Drive Time
4h 32m
Distance
222.4 mi
358 km
Drive Score
10/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$34
one way
Photo: Valeria Boltneva
The drive from Unionville, MO to O'Fallon, MO covers 222.4 miles and takes about 4h 32m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Avenue of the Saints, US 63, Chicago-Kansas City Expressway for much of the mileage, and the overall profile is mixed drive. The longest uninterrupted segment is about 73.7 miles on Avenue of the Saints. At current regular gas prices, budget about $33.78 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
111.2 miles from Unionville, MO
A natural place for your longest stop of the day , about 2h 18m into the drive .
The drive from Unionville, MO to O'Fallon, MO covers 222.4 miles and takes about 4h 32m, using a mix of highways and local roads.
Mostly flat terrain
Total Climb
483 ft
Total Descent
999 ft
Highest Point
1,062 ft
Elevation Range
580 ft
This route mixes highway mileage with some local-road sections near the start or finish. You will hit about 14 points where you need to pay attention to lane position or signs. The trickiest moment comes around 24.5 miles in near US 63.
Moderate - straightforward overall, but long enough or busy enough to require pacing
This drive requires moderate attention. Across 222.4 miles you will encounter 14 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 24.5 miles (US 63): Navigation decision point; at 78.9 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 214.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
These are the spots where you need to pay the most attention. Preview them before you drive.
At end of road, turn right onto US 63
Navigation decision point
Take the exit toward US 36 East, MO 110 East: Hannibal
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Take the exit toward I 70 East: Saint Louis
Exit ramp - move to the correct lane early. Lane positioning matters here
Take the exit toward MO K: O'Fallon
Exit ramp - move to the correct lane early. Lane positioning matters here
Keep slight right at fork onto Drennen Parkway toward MO K: O'Fallon
Highway fork - watch signs carefully
| Road | Distance | Duration |
|---|---|---|
| Avenue of the Saints | 73.7 mi | 1h 27m |
| US 63 | 54.5 mi | 1h 4m |
| Chicago-Kansas City Expressway | 52.9 mi | 1h 1m |
| Main Street | 24.5 mi | 36m |
| Dwight D Eisenhower Highway | 6.4 mi | 7m |
| V.F.W. Memorial Highway | 5.8 mi | 6m |
| Veterans Road | 2.1 mi | 3m |
| South Main Street | 0.6 mi | 1m |
Step-by-step road directions between Unionville, MO and O'Fallon, MO.
Start on US 136
At end of road, turn right onto US 63
Take the exit
Merge onto US 36; MO 110
Continue on US 24; US 36; MO 110
Take the exit
Turn right onto Veterans Road
At end of road, turn left onto County Road 422
Continue on Paris Gravel Road
Take the ramp
Merge onto US 61
Take the exit
Merge onto I 70
Take the exit
Turn straight onto Drennen Parkway
Keep slight right at fork onto Drennen Parkway
Turn slight left
Continue on South Main Street
Turn right
Arrive at destination
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 42m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 111.2 miles or 2h 18m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 43m
Traffic, exits, and arrival timing usually matter more near O'Fallon, MO than in the middle of the route.
Open the route before leaving Unionville, MO so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Unionville, MO
This is one driving day of about 222.4 miles and 4h 32m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 111.2 mi from Unionville, MO · 2h 18m into the drive
Mid-route town
Meal stop
111 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 80 miles helps settle the day before fatigue starts building.
The midpoint is around 111.2 miles from Unionville, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before Avenue of the Saints if your tank is already low. That segment runs about 73.7 miles.
The final approach into O'Fallon, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around O'Fallon, MO.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$33.78 one way
$67.56 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.25 | $37.24 | $74.48 |
| premium | $4.80 | $41.98 | $83.97 |
| diesel | $5.64 | $49.41 | $98.82 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$34
Meals
$25–$50
Total
$59–$84
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 77.8 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $23 in charging · 0 stops · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 66.7 | 0 | $23.35 | $10.68 |
| Efficient EV | 55.6 | 0 | $19.46 | $8.90 |
| EV Truck/SUV | 89 | 1 | $31.14 | $14.23 |
Gas CO2
78 kg
EV CO2
26 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive. If you're planning ahead, check the forecast closer to your travel date.
Origin
Afternoon in Unionville on Saturday
Local time
4:19 PM
CDT
Current temp
79°F
Forecast unavailable right now
Destination
Afternoon in O'Fallon on Saturday
Local time
4:19 PM
CDT
Current temp
53°F
Forecast unavailable right now
Along the Route
55°F
Quincy, IL
111 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
An early start around 7-8 AM gets you there with plenty of daylight left.
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