This 363-mile drive from Anna, Texas, to Amarillo, Texas, will take approximately 6 hours and 39 minutes to complete. It's a straightforward, highway-focused journey primarily on US Highway 287, with a brief section on US 82. Given its duration, this route is very manageable as a single-day trip, perfect for getting to your destination efficiently. You can expect a fuel cost of around $55 for this drive. Both Anna and Amarillo are situated within the Great Plains region, so you'll be traversing familiar, open landscapes for the entirety of your journey.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
181.5 miles from Anna, TX
A natural place for your longest stop of the day
, about 3h 23m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 39m. Total distance: 363 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 39m drive, plan rest stops for pacing.
Drive Character
Expect a highway-focused experience for about 73% of this 363-mile trip. The majority of your time will be spent on US Highway 287, which offers consistent cruising speeds. You'll encounter one stretch of uninterrupted driving for 75.4 miles, providing a good opportunity to settle into a rhythm. While the route is predominantly highway, the transition between US Highway 287 and US 82 is seamless, keeping the drive flowing without significant detours or complex navigation.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 44 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US Highway 287 is the longest continuous segment at about 75.4 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on US Highway 287 and US 82. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near FM 2862 / West 4th Street.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 17 significant decision points across 363 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: near the start (FM 2862 / West 4th Street): Navigation decision point; at 23.6 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 141 miles (US 287 / Northwest Freeway): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 17 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
4
0 mi into trip|~0m in|FM 2862 / West 4th Street
Turn left onto FM 2862 / West 4th Street
Navigation decision point
5
23.6 mi into trip|~29m in
Take the exit toward US 82: Bonham, Gainesville
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward US 82: Bonham, Gainesville
9
141 mi into trip|~2h 40m in|US 287 / Northwest Freeway
Keep slight left at fork onto US 287 / Northwest Freeway toward US 287 North: Vernon, Amarillo
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / straight lanes.
Exit 3A
Toward US 287 North: Vernon, Amarillo
5
353.1 mi into trip|~6h 26m in|East Interstate Drive
Keep slight right at fork onto East Interstate Drive toward East 3rd Avenue
Highway fork - watch signs carefully
Toward East 3rd Avenue
5
357.3 mi into trip|~6h 31m in
Take the exit toward US 60, I 40 Business: Amarillo Boulevard
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward US 60, I 40 Business: Amarillo Boulevard
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Anna, TX to Amarillo, TX, road signs begin pointing toward Gainesville along the way.
Gainesville
23.6 mi in|~29m
Main Roads
Road
Distance
Duration
US Highway 287
75.4 mi
1h 17m
US 82
59.6 mi
1h 5m
US Highway 287 East
40.5 mi
42m
East 11th Street
28.7 mi
32m
Boykin Drive
26.2 mi
28m
US Highway 287 West
25.7 mi
26m
East Buck Owens Freeway
19.2 mi
20m
East US Highway 82
12.3 mi
14m
Longest stretch:
US Highway 287
— 75.4 mi, about 1h 17m
Turn-by-Turn Driving Directions
Step-by-step road directions between Anna, TX and Amarillo, TX.
1
Start on South Sherley Road
35 ft·8 sec·South Sherley Road
2
Turn left onto FM 2862
0.2 mi·20 sec·West 4th Street
3
Turn right onto TX 5
2.8 mi·4 min·North Powell Parkway
4
Continue on TX 5
0.8 mi·1 min·State Highway 5
5
Turn left onto County Road 375
0.8 mi·3 min·County Road 375
6
Turn right onto South Henry Hynds Expressway Frontage Road
0.2 mi·26 sec·South Henry Hynds Expressway Frontage Road
7
Take the ramp
0.2 mi·26 sec
8
Merge onto US 75
9.8 mi·9 min·South Henry Hynds Expressway
9
Continue on US 75
8.8 mi·9 min·South Sam Rayburn Freeway
Use the straight / slight right lanes.
10
Take the exit
0.2 mi·29 sec
Toward US 82: Bonham, Gainesville
11
Turn straight onto North Sam Rayburn Freeway
0.3 mi·42 sec·North Sam Rayburn Freeway
12
Turn left onto East Highway 82
0.3 mi·31 sec·East Highway 82
13
Take the ramp
0.1 mi·13 sec
14
Merge onto US 82
19 mi·20 min·East Buck Owens Freeway
15
Continue on US 82
12 mi·14 min·East US Highway 82
Use the straight / right lanes.
16
Continue on US 82
12 mi·13 min·J M Lindsay Boulevard
17
Continue on US 82
10 mi·11 min·Division Street
18
Turn straight onto US 82
25 mi·27 min·US 82
19
Merge onto US 82
35 mi·37 min·US 82
20
Continue on US 281; US 287
0.8 mi·58 sec·Lloyd Ruby Overpass
21
Continue on US 277; US 281; US 287
2.4 mi·3 min·Central Freeway
Use the straight lane.
22
Keep slight left at fork onto US 287
5.3 mi·5 min·Northwest Freeway
Exit 3AToward US 287 North: Vernon, AmarilloUse the slight left / straight lanes.
