The drive from Greenville, MS to Bay Saint Louis, MS covers 289.1 miles and takes about 6h 4m behind the wheel.
This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Highway 49 South, North Martin Luther King Drive, Lance Corporal Roy M Wheat Memorial Highway for much of the mileage,
and the overall profile is mixed drive.
The longest uninterrupted segment is about 80.3 miles on Highway 49 South.
At current regular gas prices, budget about $43.66 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
144.6 miles from Greenville, MS
A natural place for your longest stop of the day
, about 3h 1m into the drive
.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 4m. Total distance: 289.1 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 4m drive, plan rest stops for pacing.
Scenic Drive
Mixed drive route profile with national parks nearby.
Drive Character
The drive from Greenville, MS to Bay Saint Louis, MS covers 289.1 miles and takes about 6h 4m, using a mix of highways and local roads.
Expect a mix of faster highway mileage and slower local approaches near the beginning or end.
There are about 25 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Highway 49 South is the longest continuous segment at about 80.3 miles.
How Hard Is This Drive?
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 72.1 miles in near US 49W.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 17 significant decision points across 289.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 72.1 miles (US 49W): Highway fork - watch signs carefully; at 121.2 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 121.8 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 17 key points
These are the spots where you need to pay the most attention. Preview them before you drive.
5
72.1 mi into trip|~1h 31m in|US 49W
Keep slight right at fork onto US 49W toward US 49 South: Jackson
Highway fork - watch signs carefully
Toward US 49 South: Jackson
6
121.2 mi into trip|~2h 32m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward Meridian, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Meridian, Hattiesburg
6
121.8 mi into trip|~2h 32m in|US 49
Keep slight right at fork onto US 49 toward Richland, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Richland, Hattiesburg
7
204.3 mi into trip|~4h 14m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
6
204.7 mi into trip|~4h 14m in|I 59 / Lance Corporal Roy M Wheat Memorial Highway
Merge onto I 59 / Lance Corporal Roy M Wheat Memorial Highway toward Mississippi Gulf Coast
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
Toward Mississippi Gulf Coast
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Greenville, MS and Bay Saint Louis, MS, road signs point toward Meridian, Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast and Necaise.
Meridian
121.2 mi in|~2h 32m|via I 20; US 49
Hattiesburg
121.2 mi in|~2h 32m|via I 20; US 49
Richland
121.8 mi in|~2h 32m|via US 49
Gulf Coast
204.3 mi in|~4h 14m
Mississippi Gulf Coast
204.7 mi in|~4h 14m|via I 59
Necaise
244.8 mi in|~4h 57m
Main Roads
Road
Distance
Duration
Highway 49 South
80.3 mi
1h 37m
North Martin Luther King Drive
46.2 mi
55m
Lance Corporal Roy M Wheat Memorial Highway
40.1 mi
43m
Jerry Clower Boulevard
38.8 mi
47m
MS 603
25 mi
37m
US 82
15.8 mi
19m
South Main Street
15.7 mi
23m
US 49
11.5 mi
15m
Longest stretch:
Highway 49 South
— 80.3 mi, about 1h 37m
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenville, MS and Bay Saint Louis, MS.
1
Start on MS 814
10 ft·7 sec·South Broadway Street
2
Turn left onto Main Street
0.9 mi·2 min·Main Street
3
Turn left onto MS 182
9.2 mi·13 min·MS 182
4
Turn left onto US 82; US 278
16 mi·19 min·US 82; US 278
Use the straight lane.
5
Turn right onto US 49W
46 mi·55 min·North Martin Luther King Drive
6
Keep slight right at fork onto US 49W
0.5 mi·53 sec·US 49W
Toward US 49 South: Jackson
7
Merge onto US 49
39 mi·47 min·Jerry Clower Boulevard
8
Take the exit onto US 49
4.9 mi·5 min·US 49
9
Keep slight left at fork onto US 49
3.8 mi·5 min·US 49
10
Merge onto I 20; I 55; US 49
1.1 mi·1 min·I 20; I 55; US 49
11
Keep slight right at fork onto I 20; US 49
347 ft·4 sec·I 20; US 49
Toward Meridian, Hattiesburg
12
Take the exit onto US 49
0.6 mi·42 sec·US 49
Toward Hattiesburg
13
Keep slight right at fork onto US 49
0.7 mi·1 min·US 49
Toward Richland, Hattiesburg
14
Merge onto US 49
80 mi·1 hr 37 min·Highway 49 South
Use the straight lane.
15
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
16
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
17
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
18
Merge onto I 59
40 mi·43 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf CoastUse the straight lane.
19
Take the exit
0.2 mi·27 sec
Toward MS 53: Poplarville, Necaise
20
Turn left onto MS 53
16 mi·23 min·South Main Street
21
Continue on MS 603
25 mi·37 min·MS 603
22
Turn left onto US 90
2.1 mi·3 min·US 90
23
Turn right onto Main Street
1.1 mi·1 min·Main Street
24
Turn right onto South 2nd Street
0.2 mi·27 sec·South 2nd Street
25
Arrive at destination
South 2nd Street
Trip Plan
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 144.6 miles from Greenville, MS, or about 3h 1m into the drive.
The longest continuous stretch on this route runs about 80.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 64 miles or 1h 21m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 144.6 miles or 3h 1m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 49m
Traffic, exits, and arrival timing usually matter more near Bay Saint Louis, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Greenville, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Greenville, MS
This is one driving day of about 289.1 miles and 6h 4m.
Your first comfortable stop window is around 64 miles from Greenville, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Highway 49 South for about 80.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 144.6 mi from Greenville, MS
· 3h 1m into the drive
The midpoint is around 144.6 miles from Greenville, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel check
Top up before Highway 49 South if your tank is already low. That segment runs about 80.3 miles.
Arriving in Bay Saint Louis, MS
The final approach into Bay Saint Louis, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Bay Saint Louis, MS.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
4 mi from route
~9 min detour
Free
near mile 109.7
Park data from the National Park Service API. Alerts update every 2 hours.
Fuel & Cost
Regular Gas
$43.66 one way
$87.32 round trip
$3.84/gal25.4 MPG avg101 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$47.93
$95.86
premium
$4.56
$51.89
$103.78
diesel
$5.61
$63.83
$127.66
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$44
Meals
$25–$50
Total
$69–$94
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 101.2 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $30 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
86.7
1
$30.36
$13.88
Efficient EV
72.3
0
$25.30
$11.56
EV Truck/SUV
115.6
1
$40.47
$18.50
Gas CO2
101 kg
EV CO2
34 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Greenville, MS
Evening
in Greenville on Thursday
Local time
8:34 PM
CDT
Current temp
77°F
Unavailable
Live forecast
Destination
Bay Saint Louis, MS
Evening
in Bay Saint Louis on Thursday
Local time
8:34 PM
CDT
Current temp
88°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
11 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 4m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Greenville, MS to Bay Saint Louis, MS covers 289.1 miles and takes about 6h 4m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Highway 49 South, North Martin Luther King Drive, Lance Corporal Roy M Wheat Memorial Highway. Expect a mix of highway and local road driving.
This is a comfortable same-day trip.
The midpoint is about 144.6 miles from Greenville, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $43.66 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 17 significant decision points across 289.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 72.1 miles (US 49W): Highway fork - watch signs carefully; at 121.2 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 121.8 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Between Greenville, MS and Bay Saint Louis, MS, road signs point toward Meridian, Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast and Necaise.
Yes. Nearby national parks include Medgar and Myrlie Evers Home National Monument.
