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Trip from South Santee, SC to North Charleston, SC

Compiled and reviewed by the Trip.ovh planning team at COD Solutions Oy · Last reviewed Apr 18, 2026 · Editorial standards

Drive Time

1h 3m

Distance

46.7 mi

75 km

Drive Score

6/10

Good drive

Same Day?

Yes, doable

Fuel Cost

$7

one way

EV Charging

Unknown

Best Time to Leave

Save up to 16 min
4 AM
0h 58m ★
6 AM
1h 3m
8 AM
1h 14m
10 AM
1h 7m
12 PM
1h 6m
3 PM
1h 7m
5 PM
1h 13m
8 PM
1h 0m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Downtown South Santee, SC, SC

South Santee, SC

Hilary Halliwell

city in Berkeley, Charleston and Dorchester counties, South Carolina, United States

North Charleston, SC

Wikimedia Commons

Trip Overview

The drive from South Santee, SC to North Charleston, SC covers 46.7 miles and takes about 1h 3m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.

The route leans on US 17, Meeting Street, Carner Avenue for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 42.2 miles on US 17. At current regular gas prices, budget about $7.30 one way before food or hotel costs.

Who Is This Route For?

Weekend Trip

Doable as a same-day drive at 1h 3m. Total distance: 46.7 miles.

Family Friendly

Moderate complexity with 0 natural rest stops along the way.

Solo Traveler

1h 3m drive, comfortable solo distance.

EV Driver

0 DC fast chargers along the route. Coverage: unknown.

First-Time Driver

Mostly highway driving (90%). Straightforward navigation.

Drive Character

This is a 1h 3m highway drive covering 46.7 miles, with most of the trip on US 17 and Meeting Street. The longest continuous stretch is about 42.2 miles on US 17.

Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 8 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 17 is the longest continuous segment at about 42.2 miles.

How Hard Is This Drive?

This is a straightforward highway drive that stays mostly on US 17 and Meeting Street. Navigation is very simple - set it and forget it for most of the drive. The trickiest moment comes early in the drive near US 17.

Driving Effort 1/10

Very easy - short and simple to drive

Balances navigation complexity with total wheel time.

The drive from South Santee, SC to North Charleston, SC is easy. At 1h 3m with 90% highway, most drivers will find it relaxed and low-stress.

Where does it get tricky?

The main spots that need attention: near the start (US 17): Lane positioning matters here; at 42.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 42.6 miles (US 52 / Meeting Street): Lane positioning matters here.

Critical Maneuvers

3 of 3 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

4
0 mi into trip | ~0m in | US 17

Depart onto US 17

Lane positioning matters here

Use the straight lane.
6
42.2 mi into trip | ~56m in

Take the exit toward Meeting Street

Exit ramp - move to the correct lane early. Lane positioning matters here

Use the slight right lane. Toward Meeting Street
5
42.6 mi into trip | ~57m in | US 52 / Meeting Street

Turn right onto US 52 / Meeting Street

Lane positioning matters here

Use the straight / left / right lanes.

Main Roads

Road Distance Duration
US 17 42.2 mi 56m
Meeting Street 2.2 mi 3m
Carner Avenue 0.8 mi 1m
Meeting Street Road 0.8 mi 1m
Rivers Avenue 0.3 mi <1m
Longest stretch: US 17 — 42.2 mi, about 56m

Turn-by-Turn Driving Directions

Step-by-step road directions between South Santee, SC and North Charleston, SC.

1

Start on US 17

42 mi · 56 min · US 17
Use the straight lane.
2

Take the exit

0.4 mi · 49 sec
Toward Meeting Street Use the slight right lane.
3

Turn right onto US 52

2.2 mi · 3 min · Meeting Street
Use the straight / left / right lanes.
4

Continue on US 52

0.2 mi · 18 sec · Meeting Street Road
Use the left lane.
5

Continue on US 52

0.6 mi · 51 sec · Meeting Street Road
6

Continue on US 52

0.8 mi · 1 min · Carner Avenue
Use the straight / right lanes.
7

Continue on US 52; US 78

0.3 mi · 30 sec · Rivers Avenue
8

Arrive at destination

US 52; US 78

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 23.3 mi from South Santee, SC · 31m into the drive

city in Charleston County, South Carolina, United States

Mid-route town

Meal stop

Isle of Palms, SC

23 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Popular next leg

Isle of Palms, SC to North Charleston, SC

14.9 mi · 25m

Pacing Suggestions

Isle of Palms, SC

Fuel and coffee

A short stop after about 10 miles helps settle the day before fatigue starts building.

Isle of Palms, SC

Meal break

The midpoint is around 23.3 miles from South Santee, SC, which is a good place for a longer meal and fuel stop.

Arriving in North Charleston, SC

The final approach into North Charleston, SC usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$7.30 one way

$14.61 round trip

$3.97/gal 25.4 MPG avg 16 kg CO2
Fuel Type $/gal One Way Round Trip
midgrade $4.34 $7.98 $15.97
premium $4.70 $8.64 $17.29
diesel $5.61 $10.31 $20.62

No toll roads detected on this route.

Drive Cost (one way)

Fuel

$7

Estimated CO2 emission: 16.3 kg one way. Prices: EIA weekly data, 2026-04-13.

Driving Electric?

About $5 in charging · 0 stops · 69% less CO2

Vehicle Type kWh Stops DC Fast Home Charge
Average EV 14 0 $4.90 $2.24
Efficient EV 11.7 0 $4.09 $1.87
EV Truck/SUV 18.7 0 $6.54 $2.99

Gas CO2

16 kg

EV CO2

5 kg (69% less)

This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast as of Apr 18, 2026

Origin

South Santee, SC

Morning in South Santee on Saturday

Local time

8:42 AM

EDT

Current temp

82°F

Unavailable

Live forecast

Destination

North Charleston, SC

Morning in North Charleston on Saturday

Local time

8:42 AM

EDT

Current temp

84°F

Unavailable

Live forecast

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

2 degrees warmer at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

1h 3m on the road

Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from South Santee, SC to North Charleston, SC covers 46.7 miles and takes about 1h 3m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.

The main roads are US 17, Meeting Street, Carner Avenue. Most of the drive stays on highways, so watch for ramps and exits.

This is a comfortable same-day trip.

The midpoint is about 23.3 miles from South Santee, SC. Look for rest areas, gas stations, or food options near the halfway mark.

At current regular gas prices, expect to spend about $7.30 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.

Leave by 9 AM and you'll arrive before lunch. Even a 4 PM departure gets you there before dark in summer.

The drive from South Santee, SC to North Charleston, SC is easy. At 1h 3m with 90% highway, most drivers will find it relaxed and low-stress.

The main spots that need attention: near the start (US 17): Lane positioning matters here; at 42.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 42.6 miles (US 52 / Meeting Street): Lane positioning matters here.

The route from South Santee, SC to North Charleston, SC does not surface many named destination signs beyond the main corridor.

Yes. Nearby national parks include Fort Sumter and Fort Moultrie National Historical Park.

How this page is built

Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.

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Explore More

Return Trip

North Charleston, SC to South Santee, SC

Plan the drive back the other way.

46.8 mi 1h 4m

Explore more options from South Santee, SC or browse trips ending in North Charleston, SC.

Looking for more statewide routes? Browse SC road trips.