The drive from Biloxi, MS to Booneville, MS covers 338.1 miles and takes about 6h 36m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on US 45, Lance Corporal Roy M Wheat Memorial Highway, US Highway 45 Alternate for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 90.9 miles on US 45.
At current regular gas prices, budget about $51.06 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
169 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 3h 15m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 36m. Total distance: 338.1 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 36m drive, plan rest stops for pacing.
Drive Character
This is a 6h 36m highway drive covering 338.1 miles, with most of the trip on US 45 and Lance Corporal Roy M Wheat Memorial Highway. The longest continuous stretch is about 90.9 miles on US 45.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 27 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 45 is the longest continuous segment at about 90.9 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on US 45 and Lance Corporal Roy M Wheat Memorial Highway. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 18 significant decision points across 338.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 159.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 18 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
7
70.4 mi into trip|~1h 26m in|US 98
Take the exit onto US 98 toward I 59 North, US 98 West: Columbia, Laurel
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 59 North, US 98 West: Columbia, Laurel
8
159.6 mi into trip|~3h 3m in|I 59
Keep slight right at fork onto I 59 toward I 59 North, I 20 East: Meridian, Tuscaloosa
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Toward I 59 North, I 20 East: Meridian, Tuscalo...
6
168.6 mi into trip|~3h 14m in
Take the exit toward US 45 North: Macon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Toward US 45 North: Macon
8
234 mi into trip|~4h 29m in|US 45 ALT / US Highway 45 Alternate
Keep slight left at fork onto US 45 ALT / US Highway 45 Alternate toward US 45 Alternate North: West Point, Tupelo
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight left lanes.
Toward US 45 Alternate North: West Point, Tupel...
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and Booneville, MS, road signs point toward Jackson, Laurel, Tuscaloosa and Tupelo.
Jackson
25.1 mi in|~32m
Laurel
70.4 mi in|~1h 26m|via US 98
Tuscaloosa
159.6 mi in|~3h 3m|via I 59
Tupelo
234 mi in|~4h 29m|via US 45 ALT
Main Roads
Road
Distance
Duration
US 45
90.9 mi
1h 44m
Lance Corporal Roy M Wheat Memorial Highway
88.4 mi
1h 35m
US Highway 45 Alternate
53 mi
1h 3m
US 49
42.2 mi
49m
MS 15
20.7 mi
24m
Martin Luther King Drive
18.1 mi
20m
I 59
9 mi
10m
Martin Luther King, Junior Drive
3.3 mi
4m
Longest stretch:
US 45
— 90.9 mi, about 1h 44m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Booneville, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Take the exit
0.3 mi·51 sec
12
Merge onto US 98
2.5 mi·2 min·US 98
Use the straight / slight right lanes.
13
Take the exit onto US 98
0.8 mi·1 min·US 98
Toward I 59 North, US 98 West: Columbia, LaurelUse the straight / slight right lanes.
14
Merge onto I 59; US 98
88 mi·1 hr 35 min·Lance Corporal Roy M Wheat Memorial Highway
Use the straight / slight right lanes.
15
Keep slight right at fork onto I 59
9.0 mi·10 min·I 59
Toward I 59 North, I 20 East: Meridian, TuscaloosaUse the straight lane.
16
Take the exit
0.3 mi·47 sec
Toward US 45 North: MaconUse the slight right lane.
17
Merge onto US 45
65 mi·1 hr 14 min·US 45
Use the straight lane.
18
Keep slight left at fork onto US 45 ALT
53 mi·1 hr 3 min·US Highway 45 Alternate
Toward US 45 Alternate North: West Point, TupeloUse the straight / slight left lanes.
19
Continue on US 45 ALT
18 mi·20 min·Martin Luther King Drive
20
Continue on US 45; MS 6
3.3 mi·4 min·Martin Luther King, Junior Drive
Use the straight / slight right lanes.
21
Keep slight right at fork onto US 45
26 mi·29 min·US 45
Use the straight / slight left lanes.
22
Take the exit onto MS 30
1.0 mi·1 min·MS 30
Toward MS 30 East: South Booneville, Tishomingo
23
Turn slight right
0.2 mi·34 sec
Toward MS 145: Booneville
24
Keep slight right at fork
226 ft·8 sec
Toward Booneville
25
Turn straight onto MS 145
2.8 mi·4 min·South 2nd Street
26
Turn right onto Washington Street
28 ft·0 sec·Washington Street
27
Arrive at destination
Washington Street
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 169 miles from Biloxi, MS, or about 3h 15m into the drive.
The longest continuous stretch on this route runs about 90.9 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 74 miles or 1h 31m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 169 miles or 3h 15m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 22m
Traffic, exits, and arrival timing usually matter more near Booneville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 338.1 miles and 6h 36m.
Your first comfortable stop window is around 74 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 45 for about 90.9 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 169 mi from Biloxi, MS
· 3h 15m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Natchez Trace National Scenic Trail
National Scenic Trail
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
3 mi from route
~6 min detour
Free
near mile 314.8
Park Closure: Partial Closure of Rocky Springs Trail
Park Closure: Temporary Blackland Prairie Trail Closure to Equestrians
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
4 mi from route
~10 min detour
Free
near mile 303.1
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$51.06 one way
$102.12 round trip
$3.84/gal25.4 MPG avg118 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$56.05
$112.11
premium
$4.56
$60.68
$121.37
diesel
$5.61
$74.65
$149.30
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$51
Meals
$25–$50
Total
$76–$101
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 118.3 kg one way.
Prices: EIA weekly data, 2026-04-13.
EV Charging Along Route
11 DC fast chargers
· Coverage: excellent
Electric Vehicle Charging Station
Biloxi, Mississippi
Other
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
ChargePoint Charging Station
Tupelo, Mississippi
ChargePoint
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
ChargePoint Charging Station
Tupelo, Mississippi
ChargePoint
1 DCFC
Electric Vehicle Charging Station
Biloxi, Mississippi
Other
1 DCFC
Tesla Destination: 4
ChargePoint: 4
Other: 3
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $36 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
101.4
1
$35.50
$16.23
Efficient EV
84.5
0
$29.58
$13.52
EV Truck/SUV
135.2
1
$47.33
$21.64
Gas CO2
118 kg
EV CO2
40 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 17, 2026
Origin
Biloxi, MS
Morning
in Biloxi on Friday
Local time
11:39 AM
CDT
Current temp
61°F
Unavailable
Live forecast
Destination
Booneville, MS
Morning
in Booneville on Friday
Local time
11:39 AM
CDT
Current temp
87°F
Sunny
SSW 5 to 10 mph4% chanceLive forecast
79°F
Meridian, MS
169 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
26 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 36m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Biloxi, MS to Booneville, MS covers 338.1 miles and takes about 6h 36m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 45, Lance Corporal Roy M Wheat Memorial Highway, US Highway 45 Alternate. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 169 miles from Biloxi, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $51.06 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 18 significant decision points across 338.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 159.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Biloxi, MS and Booneville, MS, road signs point toward Jackson, Laurel, Tuscaloosa and Tupelo.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, NREL for EV charging, and NPS for national parks. See our methodology for refresh cadence and limitations.
