The drive from Glendale, MO to Independence, MO covers 418.9 miles and takes about 8h 9m behind the wheel.
It usually feels better as a 2-day road trip than as one long push.
The route leans on I 55, Dwight D Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway for much of the mileage,
and the overall profile is mixed drive.
The longest uninterrupted segment is about 162 miles on I 55.
At current regular gas prices, budget about $65.49 one way before food or hotel costs.
Trip Pace
Best split across 2 days
Treat the return leg as its own travel day rather than an afterthought.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
209.4 miles from Glendale, MO
A natural place for your longest stop of the day
, about 4h 10m into the drive
.
Who Is This Route For?
Solo Traveler
8h 9m drive, plan rest stops for pacing.
Scenic Drive
Mixed drive route profile with national parks nearby.
Drive Character
The drive from Glendale, MO to Independence, MO covers 418.9 miles and takes about 8h 9m, using a mix of highways and local roads.
Expect a mix of faster highway mileage and slower local approaches near the beginning or end.
There are about 34 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 55 is the longest continuous segment at about 162 miles.
How Hard Is This Drive?
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 179.3 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 20 significant decision points across 418.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 179.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 179.5 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 191.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 20 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
8
179.3 mi into trip|~3h 32m in
Take the exit toward I 270 West, I 255 East: Kansas City, Chicago
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 196
Toward I 270 West, I 255 East: Kansas City, Chi...
8
179.5 mi into trip|~3h 32m in
Keep slight left at fork toward I 270 West: Kansas City
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left lane.
Toward I 270 West: Kansas City
8
191.8 mi into trip|~3h 48m in
Take the exit toward I 64, US 40, US 61: Wentzville, Saint Louis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 12
Toward I 64, US 40, US 61: Wentzville, Saint Lo...
8
192 mi into trip|~3h 48m in
Keep slight left at fork toward I 64 West, US 40 West, US 61 North: Wentzville
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Toward I 64 West, US 40 West, US 61 North: Went...
8
217.9 mi into trip|~4h 20m in|US 40
Take the exit onto US 40 toward I 70 West, US 40 West: Kansas City
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight left lanes.
Exit 1A
Toward I 70 West, US 40 West: Kansas City
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Glendale, MO and Independence, MO, road signs point toward Chicago and Saint Louis.
Chicago
179.3 mi in|~3h 32m
Saint Louis
191.8 mi in|~3h 48m
Main Roads
Road
Distance
Duration
I 55
162 mi
2h 54m
Dwight D Eisenhower Highway
80.7 mi
1h 35m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Dwight D. Eisenhower Highway
54.3 mi
58m
Avenue of the Saints
25.4 mi
30m
I 270
11.5 mi
14m
MO 162
9.8 mi
17m
South Noland Road
3 mi
5m
Longest stretch:
I 55
— 162 mi, about 2h 54m
Turn-by-Turn Driving Directions
Step-by-step road directions between Glendale, MO and Independence, MO.
1
Start on MO VV
0.4 mi·1 min·MO VV
2
Continue on County Road 282
1.0 mi·4 min·County Road 282
3
Turn left onto County Road 281
1.7 mi·6 min·County Road 281
4
Continue on County Road 277
1.1 mi·4 min·County Road 277
5
Turn right onto MO 162
9.8 mi·17 min·MO 162
6
At end of road, turn right onto US 61; MO 162
1.0 mi·1 min·US 61; MO 162
7
Turn left onto US 61; MO 162
0.7 mi·1 min·US 61; MO 162
8
Take the ramp
0.2 mi·24 sec
Toward I 55 North: Sikeston
9
Merge onto I 55
60 mi·1 hr 4 min·I 55
10
Keep slight left at fork onto I 55
102 mi·1 hr 49 min·I 55
11
Continue on I 55
1.3 mi·1 min·Rosa Parks Highway
12
Take the exit
0.2 mi·27 sec
Exit 196Toward I 270 West, I 255 East: Kansas City, ChicagoUse the slight right lane.
