Trip from Perryville, MO to Independence, MO

Drive Time

5h 54m

Distance

306.9 mi

494 km

Drive Score

9/10

Great drive

Same Day?

Yes, doable

Fuel Cost

$47

one way

Best Time Drive vs Fly

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Perryville, MO

Valeria Boltneva

Independence, MO

Ever Rayan

Trip Overview

Crossing Missouri from Perryville to Independence covers 306.9 miles and typically takes about 5 hours and 54 minutes behind the wheel. Because this is a manageable distance within a single state, you can easily complete the journey in one day, though you should budget approximately $47 for fuel. Your path primarily utilizes the Dwight D. Eisenhower Highway, I-55, and the U.S. Submarine Veterans' Memorial Highway. Navigating through the heart of the Midwest, this route offers a straightforward transition between these two Missouri cities. It is a practical choice for travelers looking to move efficiently between regions without the need for an overnight stay.

Trip Pace

Same-day drive is realistic

A same-day return is possible, but it will make for a full day on the road.

Break Rhythm

1 planned break

Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Midpoint

153.5 miles from Perryville, MO

A natural place for your longest stop of the day , about 3h 1m into the drive .

Drive Character

Expect a turn-heavy local drive that balances interstate travel with more nuanced road conditions. Only 23% of the journey consists of highway driving, meaning you will spend a significant portion of the trip navigating local segments. The longest uninterrupted stretch you will encounter is 80.7 miles along the Dwight D. Eisenhower Highway, providing a brief period of consistent momentum. As you progress, the personality of the road shifts, requiring you to stay alert through the various turns rather than settling into a monotonous interstate grind. This mix of road types ensures the driving experience remains engaging from start to finish.

This route has more turning and local-road decision points than a simple highway run.

There are about 34 navigation steps in the underlying route data, so the final approach matters more than the middle miles.

Dwight D Eisenhower Highway is the longest continuous segment at about 80.7 miles.

How Hard Is This Drive?

Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 67.3 miles in.

Route Complexity 9/10

High effort - long or complex enough to need steady focus all day

This is a demanding drive. With 19 significant decision points across 306.9 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.

Where does it get tricky?

The main spots that need attention: at 67.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 67.6 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 79.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.

Critical Maneuvers

5 of 19 key points

These are the spots where you need to pay the most attention. Preview them before you drive.

67.3 mi into trip | ~1h 17m in

Take the exit toward I 270 West, I 255 East: Kansas City, Chicago

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Exit 196 Toward I 270 West, I 255 East: Kansas City, Chi...

67.6 mi into trip | ~1h 17m in

Keep slight left at fork toward I 270 West: Kansas City

Highway fork - watch signs carefully. Lane positioning matters here

Use the slight left lane. Toward I 270 West: Kansas City

79.9 mi into trip | ~1h 33m in

Take the exit toward I 64, US 40, US 61: Wentzville, Saint Louis

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight right lane. Exit 12 Toward I 64, US 40, US 61: Wentzville, Saint Lo...

80 mi into trip | ~1h 33m in

Keep slight left at fork toward I 64 West, US 40 West, US 61 North: Wentzville

Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one

Use the slight left lane. Toward I 64 West, US 40 West, US 61 North: Went...

105.9 mi into trip | ~2h 5m in | US 40

Take the exit onto US 40 toward I 70 West, US 40 West: Kansas City

Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one

Use the straight / slight left lanes. Exit 1A Toward I 70 West, US 40 West: Kansas City

Towns Along This Route

Between Perryville, MO and Independence, MO, road signs point toward Chicago and Saint Louis.

Chicago

67.3 mi in | ~1h 17m

Saint Louis

79.9 mi in | ~1h 33m

Main Roads

Road	Distance	Duration
Dwight D Eisenhower Highway	80.7 mi	1h 35m
I 55	59.4 mi	1h 4m
U.S. Submarine Veterans' Memorial Highway	54.4 mi	58m
Dwight D. Eisenhower Highway	54.3 mi	58m
Avenue of the Saints	25.4 mi	30m
I 270	11.5 mi	14m
South Noland Road	3 mi	5m
North King's Highway	2.8 mi	4m

Longest stretch: Dwight D Eisenhower Highway — 80.7 mi, about 1h 35m

Turn-by-Turn Driving Directions

Step-by-step road directions between Perryville, MO and Independence, MO.

