Origin
Biloxi, MS
Afternoon in Biloxi on Saturday
Local time
12:31 PM
CDT
Current temp
61°F
Unavailable
Live forecast
Trip from Biloxi, MS to Fulton, MS
Compiled and reviewed by the Trip.ovh planning team at COD Solutions Oy · Last reviewed Apr 18, 2026 · Editorial standards
Drive Time
6h 25m
Distance
328.1 mi
528 km
Drive Score
10/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$50
one way
EV Charging
Unknown
Best Time to Leave
4 AM
6h 13m
★
6 AM
6h 25m
8 AM
6h 50m
10 AM
6h 34m
12 PM
6h 32m
3 PM
6h 35m
5 PM
6h 49m
8 PM
6h 18m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Biloxi, MS
Wikimedia Commons
Fulton, MS
大 董
Trip Overview
Biloxi, MS to Fulton, MS is 328.1 miles and takes about 6h 25m via Lance Corporal Roy M Wheat Memorial Highway and US 45, with a fuel budget near $50 and enough daylight to finish in a day. This drive stays within Mississippi, beginning in the Southeast region and ending in the same area. It's a single-day trip focused on highway travel, making it a straightforward journey. If you're looking for an efficient way to get from the Gulf Coast inland within the state, this route gets you there without much fuss. Budgeting around $50 for fuel should cover the 328.1 miles.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
164 miles from Biloxi, MS
A natural place for your longest stop of the day , about 3h 8m into the drive .
Main Roads
| Road | Distance | Duration |
|---|---|---|
| Lance Corporal Roy M Wheat Memorial Highway | 88.4 mi | 1h 35m |
| US 45 | 65.1 mi | 1h 14m |
| US Highway 45 Alternate | 53 mi | 1h 3m |
| US 49 | 42.2 mi | 49m |
| MS 15 | 20.7 mi | 24m |
| Martin Luther King Drive | 18.1 mi | 20m |
| I 22 | 14.3 mi | 15m |
| I 59 | 9 mi | 10m |
Longest stretch:
Lance Corporal Roy M Wheat Memorial Highway
— 88.4 mi, about 1h 35m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Fulton, MS.
1
Start on Howard Avenue
91 ft
·
6 sec
·
Howard Avenue
2
Turn right onto Main Street
0.5 mi
·
1 min
·
Main Street
3
Turn left onto Division Street
0.5 mi
·
1 min
·
Division Street
4
Take the ramp onto Bohn Street
139 ft
·
3 sec
·
Bohn Street
5
Turn straight
0.3 mi
·
37 sec
6
Merge onto I 110
3.1 mi
·
4 min
·
I 110
7
Continue on MS 15; MS 67
21 mi
·
24 min
·
MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi
·
47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi
·
46 min
·
US 49
Use the straight lane.
10
Continue on US 49
2.4 mi
·
2 min
·
US 49
Use the straight / slight right lanes.
11
Take the exit
0.3 mi
·
51 sec
12
Merge onto US 98
2.5 mi
·
2 min
·
US 98
Use the straight / slight right lanes.
13
Take the exit onto US 98
0.8 mi
·
1 min
·
US 98
Toward I 59 North, US 98 West: Columbia, Laurel
Use the straight / slight right lanes.
14
Merge onto I 59; US 98
88 mi
·
1 hr 35 min
·
Lance Corporal Roy M Wheat Memorial Highway
Use the straight / slight right lanes.
15
Keep slight right at fork onto I 59
9.0 mi
·
10 min
·
I 59
Toward I 59 North, I 20 East: Meridian, Tuscaloosa
Use the straight lane.
16
Take the exit
0.3 mi
·
47 sec
Toward US 45 North: Macon
Use the slight right lane.
17
Merge onto US 45
65 mi
·
1 hr 14 min
·
US 45
Use the straight lane.
18
Keep slight left at fork onto US 45 ALT
53 mi
·
1 hr 3 min
·
US Highway 45 Alternate
Toward US 45 Alternate North: West Point, Tupelo
Use the straight / slight left lanes.
19
Continue on US 45 ALT
18 mi
·
20 min
·
Martin Luther King Drive
20
Take the exit
0.3 mi
·
38 sec
Toward Eason Boulevard
21
Turn straight onto South Eason Boulevard
4.9 mi
·
7 min
·
South Eason Boulevard
22
Continue on CR 931
0.1 mi
·
20 sec
·
Auburn Road
23
Take the ramp
0.3 mi
·
45 sec
24
Merge onto I 22; US 78
14 mi
·
15 min
·
I 22; US 78
25
Take the exit
0.3 mi
·
41 sec
Toward Fulton, Amory
26
Turn slight left onto South Adams Street
2.2 mi
·
4 min
·
South Adams Street
27
At end of road, turn left onto MS 178
0.5 mi
·
1 min
·
East Main Street
28
Turn right onto North Cummings Street
121 ft
·
3 sec
·
North Cummings Street
29
Arrive at destination
North Cummings Street
Trip Plan
Given the 6h 25m duration, starting your drive from Biloxi in the morning is recommended to ensure you have ample daylight. With only one recommended stop and a compact 328.1-mile distance, you have flexibility in pacing. Keep an eye on your fuel levels, especially during the longest stretch of 88.4 miles on Lance Corporal Roy M Wheat Memorial Highway, as services might be spaced out. The estimated fuel cost of $50 is a good baseline, but it's always wise to have a little extra. This route is easily manageable in a single day, so focus on enjoying the straightforward travel through Mississippi.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 164 miles from Biloxi, MS, or about 3h 8m into the drive.