13
Keep slight left at fork
388 ft·8 sec
Toward I 270 West: Kansas CityUse the slight left lane.
14
Continue on this road
0.7 mi·1 min·this road
Exit 196Toward I 270 West
15
Merge onto I 270
11 mi·14 min·I 270
Use the straight lane.
16
Take the exit
0.1 mi·17 sec
Exit 12Toward I 64, US 40, US 61: Wentzville, Saint LouisUse the slight right lane.
17
Keep slight left at fork
0.4 mi·48 sec
Toward I 64 West, US 40 West, US 61 North: WentzvilleUse the slight left lane.
18
Continue on this road
0.1 mi·9 sec·this road
Exit 12Toward I 64 West, US 40 West, US 61 North: Wentzville
19
Merge onto I 64; US 40; US 61
25 mi·30 min·Avenue of the Saints
Use the straight lane.
20
Take the exit onto US 40
0.6 mi·1 min·US 40
Exit 1AToward I 70 West, US 40 West: Kansas CityUse the straight / slight left lanes.
21
Merge onto I 70; US 40
81 mi·1 hr 35 min·Dwight D Eisenhower Highway
22
Continue on I 70; US 40
2.0 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
23
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
24
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
25
Continue on I 70; US 40
54 mi·58 min·U.S. Submarine Veterans' Memorial Highway
The midpoint is around 209.4 miles from Glendale, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel check
Top up before I 55 if your tank is already low. That segment runs about 162 miles.
Overnight split
Hotel stop
For a steadier pace, wrap day one after about 209 miles or 4.1 hours on the road.
Arriving in Independence, MO
The final approach into Independence, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Independence, MO.
On a multi-day trip, keep the last day a little lighter so you reach Independence, MO with some flexibility left in the schedule.
After long uninterrupted mileage, take five minutes before the last urban segment to reset and refocus on exits, merges, and city traffic.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
National Parks Near This Route
Worth a detour if your schedule allows.
Ste. Geneviève National Historical Park
National Historical Park
Established by 1750, Ste. Geneviève was the first permanent European settlement in Missouri. Early French Canadian settlers were drawn here by the rich agricultural land known as Le Grand Champ (the B...
5 mi from route
~13 min detour
Free
near mile 125.2
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
14 mi from route
~35 min detour
$19
near mile 180.8
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$65.49 one way
$130.98 round trip
$3.97/gal25.4 MPG avg147 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$71.91
$143.81
premium
$4.89
$80.61
$161.23
diesel
$5.61
$92.49
$184.98
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$65
Hotel (1n)
$80–$140
Meals
$50–$100
Total
$195–$305
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 146.6 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $44 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
125.7
1
$43.98
$20.11
Efficient EV
104.7
1
$36.65
$16.76
EV Truck/SUV
167.6
2
$58.65
$26.81
Gas CO2
147 kg
EV CO2
49 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Glendale, MO
Evening
in Glendale on Thursday
Local time
8:28 PM
CDT
Current temp
55°F
Unavailable
Live forecast
Destination
Independence, MO
Evening
in Independence on Thursday
Local time
8:28 PM
CDT
Current temp
73°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
For long drives, weather on day two can matter just as much as conditions at departure, so check the whole travel window rather than only the first day.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
18 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
8h 9m on the road
This is long enough that the arrival forecast matters almost as much as departure conditions. Recheck both ends before you roll.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Glendale, MO to Independence, MO covers 418.9 miles and takes about 8h 9m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 55, Dwight D Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway. Expect a mix of highway and local road driving.
Consider an overnight stop or starting very early.
Yes. This route is usually more comfortable as a 2-day drive. A sensible stopping point is after roughly 209 miles on day one.
The midpoint is about 209.4 miles from Glendale, MO. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $65.49 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 2 meaningful breaks for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 20 significant decision points across 418.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 179.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 179.5 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 191.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Glendale, MO and Independence, MO, road signs point toward Chicago and Saint Louis.
Yes. Nearby national parks include Ste. Geneviève National Historical Park and Gateway Arch National Park.
