Drive Time
4h 46m
Distance
306.2 mi
493 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$45
one way
Photo: Ever Rayan
The drive from Perryville, MO to Independence, MO covers 306.2 miles and takes about 4h 46m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on East Saint Joseph Street, North Main Street, North Kingshighway Street for much of the mileage, and the overall profile is turn-heavy local drive. At current regular gas prices, budget about $45.46 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
153.1 miles from Perryville, MO
A natural place for your longest stop of the day , about 2h 23m into the drive .
Expect a 4h 46m drive with frequent turns across 306.2 miles of local and secondary roads.
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. Navigation is very simple — set it and forget it for most of the drive.
Very easy — mostly straight driving
Navigation is easy, but the length (4h 46m) means fatigue is the real challenge. The route is 0% highway with very few tricky spots.
Where does it get tricky?
This route does not have any notably tricky sections. Most of the drive from Perryville, MO to Independence, MO is straightforward, with well-signed roads and simple exits.
| Road | Distance | Duration |
|---|---|---|
| East Saint Joseph Street | Unavailable | Refreshing |
| North Main Street | Unavailable | Refreshing |
| North Kingshighway Street | Unavailable | Refreshing |
| North King's Highway | Unavailable | Refreshing |
| I 55 North | Unavailable | Refreshing |
| Rosa Parks Highway | Unavailable | Refreshing |
| I 270 West | Unavailable | Refreshing |
| I 64 | Unavailable | Refreshing |
Per-road distance and duration are being refreshed from OSRM for this route.
Step-by-step road directions between Perryville, MO and Independence, MO.
Start on South Spring Street
Turn left onto East Saint Joseph Street
Turn right onto North Main Street
Continue on North Main Street
Enter the roundabout and take exit 3 toward North Kingshighway Street
Exit the roundabout onto North Kingshighway Street
Continue on North King's Highway
Turn left
Take the ramp right toward I 55 North: Saint Louis
Merge slight left
Continue on Rosa Parks Highway
Take the exit slight right toward I 270 West, I 255 East: Kansas City, Chicago
Keep slight left to continue on I 270 West: Kansas City
Continue on I 270 West
Merge slight left
Take the exit slight right toward I 64, US 40, US 61: Wentzville, Saint Louis
Keep slight left to continue on I 64 West, US 40 West, US 61 North: Wentzville
Continue on I 64 West, US 40 West, US 61 North: Wentzville
Merge slight left onto Avenue of the Saints
Take the exit slight left toward I 70 West, US 40 West: Kansas City
Merge slight left onto Dwight D Eisenhower Highway
Continue on Sheriff Roger I. Wilson Memorial Highway
Continue on Highway Patrol Sgt. Benjamin Booth Memorial Highway
Continue on Dwight D. Eisenhower Highway
Continue on U.S. Submarine Veterans' Memorial Highway
Continue on Dwight D. Eisenhower Highway
Continue on Truman/Eisenhower Presidential Highway
Continue on Clifton J. Scott Memorial Highway
Take the exit slight right toward Noland Road
Turn right onto South Noland Road
Turn left onto East Walnut Street
Turn right onto South Lynn Street
Turn left onto East Kansas Avenue
Arrive at your destination
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 14m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 153.1 miles or 2h 23m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 54m
Traffic, exits, and arrival timing usually matter more near Independence, MO than in the middle of the route.
Open the route before leaving Perryville, MO so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Perryville, MO
This is one driving day of about 306.2 miles and 4h 46m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 153.1 mi from Perryville, MO · 2h 23m into the drive
Mid-route town
Meal stop
153 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 80 miles helps settle the day before fatigue starts building.
The midpoint is around 153.1 miles from Perryville, MO, which is a good place for a longer meal and fuel stop.
The final approach into Independence, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Independence, MO.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$45.46 one way
$90.92 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.25 | $51.27 | $102.54 |
| premium | $4.65 | $56.10 | $112.21 |
| diesel | $5.30 | $63.94 | $127.88 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$45
Meals
$25–$50
Total
$70–$95
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 107.1 kg one way.
Driving Electric?
About $32 in charging · 1 stop · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 91.9 | 1 | $32.15 | $14.70 |
| Efficient EV | 76.6 | 0 | $26.79 | $12.25 |
| EV Truck/SUV | 122.5 | 1 | $42.87 | $19.60 |
Gas CO2
107 kg
EV CO2
36 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive. If you're planning ahead, check the forecast closer to your travel date.
Origin
Afternoon in Perryville on Saturday
Local time
12:30 PM
CDT
Current temp
79°F
Forecast unavailable right now
Destination
Afternoon in Independence on Saturday
Local time
12:30 PM
CDT
Current temp
49°F
Forecast unavailable right now
Along the Route
57°F
Alton, IL
153 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
An early start around 7-8 AM gets you there with plenty of daylight left.
Thanks for your feedback!
Your tip has been submitted. Thanks!
/500
Recent Tips
·
Explore more options from Perryville, MO or browse trips ending in Independence, MO.
Looking for more statewide routes? Browse MO road trips.
Explore maps for Perryville, MO or Independence, MO on MapSof.net.
