Origin
Greenville, MS
Afternoon in Greenville on Friday
Local time
2:55 PM
CDT
Current temp
77°F
Unavailable
Live forecast
Trip from Greenville, MS to Gulfport, MS
Compiled and reviewed by the Trip.ovh planning team at COD Solutions Oy · Last reviewed Apr 17, 2026 · Editorial standards
Drive Time
5h 45m
Distance
278.6 mi
448 km
Drive Score
10/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$42
one way
EV Charging
Unknown
Best Time to Leave
4 AM
5h 33m
★
6 AM
5h 46m
8 AM
6h 12m
10 AM
5h 55m
12 PM
5h 52m
3 PM
5h 56m
5 PM
6h 11m
8 PM
5h 38m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Greenville, MS
Wikimedia Commons
Gulfport, MS
Wikimedia Commons
Trip Overview
The drive from Greenville, MS to Gulfport, MS covers 278.6 miles and takes about 5h 45m behind the wheel. This route is realistic as a one-day drive if you keep your stops efficient.
The route leans on Highway 49 South, US 49, North Martin Luther King Drive for much of the mileage, and the overall profile is highway-focused drive. The longest uninterrupted segment is about 80.3 miles on Highway 49 South. At current regular gas prices, budget about $42.08 one way before food or hotel costs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
139.3 miles from Greenville, MS
A natural place for your longest stop of the day , about 2h 54m into the drive .
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 45m. Total distance: 278.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 45m drive, comfortable solo distance.
Drive Character
This is a 5h 45m highway drive covering 278.6 miles, with most of the trip on Highway 49 South and US 49. The longest continuous stretch is about 80.3 miles on Highway 49 South.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 25 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
Highway 49 South is the longest continuous segment at about 80.3 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on Highway 49 South and US 49. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 121.2 miles in near I 20; US 49.
Driving Effort
10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 278.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 121.2 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 204.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 212.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 19 key pointsThese are the spots where you need to pay the most attention. Preview them before you drive.
6
121.2 mi into trip
|
~2h 32m in
|
I 20; US 49
Keep slight right at fork onto I 20; US 49 toward Meridian, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Meridian, Hattiesburg
7
204.3 mi into trip
|
~4h 14m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
7
212.4 mi into trip
|
~4h 23m in
|
US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
215.6 mi into trip
|
~4h 27m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
215.9 mi into trip
|
~4h 28m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Greenville, MS and Gulfport, MS, road signs point toward Meridian, Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast and Mobile - among others.
Meridian
121.2 mi in
|
~2h 32m
|
via I 20; US 49
Hattiesburg
121.2 mi in
|
~2h 32m
|
via I 20; US 49
Richland
121.8 mi in
|
~2h 32m
|
via US 49
Gulf Coast
204.3 mi in
|
~4h 14m
Mississippi Gulf Coast
204.7 mi in
|
~4h 14m
|
via I 59
Mobile
212.4 mi in
|
~4h 23m
|
via US 98
Multi Purpose Center
215.9 mi in
|
~4h 28m
Main Roads
| Road | Distance | Duration |
|---|---|---|
| Highway 49 South | 80.3 mi | 1h 37m |
| US 49 | 73.9 mi | 1h 32m |
| North Martin Luther King Drive | 46.2 mi | 55m |
| Jerry Clower Boulevard | 38.8 mi | 47m |
| US 82 | 15.8 mi | 19m |
| MS 182 | 9.2 mi | 13m |
| Lance Corporal Roy M Wheat Memorial Highway | 7.7 mi | 8m |
| US 98 | 3.2 mi | 4m |
Longest stretch:
Highway 49 South
— 80.3 mi, about 1h 37m
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenville, MS and Gulfport, MS.
1
Start on MS 814
10 ft
·
7 sec
·
South Broadway Street
2
Turn left onto Main Street
0.9 mi
·
2 min
·
Main Street
3
Turn left onto MS 182
9.2 mi
·
13 min
·
MS 182
4
Turn left onto US 82; US 278
16 mi
·
19 min
·
US 82; US 278
Use the straight lane.
