The drive from Amory, MS to Biloxi, MS covers 291.9 miles and takes about 5h 46m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on US 45, I 59, US 49 for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 106.4 miles on US 45.
At current regular gas prices, budget about $44.08 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
146 miles from Amory, MS
A natural place for your longest stop of the day
, about 2h 57m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 46m. Total distance: 291.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 46m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (97%). Some complex stretches to watch for.
Drive Character
This is a 5h 46m highway drive covering 291.9 miles, with most of the trip on US 45 and I 59. The longest continuous stretch is about 106.4 miles on US 45.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 39 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 45 is the longest continuous segment at about 106.4 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on US 45 and I 59. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 40.4 miles in near US 45.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 22 significant decision points across 291.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 40.4 miles (US 45): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 131.8 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 220.5 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 22 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
7
40.4 mi into trip|~56m in|US 45
Keep slight left at fork onto US 45 toward US 45 South: Macon, Meridian
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 45 South: Macon, Meridian
8
131.8 mi into trip|~2h 42m in|I 59
Keep slight left at fork onto I 59 toward I 59 South: Laurel, New Orleans
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 59 South: Laurel, New Orleans
7
220.5 mi into trip|~4h 18m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
223.7 mi into trip|~4h 22m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
224 mi into trip|~4h 23m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Amory, MS and Biloxi, MS, road signs point toward Meridian, New Orleans, Mobile, Gulfport, Mississippi Gulf Coast and Multi Purpose Center - among others.
Meridian
40.2 mi in|~55m|via US 45
New Orleans
131.8 mi in|~2h 42m|via I 59
Mobile
220.5 mi in|~4h 18m|via US 98
Gulfport
223.7 mi in|~4h 22m
Mississippi Gulf Coast
223.7 mi in|~4h 22m
Multi Purpose Center
224 mi in|~4h 23m
Hattiesburg
224 mi in|~4h 23m
Main Roads
Road
Distance
Duration
US 45
106.4 mi
2h 5m
I 59
88.7 mi
1h 36m
US 49
41.9 mi
49m
Biloxi-D'Iberville Scenic Expressway
20.5 mi
24m
I 20
8.1 mi
9m
MS 25
6.5 mi
9m
Highway 125
5.2 mi
9m
US 98
3.2 mi
4m
Longest stretch:
US 45
— 106.4 mi, about 2h 5m
Turn-by-Turn Driving Directions
Step-by-step road directions between Amory, MS and Biloxi, MS.
1
Start on 2nd Avenue South
47 ft·7 sec·2nd Avenue South
2
Turn left onto MS 25
0.4 mi·42 sec·South Main Street
3
Turn right onto US 278
0.4 mi·52 sec·6th Avenue South
Use the straight / right lanes.
4
Turn left onto Highway 125
5.2 mi·9 min·Highway 125
Use the left lane.
5
At end of road, turn right onto MS 25
6.5 mi·9 min·MS 25
6
Keep slight left at fork
0.7 mi·1 min
Toward US 45 South: Columbus
7
Merge onto US 45
0.6 mi·44 sec·US 45
8
Continue on US 45
0.8 mi·52 sec·US 45
9
Continue on US 45
2.2 mi·2 min·US 45
10
Continue on US 45
2.6 mi·3 min·US 45
11
Continue on US 45
3.9 mi·4 min·US 45
12
Continue on US 45
0.6 mi·44 sec·US 45
13
Continue on US 45
1.9 mi·2 min·US 45
14
Continue on US 45
0.4 mi·27 sec·US 45
15
Continue on US 45
1.8 mi·2 min·US 45
16
Continue on US 45
7.8 mi·10 min·US 45
17
Continue on US 45; MS 50
0.8 mi·1 min·US 45; MS 50
Use the left lane.
18
Take the exit
3.7 mi·4 min
19
Take the exit onto US 45
0.2 mi·43 sec·US 45
Toward US 45 South: Macon, Meridian
20
Keep slight left at fork onto US 45
135 ft·7 sec·US 45
Toward US 45 South: Macon, Meridian
21
Turn left onto US 45
15 mi·16 min·US 45
Use the left / straight lanes.
22
Continue on US 45
64 mi·1 hr 13 min·US 45
23
Keep slight right at fork onto US 45
3.9 mi·4 min·US 45
24
Take the exit
0.5 mi·1 min
Toward I 59 South, I 20 West: Meridian
25
Merge onto I 20; I 59
6.3 mi·7 min·I 20; I 59
Use the straight / slight right lanes.
26
Continue on I 20; I 59; US 80
1.8 mi·2 min·I 20; I 59; US 80
Use the straight lane.
27
Keep slight left at fork onto I 59
89 mi·1 hr 36 min·I 59
Toward I 59 South: Laurel, New OrleansUse the slight left / slight right lanes.
28
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
29
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
30
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
31
Turn right onto US 49
42 mi·49 min·US 49
Use the straight lane.
32
Take the exit
0.8 mi·1 min
Toward MS 67 South: D'Iberville, Biloxi
33
Continue on MS 67
20 mi·24 min·Biloxi-D'Iberville Scenic Expressway
34
Continue on I 110
3.2 mi·4 min·I 110
35
Take the exit
0.4 mi·47 sec
Exit 1cToward Division Street
36
Turn left onto Division Street
0.6 mi·1 min·Division Street
37
Turn right onto Main Street
0.5 mi·1 min·Main Street
38
Turn left onto Howard Avenue
91 ft·3 sec·Howard Avenue
39
Arrive at destination
Howard Avenue
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 146 miles from Amory, MS, or about 2h 57m into the drive.
The longest continuous stretch on this route runs about 106.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 64 miles or 1h 24m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 146 miles or 2h 57m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 41m
Traffic, exits, and arrival timing usually matter more near Biloxi, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Amory, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Amory, MS
This is one driving day of about 291.9 miles and 5h 46m.
Your first comfortable stop window is around 64 miles from Amory, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 45 for about 106.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 146 mi from Amory, MS
· 2h 57m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Tupelo National Battlefield
National Battlefield
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $31 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
87.6
1
$30.65
$14.01
Efficient EV
73
0
$25.54
$11.68
EV Truck/SUV
116.8
1
$40.87
$18.68
Gas CO2
102 kg
EV CO2
34 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Amory, MS
Evening
in Amory on Thursday
Local time
8:10 PM
CDT
Current temp
53°F
Unavailable
Live forecast
Destination
Biloxi, MS
Evening
in Biloxi on Thursday
Local time
8:10 PM
CDT
Current temp
61°F
Unavailable
Live forecast
79°F
Meridian, MS
146 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
8 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 46m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Amory, MS to Biloxi, MS covers 291.9 miles and takes about 5h 46m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 45, I 59, US 49. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 146 miles from Amory, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $44.08 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 22 significant decision points across 291.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 40.4 miles (US 45): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 131.8 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 220.5 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Amory, MS and Biloxi, MS, road signs point toward Meridian, New Orleans, Mobile, Gulfport, Mississippi Gulf Coast and Multi Purpose Center - among others.
