Origin
Greenville, MS
Night in Greenville on Wednesday
Local time
9:55 PM
CDT
Current temp
77°F
Unavailable
Live forecast
Trip from Greenville, MS to Tupelo, MS
Last recalculated Apr 16, 2026
Drive Time
4h 2m
Distance
186.2 mi
300 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$28
one way
Best Time to Leave
4 AM
3h 50m
★
6 AM
4h 3m
8 AM
4h 29m
10 AM
4h 12m
12 PM
4h 9m
3 PM
4h 13m
5 PM
4h 27m
8 PM
3h 55m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Greenville, MS
Wikimedia Commons
Tupelo, MS
Wikimedia Commons
Trip Overview
This 186.2-mile drive from Greenville to Tupelo, Mississippi, is a straightforward journey across the Southeast region of the state. Expect to spend about 4 hours and 2 minutes on the road, making it a perfectly manageable day trip. The route primarily utilizes US 278 and US 61, with a small portion on MS 182, keeping you on highways for 95% of the trip. With an estimated fuel cost of $28, it’s an economical option for a single day's travel. This drive is focused on getting you from point A to point B efficiently, with one planned stop recommended to break up the journey.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
93.1 miles from Greenville, MS
A natural place for your longest stop of the day , about 1h 59m into the drive .
Drive Character
This route offers a highway-focused experience for nearly its entirety, with 95% of the drive on major roads. You'll encounter a significant uninterrupted stretch of 98 miles on US 278, which means you can settle in and cover a good distance without frequent turns. The primary roads, including US 61 and MS 182, are designed for steady progress, so anticipate a consistent driving pace. This isn't a winding scenic byway, but rather a functional route that prioritizes direct travel across Mississippi.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 14 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
US 278 is the longest continuous segment at about 98 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on US 278 and US 61. There are only a few real navigation decisions along the way. The trickiest moment comes early in the drive near Main Street.
Route Complexity
3/10
Easy - simple navigation with a manageable amount of wheel time
This is a straightforward 4h 2m drive. You will face about 8 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
The main spots that need attention: near the start (Main Street): Navigation decision point; at 0.9 miles (MS 182): Navigation decision point; at 11.7 miles (Griffin Road): Navigation decision point.
Critical Maneuvers
5 of 8 key pointsThese are the spots where you need to pay the most attention. Preview them before you drive.
4
0 mi into trip
|
~0m in
|
Main Street
Turn left onto Main Street
Navigation decision point
4
0.9 mi into trip
|
~2m in
|
MS 182
Turn left onto MS 182
Navigation decision point
4
11.7 mi into trip
|
~19m in
|
Griffin Road
At end of road, turn right onto Griffin Road
Navigation decision point
6
76.6 mi into trip
|
~1h 38m in
|
US 278
Keep slight right at fork onto US 278
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight lane.
4
186.2 mi into trip
|
~4h 2m in
|
North Spring Street
Turn left onto North Spring Street
Navigation decision point
Main Roads
| Road | Distance | Duration |
|---|---|---|
| US 278 | 98 mi | 2h 4m |
| US 61 | 64.4 mi | 1h 18m |
| MS 182 | 8.7 mi | 12m |
| West Main Street | 5.7 mi | 11m |
| Old Highway 6 | 5.6 mi | 7m |
| South Broad Street | 1.4 mi | 2m |
| Main Street | 0.9 mi | 2m |
| Old Hwy 61 | 0.8 mi | 1m |
Longest stretch:
US 278
— 98 mi, about 2h 4m
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenville, MS and Tupelo, MS.
1
Start on MS 814
10 ft
·
7 sec
·
South Broadway Street
2
Turn left onto Main Street
0.9 mi
·
2 min
·
Main Street
3
Turn left onto MS 182
8.7 mi
·
12 min
·
MS 182
4
Turn left onto South Broad Street
1.4 mi
·
2 min
·
South Broad Street
5
Turn straight onto Old Hwy 61
0.8 mi
·
1 min
·
Old Hwy 61
6
At end of road, turn right onto Griffin Road
145 ft
·
2 sec
·
Griffin Road
7
Turn left onto US 61; US 278
64 mi
·
1 hr 18 min
·
US 61; US 278
8
Take the exit onto US 278
0.4 mi
·
50 sec
·
US 278
9
Keep slight right at fork onto US 278
98 mi
·
2 hr 3 min
·
US 278
Use the straight lane.
10
Take the exit
0.7 mi
·
1 min
11
Turn straight onto Old Highway 6
5.6 mi
·
7 min
·
Old Highway 6
12
Continue on West Main Street
5.7 mi
·
11 min
·
West Main Street
Use the straight / right lanes.
13
Turn left onto North Spring Street
230 ft
·
10 sec
·
North Spring Street
14
Arrive at destination
North Spring Street
Trip Plan
Given the 4-hour duration, starting your drive from Greenville in the morning will allow you to reach Tupelo with plenty of daylight remaining. With only one recommended stop, plan for a mid-drive break around the 98-mile mark on US 278 to stretch your legs and refuel if needed, though the total fuel cost is only $28. Since this is a highway-centric trip, be mindful of speed limits and potential traffic, especially as you approach your destination. The single stop offers flexibility, so you can adjust your timing based on your personal pace.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 93.1 miles from Greenville, MS, or about 1h 59m into the drive.
The longest continuous stretch on this route runs about 98 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 41 miles or 54m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 93.1 miles or 1h 59m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 14m
Traffic, exits, and arrival timing usually matter more near Tupelo, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Greenville, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Greenville, MS
This is one driving day of about 186.2 miles and 4h 2m.
Your first comfortable stop window is around 41 miles from Greenville, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 278 for about 98 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 93.1 mi from Greenville, MS · 1h 59m into the drive
Mid-route town
Meal stop
93 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 41 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 93.1 miles from Greenville, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before US 278 if your tank is already low. That segment runs about 98 miles.
Arriving in Tupelo, MS
The final approach into Tupelo, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Tupelo, MS.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$28.12 one way
$56.24 round trip
$3.84/gal
25.4 MPG avg
65 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.21 | $30.87 | $61.74 |
| premium | $4.56 | $33.42 | $66.84 |
| diesel | $5.61 | $41.11 | $82.22 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$28
Meals
$25–$50
Total
$53–$78
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 65.1 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $20 in charging · 0 stops · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 55.9 | 0 | $19.55 | $8.94 |
| Efficient EV | 46.6 | 0 | $16.29 | $7.45 |
| EV Truck/SUV | 74.5 | 0 | $26.07 | $11.92 |
Gas CO2
65 kg
EV CO2
22 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Tupelo, MS
Night in Tupelo on Wednesday
Local time
9:55 PM
CDT
Current temp
78°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 2m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Greenville, MS to Tupelo, MS covers 186.2 miles and takes about 4h 2m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are US 278, US 61, MS 182. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 93.1 miles from Greenville, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $28.12 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a straightforward 4h 2m drive. You will face about 8 decision points, but nothing that requires special attention if you follow navigation.
The main spots that need attention: near the start (Main Street): Navigation decision point; at 0.9 miles (MS 182): Navigation decision point; at 11.7 miles (Griffin Road): Navigation decision point.
The route from Greenville, MS to Tupelo, MS does not surface many named destination signs beyond the main corridor.
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