23
Continue on US 287
40 mi·42 min·US Highway 287 East
Use the straight / left / right lanes.
24
Continue on US 70; US 183; US 287
4.1 mi·4 min·Martin Luther King Jr Memorial Highway
Use the straight / slight right lanes.
25
Continue on US 287
26 mi·26 min·US Highway 287 West
Use the straight lane.
26
Continue on US 287
29 mi·32 min·East 11th Street
27
Continue on US 287
2.8 mi·3 min·Avenue F Northeast
28
Continue on US 287
14 mi·14 min·US Highway 287
29
Continue on US 287
0.7 mi·1 min·Burnett Street
30
Continue on US 287
14 mi·13 min·US Highway 287
31
Turn straight onto US 287
26 mi·28 min·Boykin Drive
32
Continue on US 287
1.6 mi·1 min·East 2nd Street
33
Continue on US 287
28 mi·28 min·US Highway 287
34
Continue on US 287; FM 1151
1.1 mi·2 min·East 1st Street
35
Continue on US 287
20 mi·20 min·US Highway 287
36
Keep slight right at fork onto East Interstate Drive
329 ft·8 sec·East Interstate Drive
Toward East 3rd Avenue
37
Keep slight right at fork onto Southeast 3rd Avenue
2.6 mi·3 min·Southeast 3rd Avenue
38
Take the ramp
0.2 mi·26 sec
39
Merge onto Loop 335
1.3 mi·1 min·North Lakeside Drive
40
Take the exit
0.3 mi·46 sec
Toward US 60, I 40 Business: Amarillo Boulevard
41
Turn left onto I 40 Business; US Historic 66; US 60
4.4 mi·5 min·East Amarillo Boulevard
42
Continue on I 40 Business; Original US Route 66; US 60
0.9 mi·1 min·I 40 Business; Original US Route 66; US 60
43
Continue on I 40 Business
0.1 mi·17 sec·East Amarillo Boulevard
44
Arrive at destination
I 40 Business; Original US Route 66; US 60
Trip Plan
For this 6-hour and 39-minute drive, consider departing in the morning to maximize daylight. Since this is a single-day trip, you have the flexibility to take breaks as needed, with only one recommended stop factored in. Keep an eye on your fuel levels, especially during the longest stretch of 75.4 miles on US Highway 287, as services can sometimes be spaced out on these highways. A practical tip is to check your tire pressure before you leave Anna, TX, as consistent highway speeds can impact it over the 363 miles.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 181.5 miles from Anna, TX, or about 3h 23m into the drive.
The longest continuous stretch on this route runs about 75.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 33m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 181.5 miles or 3h 23m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 33m
Traffic, exits, and arrival timing usually matter more near Amarillo, TX than in the middle of the route.
Before You Leave
+
Open the route before leaving Anna, TX so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Anna, TX
This is one driving day of about 363 miles and 6h 39m.
Your first comfortable stop window is around 80 miles from Anna, TX.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US Highway 287 for about 75.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 181.5 mi from Anna, TX
· 3h 23m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Alibates Flint Quarries National Monument
National Monument
13,000 years ago, Alibates Flint was used by mammoth hunters as a source of flint for tools. Learn how important this site was to the survival, commerce, and culture of the people of the High Plains.
26 mi from route
~66 min detour
Free
near mile 363
Set within the wide‑open Texas Plains, Lake Meredith National Recreation Area offers a peaceful retreat in the heart of rugged grasslands. Over thousands of years, the Canadian River carved dramatic 2...
29 mi from route
~72 min detour
Free
near mile 363
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$54.85 one way
$109.70 round trip
$3.84/gal25.4 MPG avg127 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.20
$60.04
$120.08
premium
$4.54
$64.81
$129.62
diesel
$5.61
$80.15
$160.29
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$55
Meals
$25–$50
Total
$80–$105
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 127 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $38 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
108.9
1
$38.11
$17.42
Efficient EV
90.8
1
$31.76
$14.52
EV Truck/SUV
145.2
1
$50.82
$23.23
Gas CO2
127 kg
EV CO2
42 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Anna, TX
Late night
in Anna on Saturday
Local time
3:26 AM
CDT
Current temp
59°F
Unavailable
Live forecast
Destination
Amarillo, TX
Late night
in Amarillo on Saturday
Local time
3:26 AM
CDT
Current temp
84°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
25 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 39m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Anna, TX to Amarillo, TX covers 363 miles and takes about 6h 39m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US Highway 287, US 82, US Highway 287 East. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 181.5 miles from Anna, TX. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $54.85 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 17 significant decision points across 363 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: near the start (FM 2862 / West 4th Street): Navigation decision point; at 23.6 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 141 miles (US 287 / Northwest Freeway): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
On the drive from Anna, TX to Amarillo, TX, road signs begin pointing toward Gainesville along the way.
Yes. Nearby national parks include Alibates Flint Quarries National Monument and Lake Meredith National Recreation Area.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.
