The drive from Webb City, MO to Saint Charles, MO covers 288.9 miles and takes about 5h 22m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Congressman Gene Taylor Highway, I 270, Governor Warren E Hearnes Memorial Highway for much of the mileage,
and the overall profile is turn-heavy local drive.
The longest uninterrupted segment is about 260.4 miles on Congressman Gene Taylor Highway.
At current regular gas prices, budget about $45.17 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
144.4 miles from Webb City, MO
A natural place for your longest stop of the day
, about 2h 39m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 22m. Total distance: 288.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 22m drive, comfortable solo distance.
Scenic Drive
Turn-heavy local drive route profile with national parks nearby.
Drive Character
Expect a 5h 22m drive with frequent turns across 288.9 miles of local and secondary roads.
This route has more turning and local-road decision points than a simple highway run.
There are about 25 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Congressman Gene Taylor Highway is the longest continuous segment at about 260.4 miles.
How Hard Is This Drive?
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 269.4 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 18 significant decision points across 288.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 269.4 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 269.6 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 282.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 18 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
8
269.4 mi into trip|~4h 55m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 276
Toward I 270: Chicago, Memphis
8
269.6 mi into trip|~4h 56m in
Keep slight left at fork toward I 270 North: Chicago
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left lane.
Toward I 270 North: Chicago
8
282.8 mi into trip|~5h 12m in
Take the exit toward I 70: Kansas City, Saint Louis, Saint Louis Lambert International Airport
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 20A
Toward I 70: Kansas City, Saint Louis, Saint Lo...
7
283.8 mi into trip|~5h 14m in
Keep slight left at fork toward I 70 West: Kansas City
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left lane.
Toward I 70 West: Kansas City
9
287.4 mi into trip|~5h 19m in
Keep slight right at fork toward I 70 Business: Fifth Street North, Bass Pro Drive, Ameristar Boulevard
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the right lane.
Toward I 70 Business: Fifth Street North, Bass...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Webb City, MO to Saint Charles, MO, road signs begin pointing toward Memphis along the way.
Memphis
269.4 mi in|~4h 55m
Main Roads
Road
Distance
Duration
Congressman Gene Taylor Highway
260.4 mi
4h 42m
I 270
12.6 mi
15m
Governor Warren E Hearnes Memorial Highway
3.4 mi
3m
I 70
2.7 mi
3m
East 7th Street
2 mi
3m
South Fifth Street
1 mi
2m
Cimarron Road
0.9 mi
1m
I 49 Business
0.6 mi
<1m
Longest stretch:
Congressman Gene Taylor Highway
— 260.4 mi, about 4h 42m
Turn-by-Turn Driving Directions
Step-by-step road directions between Webb City, MO and Saint Charles, MO.
1
Start on MO D
0.4 mi·38 sec·North Main Street
2
Turn left onto I 49 Business; MO 171
0.3 mi·39 sec·East MacArthur Drive
3
Enter roundabout onto I 49 Business; MO 171
234 ft·3 sec·I 49 Business; MO 171
4
Continue on I 49 Business; MO 171
0.6 mi·37 sec·I 49 Business; MO 171
5
Take the exit
0.6 mi·41 sec
Toward MO 249 South: Joplin
6
Merge onto MO 249
3.4 mi·3 min·Governor Warren E Hearnes Memorial Highway
Toward MO 249 South: Joplin
7
Take the exit
0.3 mi·38 sec
Toward MO 66, I 44 Business
8
Turn left onto I 44 Business; MO 66
2.0 mi·3 min·East 7th Street
9
Continue on I 44 Business; MO 66
0.9 mi·1 min·Cimarron Road
10
Take the ramp onto I 44 Business
0.6 mi·1 min·I 44 Business
Toward I 44 East, I 49 North, US 71 North: Springfield, Kansas City
11
Merge onto I 44; I 49; US 71
260 mi·4 hr 42 min·Congressman Gene Taylor Highway
Use the straight / slight right lanes.
12
Take the exit
0.2 mi·18 sec
Exit 276Toward I 270: Chicago, MemphisUse the slight right lane.
13
Keep slight left at fork
0.1 mi·11 sec
Toward I 270 North: ChicagoUse the slight left lane.
14
Continue on this road
0.5 mi·52 sec·this road
Exit 276Toward I 270 North: Chicago
15
Merge onto I 270
13 mi·15 min·I 270
Use the straight lane.
16
Take the exit
1.0 mi·1 min
Exit 20AToward I 70: Kansas City, Saint Louis, Saint Louis Lambert International AirportUse the slight right lane.
17
Keep slight left at fork
0.1 mi·11 sec
Toward I 70 West: Kansas CityUse the slight left lane.
18
Continue on this road
0.6 mi·57 sec·this road
Exit 20BToward I 70 West: Kansas City
19
Merge onto I 70
2.7 mi·3 min·I 70
20
Take the exit onto I 70 Business
0.2 mi·17 sec·I 70 Business
Exit 229BToward I 70 Business: Fifth StreetUse the straight / slight right lanes.
21
Keep slight right at fork
231 ft·5 sec
Toward I 70 Business: Fifth Street North, Bass Pro Drive, Ameristar BoulevardUse the right lane.
22
Turn slight right onto I 70 Business
1.0 mi·2 min·South Fifth Street
Use the right lane.
23
Turn right onto Jefferson Street
0.2 mi·44 sec·Jefferson Street
24
Turn left onto North Second Street
0.2 mi·34 sec·North Second Street
25
Arrive at destination
North Second Street
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 144.4 miles from Webb City, MO, or about 2h 39m into the drive.
The longest continuous stretch on this route runs about 260.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 64 miles or 1h 12m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 144.4 miles or 2h 39m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 20m
Traffic, exits, and arrival timing usually matter more near Saint Charles, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Webb City, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Webb City, MO
This is one driving day of about 288.9 miles and 5h 22m.
Your first comfortable stop window is around 64 miles from Webb City, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Congressman Gene Taylor Highway for about 260.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 144.4 mi from Webb City, MO
· 2h 39m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
George Washington Carver National Monument
National Monument
The young child known as the "Plant Doctor" tended his secret garden while observing the day-to-day operations of a 19th century farm. Nature and nurture ultimately influenced George on his quest for...
Wilson's Creek was the first major Civil War battle fought west of the Mississippi River, and where the first Union general was killed in action. The costly Southern victory on August 10, 1861, focuse...
7 mi from route
~19 min detour
Free
near mile 59.8
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
14 mi from route
~36 min detour
$19
near mile 278.9
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $30 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
86.7
1
$30.33
$13.87
Efficient EV
72.2
0
$25.28
$11.56
EV Truck/SUV
115.6
1
$40.45
$18.49
Gas CO2
101 kg
EV CO2
34 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Webb City, MO
Late night
in Webb City on Saturday
Local time
3:11 AM
CDT
Current temp
57°F
Unavailable
Live forecast
Destination
Saint Charles, MO
Late night
in Saint Charles on Saturday
Local time
3:11 AM
CDT
Current temp
57°F
Unavailable
Live forecast
76°F
Waynesville, MO
144 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
5h 22m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Webb City, MO to Saint Charles, MO covers 288.9 miles and takes about 5h 22m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Congressman Gene Taylor Highway, I 270, Governor Warren E Hearnes Memorial Highway. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 144.4 miles from Webb City, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $45.17 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 18 significant decision points across 288.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 269.4 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 269.6 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 282.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
On the drive from Webb City, MO to Saint Charles, MO, road signs begin pointing toward Memphis along the way.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, NREL for EV charging, and NPS for national parks. See our methodology for refresh cadence and limitations.
