The drive from Amory, MS to Oxford, MS covers 280.1 miles and takes about 5h 57m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on MS 25, I 55, US 84 for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 152.2 miles on MS 25.
At current regular gas prices, budget about $42.30 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
140.1 miles from Amory, MS
A natural place for your longest stop of the day
, about 2h 58m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 57m. Total distance: 280.1 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 57m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (94%). Some complex stretches to watch for.
Drive Character
This is a 5h 57m highway drive covering 280.1 miles, with most of the trip on MS 25 and I 55. The longest continuous stretch is about 152.2 miles on MS 25.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 27 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
MS 25 is the longest continuous segment at about 152.2 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on MS 25 and I 55. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.4 miles in near US 278 / 6th Avenue South.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 22 significant decision points across 280.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.4 miles (US 278 / 6th Avenue South): Lane positioning matters here; at 0.7 miles (Highway 125): Lane positioning matters here; at 12.4 miles (MS 8; MS 25): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 22 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
6
0.4 mi into trip|~0m in|US 278 / 6th Avenue South
Turn right onto US 278 / 6th Avenue South
Lane positioning matters here
Use the straight / right lanes.
5
0.7 mi into trip|~1m in|Highway 125
Turn left onto Highway 125
Lane positioning matters here
Use the left lane.
8
12.4 mi into trip|~20m in|MS 8; MS 25
Keep slight right at fork onto MS 8; MS 25 toward US 45 North, MS 25 South, MS 8 West: Tupelo, Aberdeen
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / right lanes.
Toward US 45 North, MS 25 South, MS 8 West: Tup...
6
184.5 mi into trip|~3h 50m in|I 55
Keep slight left at fork onto I 55 toward I 55 South: McComb, New Orleans
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 55 South: McComb, New Orleans
7
238.6 mi into trip|~4h 48m in
Keep slight right at fork toward US 84: South Brookhaven, Natchez
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 84: South Brookhaven, Natchez
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Amory, MS and Oxford, MS, road signs point toward New Orleans and Natchez.
New Orleans
184.5 mi in|~3h 50m|via I 55
Natchez
238.3 mi in|~4h 48m
Main Roads
Road
Distance
Duration
MS 25
152.2 mi
3h 3m
I 55
59.9 mi
1h 5m
US 84
22.7 mi
26m
US Highway 45 Alternate
15.5 mi
20m
Gloster Road
6.5 mi
15m
Oxford-Meadville Road
6.3 mi
15m
Highway 125
5.2 mi
9m
MS 8
4.6 mi
7m
Longest stretch:
MS 25
— 152.2 mi, about 3h 3m
Turn-by-Turn Driving Directions
Step-by-step road directions between Amory, MS and Oxford, MS.
1
Start on 2nd Avenue South
47 ft·7 sec·2nd Avenue South
2
Turn left onto MS 25
0.4 mi·42 sec·South Main Street
3
Turn right onto US 278
0.4 mi·52 sec·6th Avenue South
Use the straight / right lanes.
4
Turn left onto Highway 125
5.2 mi·9 min·Highway 125
Use the left lane.
5
At end of road, turn right onto MS 25
6.5 mi·9 min·MS 25
6
Keep slight right at fork onto MS 8; MS 25
4.6 mi·7 min·MS 8; MS 25
Toward US 45 North, MS 25 South, MS 8 West: Tupelo, AberdeenUse the straight / right lanes.
7
Turn left onto MS 25
8.9 mi·15 min·MS 25
Use the left lane.
8
Take the ramp onto MS 25
0.7 mi·1 min·MS 25
Toward US 45 Alternate South, MS 25 South: West Point
9
Merge onto US 45 ALT; MS 25
15 mi·20 min·US Highway 45 Alternate
Use the straight lane.
10
Take the exit onto MS 25
12 mi·13 min·MS 25
Toward US 82 West, MS 12 West, MS 25 South: Starkville
11
Take the exit onto MS 25
5.0 mi·6 min·MS 25
Toward MS 25 South: Louisville
12
Continue on MS 25
1.9 mi·2 min·MS 25
Use the left lane.
13
Keep slight right at fork onto MS 25
25 mi·28 min·MS 25
14
Take the exit onto MS 25
93 mi·1 hr 46 min·MS 25
15
Take the exit
0.2 mi·26 sec
16
Merge onto I 55
6.1 mi·7 min·I 55
17
Keep slight left at fork onto I 55
54 mi·57 min·I 55
Toward I 55 South: McComb, New Orleans
18
Take the exit
0.3 mi·35 sec
Toward US 84: South Brookhaven, Natchez
19
Keep slight right at fork
409 ft·9 sec
Toward US 84: South Brookhaven, Natchez
20
Merge onto US 84
23 mi·26 min·US 84
21
Turn left onto MS 184
1.4 mi·2 min·MS 184
22
Turn left onto US 98
1.9 mi·2 min·US 98
23
Turn right onto Yap 3 Road
2.6 mi·6 min·Yap 3 Road
24
Continue on Gloster Road
3.8 mi·9 min·Gloster Road
25
At end of road, turn right onto Gloster Road
2.8 mi·6 min·Gloster Road
26
Continue on Oxford-Meadville Road
6.3 mi·15 min·Oxford-Meadville Road
27
Arrive at destination
Oxford-Meadville Road
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 140.1 miles from Amory, MS, or about 2h 58m into the drive.
The longest continuous stretch on this route runs about 152.2 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 62 miles or 1h 28m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 140.1 miles or 2h 58m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 38m
Traffic, exits, and arrival timing usually matter more near Oxford, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Amory, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Amory, MS
This is one driving day of about 280.1 miles and 5h 57m.
Your first comfortable stop window is around 62 miles from Amory, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on MS 25 for about 152.2 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 140.1 mi from Amory, MS
· 2h 58m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
5 mi from route
~12 min detour
Free
near mile 183.5
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
Discover the history of all the peoples of Natchez, Mississippi, from European settlement, African enslavement, the American cotton economy, to the Civil Rights struggle on the lower Mississippi River...
30 mi from route
~74 min detour
Free
near mile 270.4
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$42.30 one way
$84.60 round trip
$3.84/gal25.4 MPG avg98 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$46.44
$92.87
premium
$4.56
$50.27
$100.55
diesel
$5.61
$61.84
$123.69
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$42
Meals
$25–$50
Total
$67–$92
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 98 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
2 DC fast chargers
· Coverage: fair
ChargePoint Charging Station
Starkville, Mississippi
ChargePoint
1 DCFC
ChargePoint Charging Station
Amory, Mississippi
ChargePoint
1 DCFC
ChargePoint: 2
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $29 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
84
1
$29.41
$13.44
Efficient EV
70
0
$24.51
$11.20
EV Truck/SUV
112
1
$39.21
$17.93
Gas CO2
98 kg
EV CO2
33 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Amory, MS
Evening
in Amory on Thursday
Local time
7:10 PM
CDT
Current temp
53°F
Unavailable
Live forecast
Destination
Oxford, MS
Evening
in Oxford on Thursday
Local time
7:10 PM
CDT
Current temp
80°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
27 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 57m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Amory, MS to Oxford, MS covers 280.1 miles and takes about 5h 57m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are MS 25, I 55, US 84. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 140.1 miles from Amory, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $42.30 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 22 significant decision points across 280.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 0.4 miles (US 278 / 6th Avenue South): Lane positioning matters here; at 0.7 miles (Highway 125): Lane positioning matters here; at 12.4 miles (MS 8; MS 25): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Amory, MS and Oxford, MS, road signs point toward New Orleans and Natchez.
