This 273.5-mile drive from Warm Mineral Springs, FL to Jacksonville, FL is a manageable one-day trip, estimated to take about 5 hours and 20 minutes. The route is primarily highway-focused, with 95% of it on major roads like I-75, US 301, and I-10, making for a relatively straightforward journey. With a fuel cost estimated at $44, it's an economical option for exploring within the state of Florida. You'll encounter one longest stretch of 165.2 miles on I-75, so plan your stops accordingly. This drive is best suited for those who prefer efficient travel over leisurely sightseeing.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
136.8 miles from Warm Mineral Springs, FL
A natural place for your longest stop of the day
, about 2h 33m into the drive
.
Main Roads
Road
Distance
Duration
I 75
165.2 mi
2h 57m
US 301
75.9 mi
1h 34m
I 10
16.8 mi
19m
North River Road
5.7 mi
9m
Tamiami Trail South
1.6 mi
2m
Northwest 70th Street
1.5 mi
2m
De Leon Drive
1.3 mi
3m
FL 326
1.1 mi
1m
Longest stretch:
I 75
— 165.2 mi, about 2h 57m
Turn-by-Turn Driving Directions
Step-by-step road directions between Warm Mineral Springs, FL and Jacksonville, FL.
1
Start on San Servando Avenue
504 ft·24 sec·San Servando Avenue
2
At end of road, turn right onto Ortiz Boulevard
480 ft·15 sec·Ortiz Boulevard
3
Turn left onto De Leon Drive
1.3 mi·3 min·De Leon Drive
4
Turn right onto US 41
1.6 mi·2 min·Tamiami Trail South
5
Turn right onto FL 777
5.7 mi·9 min·North River Road
6
Turn left
0.4 mi·49 sec
Toward I 75 North: Tampa
7
Merge onto I 75
165 mi·2 hr 57 min·I 75
Use the straight / slight right lanes.
8
Take the exit
0.2 mi·32 sec
Exit 358Toward FL 326Use the straight / slight right lanes.
9
Turn slight right
144 ft·4 sec
10
Turn slight right onto FL 326
1.1 mi·1 min·FL 326
Use the straight / right lanes.
11
Continue on FL 326
1.5 mi·2 min·Northwest 70th Street
12
Turn left onto US 301; US 441
5.5 mi·6 min·US 301; US 441
Use the left lane.
13
Turn straight onto US 301
52 mi·1 hr 5 min·US 301
Toward North US 301: StarkeUse the straight lane.
14
Continue on US 301
18 mi·22 min·US 301
15
Take the exit
0.9 mi·1 min
Toward I 10 East: Jacksonville
16
Merge onto I 10
17 mi·19 min·I 10
Use the straight / slight right lanes.
17
Take the exit
0.4 mi·33 sec
Toward I 95 South: Jacksonville Beaches, Daytona Beach
18
Keep slight left at fork
0.7 mi·56 sec
Toward I 95 North: International Airport, SavannahUse the slight left / slight right lanes.
19
Merge onto I 95
0.7 mi·1 min·I 95
20
Take the exit onto US 17; FL 228
0.2 mi·26 sec·US 17; FL 228
Exit 353BToward Union Street, Beaver Street
21
Turn straight onto US 17; US 23; FL 228
0.7 mi·1 min·Union Street
Use the straight / left lanes.
22
Arrive at destination
US 17
Trip Plan
Given the 5-hour and 20-minute duration, this 273.5-mile trip is easily doable in a single day. To make the most of your drive, consider an early morning departure to avoid any potential traffic, especially as you approach Jacksonville. You'll have one longest stretch of 165.2 miles on I-75, so ensure you have ample fuel before embarking on this segment. The estimated fuel cost is $44, which is quite reasonable. Plan for at least one stop to stretch your legs and refuel, perhaps midway through your journey, to break up the drive.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 136.8 miles from Warm Mineral Springs, FL, or about 2h 33m into the drive.
The longest continuous stretch on this route runs about 165.2 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 60 miles or 1h 11m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 136.8 miles or 2h 33m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 17m
Traffic, exits, and arrival timing usually matter more near Jacksonville, FL than in the middle of the route.
