Trip from Cabool, MO to St. Louis, MO

Drive Time

3h 22m

Distance

171.1 mi

275 km

Drive Score

8/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$26

one way

EV Charging

Loading...

station data

Best Time to Leave

Save up to 36 min
4 AM
3h 11m ★
6 AM
3h 23m
8 AM
3h 47m
10 AM
3h 31m
12 PM
3h 29m
3 PM
3h 32m
5 PM
3h 46m
8 PM
3h 16m

Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.

Downtown Cabool, MO, MO

Cabool, MO

Collab Media

Trip Overview

Traveling from Cabool to St. Louis covers 171.1 miles and typically takes about 3 hours and 22 minutes behind the wheel. Because this journey is well within the limits of a comfortable day trip, there is no need to book an overnight stay unless you prefer a leisurely pace. You will primarily navigate the region using US-63, the Officer Michael Barwick Memorial Highway, and I-44. With fuel costs estimated at approximately $26, it is an affordable trek across the Missouri Midwest. Whether you are heading to the city for business or a change of scenery, this highway-focused route offers a straightforward connection between these two points.

Trip Pace

Same-day drive is realistic

A same-day return is realistic if you keep stops short.

Break Rhythm

1 planned break

A short stop every 2 to 3 hours is enough for this drive.

Midpoint

85.5 miles from Cabool, MO

A natural place for your longest stop of the day , about 1h 44m into the drive .

Drive Character

Expect a highly efficient journey, as 93% of your travel time is spent on highways. The route features a significant 94.8-mile stretch on I-44, which serves as the backbone of your drive and allows for consistent cruising speeds. Transitioning from the local sections onto the interstate creates a distinct shift in pace, moving you from regional roads onto a major thoroughfare. This profile is decidedly highway-focused, prioritizing speed and connectivity over winding backroads. You will find that the road maintains a predictable flow, making it a reliable choice for drivers who prefer a direct path to their destination.

Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 16 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 44 is the longest continuous segment at about 94.8 miles.

Elevation Profile

Mostly flat terrain

1,287 ft 464 ft

Total Climb

371 ft

Total Descent

1,195 ft

Highest Point

1,287 ft

Elevation Range

823 ft

How Hard Is This Drive?

This is a straightforward highway drive that stays mostly on I 44 and US 63. You will hit about 9 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near US 60 Business / Ozark Street.

Route Complexity 6/10

Moderate - straightforward overall, but long enough or busy enough to require pacing

This drive requires moderate attention. Across 171.1 miles you will encounter 9 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.

Where does it get tricky?

The main spots that need attention: near the start (US 60 Business / Ozark Street): Navigation decision point; at 0.6 miles (US 63): Lane positioning matters here; at 64.9 miles (I 44 Business; US Historic 66; US 63 / North Bishop Avenue): Highway fork - watch signs carefully.

Critical Maneuvers

5 of 9 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

5
0 mi into trip | ~0m in | US 60 Business / Ozark Street

Turn left onto US 60 Business / Ozark Street

Navigation decision point

5
0.6 mi into trip | ~1m in | US 63

Turn left onto US 63

Lane positioning matters here

Use the left lane.
5
64.9 mi into trip | ~1h 21m in | I 44 Business; US Historic 66; US 63 / North Bishop Avenue

Keep slight left at fork onto I 44 Business; US Historic 66; US 63 / North Bishop Avenue

Highway fork - watch signs carefully

7
65.2 mi into trip | ~1h 22m in

Take the ramp toward I 44 East: Saint Louis

Lane positioning matters here

Use the slight right lane. Toward I 44 East: Saint Louis
7
168.6 mi into trip | ~3h 17m in

Take the exit toward Jefferson Avenue

Exit ramp - move to the correct lane early. Lane positioning matters here

Use the slight right lane. Exit 289 Toward Jefferson Avenue

Main Roads

Road Distance Duration
I 44 94.8 mi 1h 44m
US 63 64.3 mi 1h 20m
Officer Michael Barwick Memorial Highway 3.5 mi 4m
Police Officer Robert Stanze Memorial Highway 2.7 mi 3m
Officer David Haynes Memorial Highway 2.3 mi 3m
South Jefferson Avenue 1.3 mi 2m
Market Street 1 mi 1m
Ozark Avenue 0.3 mi <1m
Longest stretch: I 44 — 94.8 mi, about 1h 44m

Turn-by-Turn Driving Directions

Step-by-step road directions between Cabool, MO and St. Louis, MO.