5
Turn right onto US 49W
46 mi
·
55 min
·
North Martin Luther King Drive
6
Keep slight right at fork onto US 49W
0.5 mi
·
53 sec
·
US 49W
Toward US 49 South: Jackson
7
Merge onto US 49
39 mi
·
47 min
·
Jerry Clower Boulevard
8
Take the exit onto US 49
4.9 mi
·
5 min
·
US 49
9
Keep slight left at fork onto US 49
3.8 mi
·
5 min
·
US 49
10
Merge onto I 20; I 55; US 49
1.1 mi
·
1 min
·
I 20; I 55; US 49
11
Keep slight right at fork onto I 20; US 49
347 ft
·
4 sec
·
I 20; US 49
Toward Meridian, Hattiesburg
12
Take the exit onto US 49
0.6 mi
·
42 sec
·
US 49
Toward Hattiesburg
13
Keep slight right at fork onto US 49
0.7 mi
·
1 min
·
US 49
Toward Richland, Hattiesburg
14
Merge onto US 49
80 mi
·
1 hr 37 min
·
Highway 49 South
Use the straight lane.
15
Continue on US 49; MS 42
0.4 mi
·
35 sec
·
US 49; MS 42
Use the straight lane.
16
Continue on US 49; MS 42
1.1 mi
·
1 min
·
US 49; MS 42
Use the straight lane.
17
Take the exit
0.4 mi
·
36 sec
Toward I 59 South: New Orleans, Gulf Coast
Use the slight right lane.
18
Merge onto I 59
7.7 mi
·
8 min
·
Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf Coast
Use the straight lane.
19
Take the exit onto US 98
3.2 mi
·
4 min
·
US 98
Toward US 98 East: Lucedale, Mobile
Use the straight / slight right lanes.
20
Take the exit
0.3 mi
·
44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Use the straight / slight right lanes.
21
Keep slight left at fork
0.2 mi
·
27 sec
Toward Multi Purpose Center, Hattiesburg
Use the slight left / slight right lanes.
22
Turn right onto US 49
58 mi
·
1 hr 9 min
·
US 49
Use the straight lane.
23
Turn straight onto US 49
4.5 mi
·
7 min
·
US 49
Use the left / straight / right lanes.
24
Continue on US 49
215 ft
·
16 sec
·
25th Avenue
25
Arrive at destination
US 49
Trip Plan
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 139.3 miles from Greenville, MS, or about 2h 54m into the drive.
The longest continuous stretch on this route runs about 80.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 61 miles or 1h 17m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 139.3 miles or 2h 54m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 43m
Traffic, exits, and arrival timing usually matter more near Gulfport, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Greenville, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Greenville, MS
This is one driving day of about 278.6 miles and 5h 45m.
Your first comfortable stop window is around 61 miles from Greenville, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Highway 49 South for about 80.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 139.3 mi from Greenville, MS · 2h 54m into the drive
Mid-route town
Meal stop
139 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 61 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 139.3 miles from Greenville, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before Highway 49 South if your tank is already low. That segment runs about 80.3 miles.
Arriving in Gulfport, MS
The final approach into Gulfport, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Gulfport, MS.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$42.08 one way
$84.15 round trip
$3.84/gal
25.4 MPG avg
98 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.21 | $46.19 | $92.38 |
| premium | $4.56 | $50.01 | $100.01 |
| diesel | $5.61 | $61.51 | $123.02 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$42
Meals
$25–$50
Total
$67–$92
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 97.5 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $29 in charging · 1 stop · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 83.6 | 1 | $29.25 | $13.37 |
| Efficient EV | 69.7 | 0 | $24.38 | $11.14 |
| EV Truck/SUV | 111.4 | 1 | $39.00 | $17.83 |
Gas CO2
97 kg
EV CO2
33 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Gulfport, MS
Afternoon in Gulfport on Friday
Local time
2:55 PM
CDT
Current temp
66°F
Mostly Clear
SE 5 to 10 mph
0% chance
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
11 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 45m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Greenville, MS to Gulfport, MS covers 278.6 miles and takes about 5h 45m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are Highway 49 South, US 49, North Martin Luther King Drive. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 139.3 miles from Greenville, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $42.08 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
An early start around 7-8 AM gets you there with plenty of daylight left. A late afternoon start means arriving after dark. Morning is better.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 19 significant decision points across 278.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 121.2 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 204.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 212.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Greenville, MS and Gulfport, MS, road signs point toward Meridian, Hattiesburg, Richland, Gulf Coast, Mississippi Gulf Coast and Mobile - among others.
How this page is built
Compiled by the Trip.ovh planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, and EIA for fuel prices. See our methodology for refresh cadence and limitations.
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