Drive Time
2h 17m
Distance
115.1 mi
185 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$17
one way
Photo: cottonbro studio
The drive from Cape Girardeau, MO to Clayton, MO covers 115.1 miles and takes about 2h 17m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on North Kingshighway, I 55 North, Rosa Parks Highway for much of the mileage, and the overall profile is turn-heavy local drive. At current regular gas prices, budget about $17.48 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
0 planned breaks
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
57.5 miles from Cape Girardeau, MO
A natural place for your longest stop of the day , about 1h 8m into the drive .
Expect a 2h 17m drive with frequent turns across 115.1 miles of local and secondary roads.
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. Navigation is very simple — set it and forget it for most of the drive.
Very easy - short and simple to drive
The drive from Cape Girardeau, MO to Clayton, MO is easy. At 2h 17m with 0% highway, most drivers will find it relaxed and low-stress.
Where does it get tricky?
This route does not have any notably tricky sections. Most of the drive from Cape Girardeau, MO to Clayton, MO is straightforward, with well-signed roads and simple exits.
| Road | Distance | Duration |
|---|---|---|
| North Kingshighway | Unavailable | Refreshing |
| I 55 North | Unavailable | Refreshing |
| Rosa Parks Highway | Unavailable | Refreshing |
| Reavis Barracks Road | Unavailable | Refreshing |
| Mackenzie Road | Unavailable | Refreshing |
| Reavis Road | Unavailable | Refreshing |
| Tesson Ferry Road | Unavailable | Refreshing |
| South Rock Hill Road | Unavailable | Refreshing |
Per-road distance and duration are being refreshed from OSRM for this route.
Step-by-step road directions between Cape Girardeau, MO and Clayton, MO.
Start on Broadway Street
Turn right onto North Kingshighway
Take the ramp slight right toward I 55 North: Saint Louis
Merge slight left
Continue on Rosa Parks Highway
Take the exit slight right toward Reavis Barracks Road
Turn left onto Reavis Barracks Road
Continue on Mackenzie Road
Turn left onto Reavis Road
Turn right onto Tesson Ferry Road
Continue on South Rock Hill Road
Turn slight right
Turn straight onto Laclede Station Road
Continue on South Hanley Road
Turn right onto Wydown Boulevard
Turn right onto Hillvale Drive
Arrive at your destination
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 35m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 57.5 miles or 1h 8m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 1h 53m
Traffic, exits, and arrival timing usually matter more near Clayton, MO than in the middle of the route.
Open the route before leaving Cape Girardeau, MO so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Cape Girardeau, MO
This is one driving day of about 115.1 miles and 2h 17m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 57.5 mi from Cape Girardeau, MO · 1h 8m into the drive
Mid-route town
Meal stop
58 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 80 miles helps settle the day before fatigue starts building.
The midpoint is around 57.5 miles from Cape Girardeau, MO, which is a good place for a longer meal and fuel stop.
The final approach into Clayton, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Clayton, MO.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$17.48 one way
$34.97 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.25 | $19.27 | $38.54 |
| premium | $4.80 | $21.73 | $43.46 |
| diesel | $5.64 | $25.57 | $51.14 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$17
Meals
$25–$50
Total
$42–$67
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 40.3 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $12 in charging · 0 stops · 68% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 34.5 | 0 | $12.09 | $5.52 |
| Efficient EV | 28.8 | 0 | $10.07 | $4.60 |
| EV Truck/SUV | 46 | 0 | $16.11 | $7.37 |
Gas CO2
40 kg
EV CO2
13 kg (68% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive. If you're planning ahead, check the forecast closer to your travel date.
Origin
Evening in Cape Girardeau on Saturday
Local time
5:48 PM
CDT
Current temp
62°F
Forecast unavailable right now
Destination
Evening in Clayton on Saturday
Local time
5:48 PM
CDT
Current temp
81°F
Forecast unavailable right now
Along the Route
59°F
Cahokia, IL
58 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
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