1

Start on this road

120 ft · 14 sec · this road
2

Turn left onto US 60 Business

0.3 mi · 27 sec · Ozark Street
3

Continue on US 60 Business

0.3 mi · 33 sec · Ozark Avenue
4

Turn left onto US 63

64 mi · 1 hr 20 min · US 63
Use the left lane.
5

Continue on I 44 Business; US Historic 66; US 63

287 ft · 4 sec · North Bishop Avenue
6

Keep slight left at fork onto I 44 Business; US Historic 66; US 63

183 ft · 3 sec · North Bishop Avenue
7

Keep slight right at fork onto MO E

0.3 mi · 32 sec · Tim Bradley Way
8

Take the ramp

0.1 mi · 13 sec
Toward I 44 East: Saint Louis Use the slight right lane.
9

Merge onto I 44

95 mi · 1 hr 44 min · I 44
Use the none lane.
10

Continue on I 44

2.7 mi · 3 min · Police Officer Robert Stanze Memorial Highway
Use the none lane.
11

Continue on I 44

3.5 mi · 4 min · Officer Michael Barwick Memorial Highway
Use the none lane.
12

Continue on I 44

2.3 mi · 3 min · Officer David Haynes Memorial Highway
Use the none lane.
13

Take the exit

0.2 mi · 21 sec
Exit 289 Toward Jefferson Avenue Use the slight right lane.
14

Turn left onto South Jefferson Avenue

1.3 mi · 2 min · South Jefferson Avenue
Use the none lane.
15

Turn right onto Market Street

1.0 mi · 1 min · Market Street
Use the none lane.
16

Arrive at destination

Market Street

Trip Plan

Since the total drive time is relatively short, you have plenty of flexibility in your departure schedule to avoid peak traffic in St. Louis. Plan for at least one stop to break up the 171.1-mile journey, which helps keep you alert and comfortable. Keep an eye on your fuel gauge during the longer interstate segments, though the $26 estimated cost is manageable for most vehicles. Because the vast majority of your trip relies on I-44, monitor local traffic reports for that specific corridor before you head out. Embracing this as a single-day trip allows you to maximize your time in the city rather than spending unnecessary hours on the road.

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 85.5 miles from Cabool, MO, or about 1h 44m into the drive.
The longest continuous stretch on this route runs about 94.8 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 80 miles or 1h 38m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 85.5 miles or 1h 44m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 2h 45m

Traffic, exits, and arrival timing usually matter more near St. Louis, MO than in the middle of the route.

Before You Leave

+

Open the route before leaving Cabool, MO so your first major turns are already loaded.

+

Leave with enough water and a charging cable within reach, not packed away.

+

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Cabool, MO

This is one driving day of about 171.1 miles and 3h 22m.

Your first comfortable stop window is around 80 miles from Cabool, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 44 for about 94.8 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 85.5 mi from Cabool, MO · 1h 44m into the drive

Downtown Cahokia, IL, IL

Mid-route town

Meal stop

Cahokia, IL

86 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

Cahokia, IL

Fuel and coffee

A short stop after about 80 miles helps settle the day before fatigue starts building.

Cahokia, IL

Meal break

The midpoint is around 85.5 miles from Cabool, MO, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before I 44 if your tank is already low. That segment runs about 94.8 miles.

Arriving in St. Louis, MO

The final approach into St. Louis, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around St. Louis, MO.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$25.99 one way

$51.98 round trip

$3.86/gal 25.4 MPG avg 60 kg CO2
Fuel Type $/gal One Way Round Trip
midgrade $4.25 $28.65 $57.30
premium $4.80 $32.30 $64.60
diesel $5.64 $38.01 $76.02

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$26

Meals

$25–$50

Total

$51–$76

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 59.9 kg one way. Prices: EIA weekly data, 2026-04-06.

Driving Electric?

About $18 in charging · 0 stops · 67% less CO2

Vehicle Type kWh Stops DC Fast Home Charge
Average EV 51.3 0 $17.97 $8.21
Efficient EV 42.8 0 $14.97 $6.84
EV Truck/SUV 68.4 0 $23.95 $10.95

Gas CO2

60 kg

EV CO2

20 kg (67% less)

This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 6 hours ago

Origin

Cabool, MO

Afternoon in Cabool on Sunday

Local time

3:35 PM

CDT

Current temp

42°F

Unavailable

Live forecast

Destination

St. Louis, MO

Afternoon in St. Louis on Sunday

Local time

3:35 PM

CDT

Current temp

59°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

17 degrees warmer at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

3h 22m on the road

Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Cabool, MO to St. Louis, MO covers 171.1 miles and takes about 3h 22m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 44, US 63, Officer Michael Barwick Memorial Highway. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 85.5 miles from Cabool, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $25.99 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. A short stop every 2 to 3 hours is enough for this drive.
This drive requires moderate attention. Across 171.1 miles you will encounter 9 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
The main spots that need attention: near the start (US 60 Business / Ozark Street): Navigation decision point; at 0.6 miles (US 63): Lane positioning matters here; at 64.9 miles (I 44 Business; US Historic 66; US 63 / North Bishop Avenue): Highway fork - watch signs carefully.
The route from Cabool, MO to St. Louis, MO does not surface many named destination signs beyond the main corridor.
Mostly flat terrain. The route ranges from 464 ft to 1,287 ft elevation with about 371 ft of total climbing.

Was this route helpful?

Thanks for your feedback!

Your tip has been submitted. Thanks!

/500

Explore More

Return Trip

St. Louis, MO to Cabool, MO

Plan the drive back the other way.

171.2 mi 3h 22m

Explore more options from Cabool, MO or browse trips ending in St. Louis, MO.

Looking for more statewide routes? Browse MO road trips.

Explore maps for Cabool, MO or St. Louis, MO on MapSof.net.