Start on South Spring Street

221 ft · 15 sec · South Spring Street

Turn left onto East Saint Joseph Street

365 ft · 16 sec · East Saint Joseph Street

Turn right onto MO B

349 ft · 10 sec · North Main Street

Continue on MO B

0.4 mi · 1 min · North Main Street

Enter roundabout onto US 61

194 ft · 3 sec · North Kingshighway Street

Continue on US 61

2.4 mi · 3 min · North Kingshighway Street

Continue on US 61

2.8 mi · 4 min · North King's Highway

Turn left onto MO M

0.5 mi · 1 min · MO M

Take the ramp

0.2 mi · 27 sec

Toward I 55 North: Saint Louis

Merge onto I 55

59 mi · 1 hr 4 min · I 55

Continue on I 55

1.3 mi · 1 min · Rosa Parks Highway

Use the none lane.

Take the exit

0.2 mi · 27 sec

Exit 196 Toward I 270 West, I 255 East: Kansas City, Chicago Use the slight right lane.

Keep slight left at fork

388 ft · 8 sec

Toward I 270 West: Kansas City Use the slight left lane.

Continue on this road

0.7 mi · 1 min · this road

Exit 196 Toward I 270 West

Merge onto I 270

11 mi · 14 min · I 270

Use the none lane.

Take the exit

0.1 mi · 17 sec

Exit 12 Toward I 64, US 40, US 61: Wentzville, Saint Louis Use the slight right lane.

Keep slight left at fork

0.4 mi · 48 sec

Toward I 64 West, US 40 West, US 61 North: Wentzville Use the slight left lane.

Continue on this road

0.1 mi · 9 sec · this road

Exit 12 Toward I 64 West, US 40 West, US 61 North: Wentzville

Merge onto I 64; US 40; US 61

25 mi · 30 min · Avenue of the Saints

Use the straight lane.

Take the exit onto US 40

0.6 mi · 1 min · US 40

Exit 1A Toward I 70 West, US 40 West: Kansas City Use the straight / slight left lanes.

Merge onto I 70; US 40

81 mi · 1 hr 35 min · Dwight D Eisenhower Highway

Continue on I 70; US 40

2.0 mi · 2 min · Sheriff Roger I. Wilson Memorial Highway

Continue on I 70; US 40

1.6 mi · 1 min · Highway Patrol Sgt. Benjamin Booth Memorial Highway

Continue on I 70; US 40

1.8 mi · 2 min · Dwight D. Eisenhower Highway

Continue on I 70; US 40

54 mi · 58 min · U.S. Submarine Veterans' Memorial Highway

Continue on I 70; US 40

52 mi · 56 min · Dwight D. Eisenhower Highway

Use the none lane.

Continue on I 70

2.7 mi · 3 min · Truman/Eisenhower Presidential Highway

Use the none lane.

Continue on I 70

1.4 mi · 1 min · Clifton J. Scott Memorial Highway

Use the none / straight / slight right lanes.

Take the exit

0.2 mi · 23 sec

Exit 12 Toward Noland Road Use the straight / slight right lanes.

Turn right onto South Noland Road

3.0 mi · 5 min · South Noland Road

Turn left onto East Walnut Street

466 ft · 22 sec · East Walnut Street

Turn right onto South Lynn Street

394 ft · 22 sec · South Lynn Street

Turn left onto East Kansas Avenue

145 ft · 6 sec · East Kansas Avenue

Arrive at destination

East Kansas Avenue

Trip Plan

Since you are looking at a nearly six-hour trek, plan for at least one dedicated stop to stretch your legs and refresh. Aim to depart early in the morning to avoid fatigue, as the technical nature of the turn-heavy local roads requires your full attention. Keep a close eye on your fuel gauge, especially when transitioning off the highway segments, to ensure you stay within your $47 budget. Flexibility is your greatest advantage on this trip, so don't hesitate to adjust your pace if you encounter unexpected local traffic. A helpful tip for this specific route is to prioritize your fuel stops during the 80.7-mile stretch on the Eisenhower Highway, where services are most predictable.

Morning Departure

An early start around 7-8 AM gets you there with plenty of daylight left.

Evening Departure

A late afternoon start means arriving after dark. Morning is better.

You can normally do this drive in one day.

Plan roughly 1 meaningful break for fuel, food, and rest.

The halfway point lands around 153.5 miles from Perryville, MO, or about 3h 1m into the drive.

The longest continuous stretch on this route runs about 80.7 miles.

This is a comfortable same-day trip.

Departure

Before you leave

Start with fuel, water, and navigation already sorted so the first hour feels easy.

First stop

Around 80 miles or 1h 33m in

Use this first pause for coffee, a restroom break, and a quick traffic check ahead.

Halfway reset

Around 153.5 miles or 3h 1m in

This is the best place for your longest stop, a real meal, and a full fuel check.