The longest continuous stretch on this route runs about 88.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 72 miles or 1h 29m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 164 miles or 3h 8m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 11m
Traffic, exits, and arrival timing usually matter more near Fulton, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 328.1 miles and 6h 25m.
Your first comfortable stop window is around 72 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Lance Corporal Roy M Wheat Memorial Highway for about 88.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Mid-route town
Meal stop
164 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 72 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 164 miles from Biloxi, MS, which is a good place for a longer meal and fuel stop.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Heads-up: tricky spots
5 of 195 decision points cluster between mile 25.1 and 234 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
25.1 mi into trip
|
~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
7
70.4 mi into trip
|
~1h 26m in
|
US 98
Take the exit onto US 98 toward I 59 North, US 98 West: Columbia, Laurel
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 59 North, US 98 West: Columbia, Laurel
8
159.6 mi into trip
|
~3h 3m in
|
I 59
Keep slight right at fork onto I 59 toward I 59 North, I 20 East: Meridian, Tuscaloosa
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Toward I 59 North, I 20 East: Meridian, Tuscalo...
6
168.6 mi into trip
|
~3h 14m in
Take the exit toward US 45 North: Macon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Toward US 45 North: Macon
8
234 mi into trip
|
~4h 29m in
|
US 45 ALT / US Highway 45 Alternate
Keep slight left at fork onto US 45 ALT / US Highway 45 Alternate toward US 45 Alternate North: West Point, Tupelo
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight left lanes.
Toward US 45 Alternate North: West Point, Tupel...
Fuel & Cost
Regular Gas
$49.55 one way
$99.10 round trip
$3.84/gal
25.4 MPG avg
115 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.21 | $54.39 | $108.79 |
| premium | $4.56 | $58.89 | $117.78 |
| diesel | $5.61 | $72.44 | $144.88 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$50
Meals
$25–$50
Total
$75–$100
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 114.8 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $34 in charging · 1 stop · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 98.4 | 1 | $34.45 | $15.75 |
| Efficient EV | 82 | 0 | $28.71 | $13.12 |
| EV Truck/SUV | 131.2 | 1 | $45.93 | $21.00 |
Gas CO2
115 kg
EV CO2
38 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Fulton, MS
Afternoon in Fulton on Saturday
Local time
12:31 PM
CDT
Current temp
53°F
Unavailable
Live forecast
79°F
Meridian, MS
164 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
8 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 25m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Tupelo National Battlefield
National Battlefield
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
3 mi from route
~6 min detour
Free
near mile 305.4
View on nps.gov
Natchez Trace National Scenic Trail
National Scenic Trail
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
7 mi from route
~16 min detour
Free
near mile 305.4
View on nps.gov
Park data from the National Park Service API. Alerts update every 2 hours.
What kind of drive is this?
This is a highway-focused drive, with 64% of the route utilizing major highways. You'll experience a significant stretch of 88.4 miles on Lance Corporal Roy M Wheat Memorial Highway, offering a good amount of uninterrupted driving. The journey primarily follows US 45 and US Highway 45 Alternate, providing a consistent pace for most of the 6h 25m trip. Expect a mix of efficient highway travel rather than winding local roads, making it a predictable drive from start to finish.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 29 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Lance Corporal Roy M Wheat Memorial Highway is the longest continuous segment at about 88.4 miles.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on Lance Corporal Roy M Wheat Memorial Highway and US 45. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort
10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 328.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 159.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and Fulton, MS, road signs point toward Jackson, Laurel, Tuscaloosa and Tupelo.
Jackson
25.1 mi in
|
~32m
Laurel
70.4 mi in
|
~1h 26m
|
via US 98
Tuscaloosa
159.6 mi in
|
~3h 3m
|
via I 59
Tupelo
234 mi in
|
~4h 29m
|
via US 45 ALT
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 25m. Total distance: 328.1 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 25m drive, plan rest stops for pacing.
Frequently Asked Questions
The drive from Biloxi, MS to Fulton, MS covers 328.1 miles and takes about 6h 25m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Lance Corporal Roy M Wheat Memorial Highway, US 45, US Highway 45 Alternate. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 164 miles from Biloxi, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $49.55 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 19 significant decision points across 328.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 159.6 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Biloxi, MS and Fulton, MS, road signs point toward Jackson, Laurel, Tuscaloosa and Tupelo.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, and NPS for national parks. See our methodology for refresh cadence and limitations.
Was this helpful?
Thanks for your feedback!
Your tip has been submitted. Thanks!
/500
Recent Tips
·
Explore More
Continue From Fulton, MS
Explore more options from Biloxi, MS or browse trips ending in Fulton, MS.
Looking for more statewide routes? Browse MS road trips.