Before You Leave
+
Open the route before leaving Warm Mineral Springs, FL so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Warm Mineral Springs, FL
This is one driving day of about 273.5 miles and 5h 20m.
Your first comfortable stop window is around 60 miles from Warm Mineral Springs, FL.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 75 for about 165.2 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 17
5 decision points cluster between mile 0.1 and 272.6 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
0.1 mi into trip|~0m in|Ortiz Boulevard
At end of road, turn right onto Ortiz Boulevard
Complex interchange - multiple decisions in a short stretch
5
9.1 mi into trip|~16m in|I 75
Merge onto I 75
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
7
174.4 mi into trip|~3h 14m in
Take the exit toward FL 326
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Exit 358
Toward FL 326
8
271.2 mi into trip|~5h 15m in
Keep slight left at fork toward I 95 North: International Airport, Savannah
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 95 North: International Airport, Savan...
6
272.6 mi into trip|~5h 17m in|US 17; FL 228
Take the exit onto US 17; FL 228 toward Union Street, Beaver Street
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 353B
Toward Union Street, Beaver Street
Fuel & Cost
Regular Gas
$43.53 one way
$87.07 round trip
$4.04/gal25.4 MPG avg96 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.40
$47.36
$94.71
premium
$4.72
$50.86
$101.71
diesel
$5.61
$60.39
$120.77
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$44
Meals
$25–$50
Total
$69–$94
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 95.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $29 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
82.1
1
$28.72
$13.13
Efficient EV
68.4
0
$23.93
$10.94
EV Truck/SUV
109.4
1
$38.29
$17.50
Gas CO2
96 kg
EV CO2
32 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Warm Mineral Springs, FL
Afternoon
in Warm Mineral Springs on Saturday
Local time
4:43 PM
EDT
Current temp
64°F
Unavailable
Live forecast
Destination
Jacksonville, FL
Afternoon
in Jacksonville on Saturday
Local time
4:43 PM
EDT
Current temp
60°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
4 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 20m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
De Soto National Memorial
National Memorial
In May 1539, Conquistador Hernando de Soto’s army of soldiers, hired mercenaries, craftsmen, and clergy made landfall in Tampa Bay. They were met with fierce resistance of indigenous people protecting...
10 mi from route
~25 min detour
Free
near mile 47.2
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a highway-focused drive for the majority of this 273.5-mile trip. With 95% of the route utilizing major interstates and highways, including a significant 165.2-mile segment on I-75, the pace is generally brisk. You'll likely experience a consistent driving rhythm for much of the 5-hour and 20-minute journey. While not a winding scenic byway, this route prioritizes direct travel, making it efficient for covering ground quickly. The profile suggests a straightforward, almost utilitarian approach to getting from point A to point B within Florida.
95% highway — fuel and pacing are the main things to plan.
22 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 165.2 mi on I 75.
How Hard Is This Drive?
7/10
This is a straightforward highway drive that stays mostly on I 75 and US 301. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.1 miles in near Ortiz Boulevard.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 17 significant decision points across 273.5 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.1 miles (Ortiz Boulevard): Complex interchange - multiple decisions in a short stretch; at 9.1 miles (I 75): Merge point - match speed before joining. Lane positioning matters here; at 174.4 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Jacksonville occupies one of the most coveted spots on the Atlantic coast. Set amongst abundant beaches and possessing an ideal subtropical climate, its crown jewel is the unique habitat and natural beauty of the St. Johns River. For this reason and more, "The River City" is a popular destination for vacationers looking for a laid-back Sunshine State escape.
Doable as a same-day drive at 5h 20m. Total distance: 273.5 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 20m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (95%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 165.2 miles on I 75. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Jacksonville, FL before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 0.1 miles (Ortiz Boulevard): Complex interchange - multiple decisions in a short stretch; at 9.1 miles (I 75): Merge point - match speed before joining. Lane positioning matters here; at 174.4 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Yes — De Soto National Memorial. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.3 hours each way, a round trip means 10.7 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Jacksonville, FL before the return drive.