Final approach

Final hour starts around 4h 51m

Traffic, exits, and arrival timing usually matter more near Independence, MO than in the middle of the route.

Before You Leave

Open the route before leaving Perryville, MO so your first major turns are already loaded.

Leave with enough water and a charging cable within reach, not packed away.

Check your fuel range against the first long segment, especially if you are starting outside city service areas.

Day 1

Settle into the route from Perryville, MO

This is one driving day of about 306.9 miles and 5h 54m.

Your first comfortable stop window is around 80 miles from Perryville, MO.

This route can stay practical as a one-day drive if traffic stays reasonable.

Plan about 1 real break rather than only quick fuel stops.

The longest stretch is on Dwight D Eisenhower Highway for about 80.7 miles.

Where to Stop

Rest stops, refuel points, and overnight suggestions along this route.

Halfway Point

Midpoint

About 153.5 mi from Perryville, MO · 3h 1m into the drive

Mid-route town

Meal stop

Alton, IL

153 mi into the route

Best for: Lunch, fuel, and a longer reset

This sits close to the middle of the route, so it works well for the longest stop of the day.

Pacing Suggestions

East Saint Louis, IL

Fuel and coffee

A short stop after about 80 miles helps settle the day before fatigue starts building.

Quincy, IL

Meal break

The midpoint is around 153.5 miles from Perryville, MO, which is a good place for a longer meal and fuel stop.

Before the longest stretch

Fuel check

Top up before Dwight D Eisenhower Highway if your tank is already low. That segment runs about 80.7 miles.

Arriving in Independence, MO

The final approach into Independence, MO usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.

Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Independence, MO.

These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.

Fuel & Cost

Regular Gas

$46.61 one way

$93.23 round trip

$3.86/gal 25.4 MPG avg 107 kg CO₂

Fuel Type	$/gal	One Way	Round Trip
midgrade	$4.25	$51.39	$102.78
premium	$4.80	$57.94	$115.87
diesel	$5.64	$68.18	$136.37

No toll roads detected on this route.

Estimated Trip Cost (one way, 1 person)

Fuel

$47

Meals

$25–$50

Total

$72–$97

Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.

Estimated CO2 emission: 107.4 kg one way. Prices: EIA weekly data, 2026-04-06.

Driving Electric?

About $32 in charging · 1 stop · 66% less CO₂

Vehicle Type	kWh	Stops	DC Fast	Home Charge
Average EV	92.1	1	$32.22	$14.73
Efficient EV	76.7	0	$26.85	$12.28
EV Truck/SUV	122.8	1	$42.97	$19.64

Gas CO2

107 kg

EV CO2

36 kg (66% less)

Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.

DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.

Travel Intel

Current conditions at both ends of the drive.

Forecast data refreshed 2 days ago

Origin

Perryville, MO

Afternoon in Perryville on Sunday

Local time

2:22 PM

CDT

Current temp

79°F

Unavailable

Live forecast

Destination

Independence, MO

Afternoon in Independence on Sunday

Local time

2:22 PM

CDT

Current temp

49°F

Unavailable

Live forecast

Seasonal Notes

Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.

Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.

Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.

Time zone

Same local time

Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.

Temperature spread

30 degrees cooler at arrival

A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.

Road read

5h 54m on the road

An early start around 7-8 AM gets you there with plenty of daylight left.

Weather data from the National Weather Service. Conditions may change; check closer to your travel date.

Frequently Asked Questions

The drive from Perryville, MO to Independence, MO covers 306.9 miles and takes about 5h 54m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.

The main roads are Dwight D Eisenhower Highway, I 55, U.S. Submarine Veterans' Memorial Highway. Expect a mix of highway and local road driving.

This is a comfortable same-day trip.

The midpoint is about 153.5 miles from Perryville, MO. Look for rest areas, gas stations, or food options near the halfway mark.

At current regular gas prices, expect to spend about $46.61 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.

An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.

Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.

Between Perryville, MO and Independence, MO, road signs point toward Chicago and Saint Louis.

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Return Trip

Independence, MO to Perryville, MO

Plan the drive back the other way.

306.6 mi 5h 53m

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Trip from Perryville, MO to Independence, MO

Trip Overview

Drive Character

How Hard Is This Drive?

Critical Maneuvers

Towns Along This Route

Main Roads

Turn-by-Turn Driving Directions

Trip Plan

Before You Leave

Where to Stop

Pacing Suggestions

Arriving in Independence, MO

Fuel & Cost

Travel Intel

Perryville, MO

Independence, MO

Same local time

30 degrees cooler at arrival

5h 54m on the road

Frequently Asked Questions

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