Trip from Port Saint Lucie, FL to Key West, FL

Drive Time

6h 4m

Distance

272.9 mi

439 km

Drive Score

10/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$46

one way

EV Charging

Loading...

station data

Best Time to Leave

Save up to 39 min

4 AM

5h 52m ★

6 AM

6h 5m

8 AM

6h 31m

10 AM

6h 14m

12 PM

6h 11m

3 PM

6h 15m

5 PM

6h 29m

8 PM

5h 57m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Best Time Drive vs Fly

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Trip Overview

The drive from Port Saint Lucie, FL to Key West, FL covers 272.9 miles and takes about 6h 4m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.

The route leans on Overseas Highway, Florida's Turnpike, Homestead Extension of Florida's Turnpike for much of the mileage, and the overall profile is mixed drive. The longest uninterrupted segment is about 104.2 miles on Overseas Highway. At current regular gas prices, budget about $45.59 one way before food or hotel costs.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

136.4 miles from Port Saint Lucie, FL

A natural place for your longest stop of the day , about 2h 36m into the drive .

Drive Character

The drive from Port Saint Lucie, FL to Key West, FL covers 272.9 miles and takes about 6h 4m, using a mix of highways and local roads.

Expect a mix of faster highway mileage and slower local approaches near the beginning or end.

There are about 15 navigation steps in the underlying route data, so the final approach matters more than the middle miles.

Overseas Highway is the longest continuous segment at about 104.2 miles.

How Hard Is This Drive?

This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 3.1 miles in.

Route Complexity 8/10

Demanding - plan breaks and stay ahead of the key maneuvers

This is a demanding drive. With 10 significant decision points across 272.9 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: at 3.1 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 3.6 miles (Florida's Turnpike): Merge point - match speed before joining. Lane positioning matters here; at 99.1 miles (Homestead Extension of Florida's Turnpike): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.

Critical Maneuvers

5 of 10 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

8

3.1 mi into trip | ~5m in

Keep slight left at fork toward Miami, Florida's Turnpike South

Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight left lane. Toward Miami, Florida's Turnpike South

5

3.6 mi into trip | ~7m in | Florida's Turnpike

Merge onto Florida's Turnpike

Merge point - match speed before joining. Lane positioning matters here

Use the straight / slight right lanes.

7

99.1 mi into trip | ~1h 52m in | Homestead Extension of Florida's Turnpike

Take the exit onto Homestead Extension of Florida's Turnpike toward Florida's Turnpike Toll South, Homestead

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the straight / slight right lanes. Toward Florida's Turnpike Toll South, Homestead

7

99.3 mi into trip | ~1h 53m in | Homestead Extension of Florida's Turnpike

Keep slight left at fork onto Homestead Extension of Florida's Turnpike toward Homestead

Highway fork - watch signs carefully. Lane positioning matters here

Use the straight / slight right lanes. Toward Homestead

5

146.8 mi into trip | ~2h 48m in | US 1 / Dixie Highway

Merge onto US 1 / Dixie Highway

Merge point - match speed before joining. Lane positioning matters here

Use the left lane.

Towns Along This Route

Between Port Saint Lucie, FL and Key West, FL, road signs point toward Florida's Turnpike Toll South and Homestead.

Florida's Turnpike Toll South

99.1 mi in | ~1h 52m | via Homestead Extension of Florida's Turnpike

Homestead

99.1 mi in | ~1h 52m | via Homestead Extension of Florida's Turnpike

Main Roads

Road	Distance	Duration
Overseas Highway	104.2 mi	2h 42m
Florida's Turnpike	95.5 mi	1h 45m
Homestead Extension of Florida's Turnpike	47.1 mi	54m
Dixie Highway	19.2 mi	26m
North Roosevelt Boulevard	2.4 mi	5m
Southeast Airoso Boulevard	1.6 mi	2m
Southwest Port Saint Lucie Boulevard	0.8 mi	1m
George Street	0.3 mi	1m

Longest stretch: Overseas Highway — 104.2 mi, about 2h 42m

Turn-by-Turn Driving Directions

Step-by-step road directions between Port Saint Lucie, FL and Key West, FL.

1

Start on Southwest Carter Avenue

215 ft · 11 sec · Southwest Carter Avenue

2

Turn right onto CR 615

1.6 mi · 2 min · Southeast Airoso Boulevard

3

Turn right onto FL 716

0.8 mi · 1 min · Southwest Port Saint Lucie Boulevard

4

Turn left onto Southwest Bayshore Boulevard

0.1 mi · 21 sec · Southwest Bayshore Boulevard

5

Take the ramp

0.5 mi · 1 min

Toward Florida's Turnpike Toll

6

Keep slight left at fork

0.5 mi · 1 min

Toward Miami, Florida's Turnpike South Use the slight left lane.

7

Merge onto Florida's Turnpike

96 mi · 1 hr 45 min · Florida's Turnpike

Use the straight / slight right lanes.

8

Take the exit onto Homestead Extension of Florida's Turnpike

0.2 mi · 20 sec · Homestead Extension of Florida's Turnpike

Toward Florida's Turnpike Toll South, Homestead Use the straight / slight right lanes.

