Origin
St. Louis, MO
Afternoon in St. Louis on Sunday
Local time
2:41 PM
CDT
Current temp
59°F
Unavailable
Sign in
No account yet?
Create accountDrive Time
2h 32m
Distance
124.8 mi
201 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$19
one way
Connecting St. Louis to Columbia, this 124.8-mile journey across Missouri is a straightforward trek that typically takes about 2 hours and 32 minutes. Since it is a relatively short trip, you can easily complete it as a one-day excursion without needing an overnight stay. You will primarily navigate via the Dwight D. Eisenhower Highway, the Avenue of the Saints, and the Daniel Boone Expressway. Budgeting roughly $19 for fuel should keep you covered for the entire distance. Because both cities are located within the Midwest, you will experience a consistent regional feel throughout your travel. This route serves as a practical link between two major Missouri hubs, making it a convenient option for travelers looking to move between the cities efficiently.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
62.4 miles from St. Louis, MO
A natural place for your longest stop of the day , about 1h 17m into the drive .
Expect a turn-heavy local drive that demands your full attention behind the wheel. While about 5% of the route consists of highway travel, the road surface and layout shift significantly as you progress. Your longest uninterrupted segment spans 80.7 miles along the Dwight D. Eisenhower Highway, providing a brief period of steady cruising. Outside of that stretch, the drive feels less like a monotonous interstate haul and more like a technical, engaging navigation through the local landscape. Be prepared for a dynamic experience where the road demands active steering rather than passive highway driving.
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. There are only a few real navigation decisions along the way. The trickiest moment comes early in the drive near Market Street.
Easy - simple navigation with a manageable amount of wheel time
This is a straightforward 2h 32m drive. You will face about 6 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
The main spots that need attention: near the start (Market Street): Lane positioning matters here; at 1.6 miles: Multiple destination signs - pick the right one; at 1.9 miles (I 64; US 40 / Jack Buck Memorial Highway): Merge point - match speed before joining. Lane positioning matters here.
These are the spots where you need to pay the most attention. Preview them before you drive.
Depart onto Market Street
Lane positioning matters here
Take the ramp toward I 64 West, US 40 West: Wentzville
Multiple destination signs - pick the right one
Merge onto I 64; US 40 / Jack Buck Memorial Highway
Merge point - match speed before joining. Lane positioning matters here
Take the exit onto US 40 toward I 70 West, US 40 West: Kansas City
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Take the exit toward MO 163: Downtown
Exit ramp - move to the correct lane early
| Road | Distance | Duration |
|---|---|---|
| Dwight D Eisenhower Highway | 80.7 mi | 1h 35m |
| Avenue of the Saints | 27.8 mi | 33m |
| Daniel Boone Expressway | 5.7 mi | 7m |
| Jack Buck Memorial Highway | 4.3 mi | 5m |
| Sheriff Roger I. Wilson Memorial Highway | 2 mi | 2m |
| Market Street | 1.6 mi | 3m |
| North Providence Road | 1.2 mi | 2m |
| US 40 | 0.6 mi | 1m |
Step-by-step road directions between St. Louis, MO and Columbia, MO.
Start on Market Street
Take the ramp
Merge onto I 64; US 40
Continue on I 64; US 40
Continue on I 64; US 40; US 61
Take the exit onto US 40
Merge onto I 70; US 40
Continue on I 70; US 40
Continue on I 70; US 40
Take the exit
Turn left onto MO 163
Arrive at destination
For the best experience, plan for a single stop to break up the 2-hour and 32-minute drive. Since the total mileage is just under 125 miles, you have plenty of flexibility to adjust your departure time based on your personal schedule. Keep in mind that the turn-heavy nature of the route means you should stay alert, especially when transitioning between the various expressways and local roads. Setting aside $19 for fuel is a safe estimate, but it is always wise to keep an eye on your gauge during the longer 80.7-mile stretch on the Eisenhower Highway. Taking advantage of the route's brevity allows you to spend more time at your destination rather than worrying about a complex travel itinerary.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 37m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 62.4 miles or 1h 17m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 4m
Traffic, exits, and arrival timing usually matter more near Columbia, MO than in the middle of the route.
Open the route before leaving St. Louis, MO so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from St. Louis, MO
This is one driving day of about 124.8 miles and 2h 32m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 62.4 mi from St. Louis, MO · 1h 17m into the drive
Mid-route town
Meal stop
62 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 80 miles helps settle the day before fatigue starts building.
The midpoint is around 62.4 miles from St. Louis, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before Dwight D Eisenhower Highway if your tank is already low. That segment runs about 80.7 miles.
The final approach into Columbia, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Columbia, MO.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$18.96 one way
$37.91 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.25 | $20.90 | $41.79 |
| premium | $4.80 | $23.56 | $47.12 |
| diesel | $5.64 | $27.73 | $55.45 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$19
Meals
$25–$50
Total
$44–$69
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 43.7 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $13 in charging · 0 stops · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 37.4 | 0 | $13.10 | $5.99 |
| Efficient EV | 31.2 | 0 | $10.92 | $4.99 |
| EV Truck/SUV | 49.9 | 0 | $17.47 | $7.99 |
Gas CO2
44 kg
EV CO2
15 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Current conditions at both ends of the drive.
Origin
Afternoon in St. Louis on Sunday
Local time
2:41 PM
CDT
Current temp
59°F
Unavailable
Destination
Afternoon in Columbia on Sunday
Local time
2:41 PM
CDT
Current temp
50°F
Unavailable
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Thanks for your feedback!
Your tip has been submitted. Thanks!
/500
Recent Tips
·
Explore more options from St. Louis, MO or browse trips ending in Columbia, MO.
Looking for more statewide routes? Browse MO road trips.
Explore maps for St. Louis, MO or Columbia, MO on MapSof.net.