The drive from Biloxi, MS to Byram, MS covers 158.4 miles and takes about 3h 20m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on US 49, MS 15, Florence Byram Road for much of the mileage,
and the overall profile is highway-focused drive.
The longest uninterrupted segment is about 125 miles on US 49.
At current regular gas prices, budget about $23.92 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
79.2 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 1h 40m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 3h 20m. Total distance: 158.4 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
3h 20m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (94%). Some complex stretches to watch for.
Drive Character
This is a 3h 20m highway drive covering 158.4 miles, with most of the trip on US 49 and MS 15. The longest continuous stretch is about 125 miles on US 49.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 24 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 49 is the longest continuous segment at about 125 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on US 49 and MS 15. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near Main Street.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 9 significant decision points across 158.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: near the start (Main Street): Navigation decision point; at 1 miles (Bohn Street): Navigation decision point; at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 9 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
3
0 mi into trip|~0m in|Main Street
Turn right onto Main Street
Navigation decision point
4
1 mi into trip|~3m in|Bohn Street
Take the ramp onto Bohn Street
Navigation decision point
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
5
25.5 mi into trip|~33m in|US 49
Merge onto US 49
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
4
153.5 mi into trip|~3h 12m in|Florence Byram Road
Keep slight left at fork onto Florence Byram Road
Highway fork - watch signs carefully
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Biloxi, MS to Byram, MS, road signs begin pointing toward Jackson along the way.
Jackson
25.1 mi in|~32m
Main Roads
Road
Distance
Duration
US 49
125 mi
2h 32m
MS 15
20.7 mi
24m
Florence Byram Road
3.7 mi
6m
I 110
3.1 mi
4m
West Main Street
1.7 mi
4m
Florence-Byram Road
1.4 mi
2m
Division Street
0.5 mi
1m
Main Street
0.5 mi
1m
Longest stretch:
US 49
— 125 mi, about 2h 32m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Byram, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Turn straight onto US 49
10 mi·16 min·US 49
Use the straight lane.
12
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
13
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
14
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
15
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
16
Continue on US 49
57 mi·1 hr 8 min·US 49
Use the straight lane.
17
Turn left onto MS 469
0.5 mi·49 sec·MS 469
18
Continue on West Main Street
1.7 mi·4 min·West Main Street
19
Continue on Florence Byram Road
0.8 mi·1 min·Florence Byram Road
20
Keep slight left at fork onto Florence Byram Road
2.9 mi·5 min·Florence Byram Road
21
Continue on Florence-Byram Road
1.4 mi·2 min·Florence-Byram Road
22
Continue on Swinging Bridge Road
0.4 mi·45 sec·Swinging Bridge Road
23
Continue on Old Byram Road
0.2 mi·16 sec·Old Byram Road
24
Arrive at destination
South Siwell Road
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 79.2 miles from Biloxi, MS, or about 1h 40m into the drive.
The longest continuous stretch on this route runs about 125 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 35 miles or 44m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 79.2 miles or 1h 40m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 40m
Traffic, exits, and arrival timing usually matter more near Byram, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 158.4 miles and 3h 20m.
Your first comfortable stop window is around 35 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 125 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 79.2 mi from Biloxi, MS
· 1h 40m into the drive
Place data sourced from public business listings. Hours and availability may vary.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
11 mi from route
~28 min detour
Free
near mile 158.4
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $17 in charging
· 0 stops
· 65% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
47.5
0
$16.63
$7.60
Efficient EV
39.6
0
$13.86
$6.34
EV Truck/SUV
63.4
0
$22.18
$10.14
Gas CO2
55 kg
EV CO2
19 kg (65% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Biloxi, MS
Afternoon
in Biloxi on Friday
Local time
12:44 PM
CDT
Current temp
61°F
Unavailable
Live forecast
Destination
Byram, MS
Afternoon
in Byram on Friday
Local time
12:44 PM
CDT
Current temp
55°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
6 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
3h 20m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Biloxi, MS to Byram, MS covers 158.4 miles and takes about 3h 20m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 49, MS 15, Florence Byram Road. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 79.2 miles from Biloxi, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $23.92 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. A short stop every 2 to 3 hours is enough for this drive.
This is a demanding drive. With 9 significant decision points across 158.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: near the start (Main Street): Navigation decision point; at 1 miles (Bohn Street): Navigation decision point; at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
On the drive from Biloxi, MS to Byram, MS, road signs begin pointing toward Jackson along the way.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, NREL for EV charging, and NPS for national parks. See our methodology for refresh cadence and limitations.