9

Keep slight left at fork onto Homestead Extension of Florida's Turnpike

47 mi · 54 min · Homestead Extension of Florida's Turnpike

Toward Homestead Use the straight / slight right lanes.

10

Keep slight left at fork

0.6 mi · 1 min

11

Merge onto US 1

19 mi · 26 min · Dixie Highway

Use the left lane.

12

Continue on US 1

104 mi · 2 hr 42 min · Overseas Highway

Use the straight lane.

13

Turn right onto US 1

2.4 mi · 5 min · North Roosevelt Boulevard

14

Turn left onto George Street

0.3 mi · 1 min · George Street

15

Arrive at destination

George Street

Trip Plan

Morning Departure

Start early — leave by 6-7 AM to arrive at a reasonable hour.

Evening Departure

This is a long drive — plan for a morning departure or consider splitting it into two days.

You can normally do this drive in one day.

Plan roughly 1 meaningful break for fuel, food, and rest.

The halfway point lands around 136.4 miles from Port Saint Lucie, FL, or about 2h 36m into the drive.

The longest continuous stretch on this route runs about 104.2 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 80 miles or 1h 31m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 136.4 miles or 2h 36m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 4h 45m

Traffic, exits, and arrival timing usually matter more near Key West, FL than in the middle of the route.

Before You Leave

+

Open the route before leaving Port Saint Lucie, FL so your first major turns are already loaded.

+

Leave with enough water and a charging cable within reach, not packed away.

+

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Port Saint Lucie, FL

This is one driving day of about 272.9 miles and 6h 4m.

Your first comfortable stop window is around 80 miles from Port Saint Lucie, FL.

This route can stay practical as a one-day drive if traffic stays reasonable.

Plan about 1 real break rather than only quick fuel stops.

The longest stretch is on Overseas Highway for about 104.2 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 136.4 mi from Port Saint Lucie, FL · 2h 36m into the drive

Mid-route town

Meal stop

Miami, FL

136 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Fort Lauderdale, FL

Fuel and coffee

A short stop after about 80 miles helps settle the day before fatigue starts building.

Doral, FL

Meal break

The midpoint is around 136.4 miles from Port Saint Lucie, FL, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before Overseas Highway if your tank is already low. That segment runs about 104.2 miles.

Arriving in Key West, FL

The final approach into Key West, FL usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Key West, FL.

After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$45.59 one way

$91.17 round trip

$4.24/gal 25.4 MPG avg 96 kg CO₂

Fuel Type	$/gal	One Way	Round Trip
midgrade	$4.60	$49.38	$98.76
premium	$4.90	$52.60	$105.21
diesel	$5.64	$60.63	$121.26

Estimated Tolls: $9.51

Florida's Turnpike (95.5 mi) $6.69

Homestead Extension (47.1 mi) $2.82

Toll estimates based on average 2024-2025 rates. EZ-Pass/SunPass discounts may lower the actual cost.

Estimated Trip Cost (one way, 1 person)

Fuel

$46

Tolls

$10

Meals

$25–$50

Total

$80–$105

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 95.5 kg one way. Prices: EIA weekly data, 2026-04-06.

Driving Electric?

About $29 in charging · 1 stop · 66% less CO₂

Vehicle Type	kWh	Stops	DC Fast	Home Charge
Average EV	81.9	1	$28.65	$13.10
Efficient EV	68.2	0	$23.88	$10.92
EV Truck/SUV	109.2	1	$38.21	$17.47

Gas CO2

95 kg

EV CO2

32 kg (66% less)

Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 2 hours ago

Origin

Port Saint Lucie, FL

Morning in Port Saint Lucie on Monday

Local time

6:47 AM

EDT

Current temp

64°F

Partly Cloudy

E 5 to 10 mph 0% chance Live forecast

Rip Current Statement

Rip Current Statement issued April 13 at 3:09AM EDT until April 14 at 8:00PM EDT by NWS Miami FL

Rip Current Statement

Rip Current Statement issued April 13 at 2:00AM EDT until April 14 at 5:00AM EDT by NWS Tallahassee FL

Destination

Key West, FL

Morning in Key West on Monday

Local time

6:47 AM

EDT

Current temp

75°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

11 degrees warmer at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

6h 4m on the road

Start early — leave by 6-7 AM to arrive at a reasonable hour.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Port Saint Lucie, FL to Key West, FL covers 272.9 miles and takes about 6h 4m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.

The main roads are Overseas Highway, Florida's Turnpike, Homestead Extension of Florida's Turnpike. Expect a mix of highway and local road driving.

This is a comfortable same-day trip.

The midpoint is about 136.4 miles from Port Saint Lucie, FL. Look for rest areas, gas stations, or food options near the halfway mark.

At current regular gas prices, expect to spend about $45.59 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.

Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.

Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

This is a demanding drive. With 10 significant decision points across 272.9 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

The main spots that need attention: at 3.1 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 3.6 miles (Florida's Turnpike): Merge point - match speed before joining. Lane positioning matters here; at 99.1 miles (Homestead Extension of Florida's Turnpike): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.

Between Port Saint Lucie, FL and Key West, FL, road signs point toward Florida's Turnpike Toll South and Homestead.

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