yazoo City
16
Merge onto US 49
39 mi
·
48 min
·
Medgar Evers Boulevard
17
Take the exit onto US 49W
47 mi
·
56 min
·
US 49W
Toward US 49W North, MS 3 South: Indianola, Vicksburg
18
Turn left onto US 82
0.7 mi
·
1 min
·
US 82
19
Turn right onto MS 448
13 mi
·
23 min
·
North Sunflower Avenue
20
Turn left onto MS 448
1.1 mi
·
2 min
·
MS 448
21
Turn right onto US 61; US 278
44 mi
·
54 min
·
South Highway 61
22
Turn left onto MS 161
2.1 mi
·
3 min
·
MS 161
23
Turn left onto Madison Avenue
0.4 mi
·
1 min
·
Madison Avenue
24
Turn right onto 4th Street
0.3 mi
·
55 sec
·
4th Street
25
Turn left onto Issaquena Avenue
436 ft
·
21 sec
·
Issaquena Avenue
26
Turn right onto Edwards Alley
158 ft
·
11 sec
·
Edwards Alley
27
Arrive at destination
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 126 miles from Oxford, MS, or about 2h 44m into the drive.
The longest continuous stretch on this route runs about 53.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 55 miles or 1h 23m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 126 miles or 2h 44m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 31m
Traffic, exits, and arrival timing usually matter more near Clarksdale, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Oxford, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Oxford, MS
This is one driving day of about 252 miles and 5h 30m.
Your first comfortable stop window is around 55 miles from Oxford, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 55 for about 53.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 126 mi from Oxford, MS · 2h 44m into the drive
Mid-route town
Meal stop
126 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 55 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 126 miles from Oxford, MS, which is a good place for a longer meal and fuel stop.
Arriving in Clarksdale, MS
The final approach into Clarksdale, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Clarksdale, MS.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$38.06 one way
$76.12 round trip
$3.84/gal
25.4 MPG avg
88 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.21 | $41.78 | $83.56 |
| premium | $4.56 | $45.23 | $90.46 |
| diesel | $5.61 | $55.64 | $111.28 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$38
Meals
$25–$50
Total
$63–$88
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 88.2 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $26 in charging · 0 stops · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 75.6 | 0 | $26.46 | $12.10 |
| Efficient EV | 63 | 0 | $22.05 | $10.08 |
| EV Truck/SUV | 100.8 | 1 | $35.28 | $16.13 |
Gas CO2
88 kg
EV CO2
29 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Clarksdale, MS
Morning in Clarksdale on Thursday
Local time
10:29 AM
CDT
Current temp
77°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
3 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 30m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Oxford, MS to Clarksdale, MS covers 252 miles and takes about 5h 30m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 55, US 49W, South Highway 61. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 126 miles from Oxford, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $38.06 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This drive requires moderate attention. Across 252 miles you will encounter 21 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: at 95.2 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 95.4 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 98 miles (US 49): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Between Oxford, MS and Clarksdale, MS, road signs point toward Yazoo City and Vicksburg.
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