Drive Time
4h 23m
Distance
208.8 mi
336 km
Drive Score
9/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$32
one way
Photo: 大 董
Traveling from Greenville to Hattiesburg spans 208.8 miles and takes approximately 4 hours and 23 minutes of driving time. Because this journey fits comfortably into a single day, you won't need to worry about booking an overnight stay unless you prefer a slower pace. You will primarily navigate via Highway 49 South, with transitions through North Martin Luther King Drive and Jerry Clower Boulevard. Expect to budget roughly $32 for fuel to complete the trip. Since both cities are located within the Southeast region of Mississippi, the drive offers a consistent look at the state's geography. It is a straightforward route that works well for travelers looking to get from the Delta region down toward the Pine Belt without a complicated itinerary.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
104.4 miles from Greenville, MS
A natural place for your longest stop of the day , about 2h 11m into the drive .
This trip features a mixed drive profile, offering a blend of fast-paced highway segments and local navigation. With 58% of the journey spent on highways, you will experience varied road conditions rather than a monotonous interstate grind. Your longest uninterrupted stretch occurs on Highway 49 South, where you will cover 80.3 miles at a time. The transition between different road types requires you to stay alert as you move from local thoroughfares like Jerry Clower Boulevard onto the primary highway arteries. You should anticipate a dynamic driving experience that shifts in intensity as you move through different traffic environments along the 208.8-mile path.
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 72.1 miles in near US 49W.
Demanding - plan breaks and stay ahead of the key maneuvers
This is a demanding drive. With 17 significant decision points across 208.8 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 72.1 miles (US 49W): Highway fork - watch signs carefully; at 121.2 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 121.8 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
These are the spots where you need to pay the most attention. Preview them before you drive.
Keep slight right at fork onto US 49W toward US 49 South: Jackson
Highway fork - watch signs carefully
Keep slight right at fork onto I 20; US 49 toward Meridian, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Keep slight right at fork onto US 49 toward Richland, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Merge onto US 49 / Highway 49 South
Merge point - match speed before joining. Lane positioning matters here
Turn left onto Old Highway 42
Lane positioning matters here
Between Greenville, MS and Hattiesburg, MS, road signs point toward Meridian and Richland.
Meridian
Richland
| Road | Distance | Duration |
|---|---|---|
| Highway 49 South | 80.3 mi | 1h 37m |
| North Martin Luther King Drive | 46.2 mi | 55m |
| Jerry Clower Boulevard | 38.8 mi | 47m |
| US 82 | 15.8 mi | 19m |
| US 49 | 12.8 mi | 17m |
| MS 182 | 9.2 mi | 13m |
| Old Highway 42 | 1.8 mi | 3m |
| North Main Street | 1.2 mi | 2m |
Step-by-step road directions between Greenville, MS and Hattiesburg, MS.
Start on MS 814
Turn left onto Main Street
Turn left onto MS 182
Turn left onto US 82; US 278
Turn right onto US 49W
Keep slight right at fork onto US 49W
Merge onto US 49
Take the exit onto US 49
Keep slight left at fork onto US 49
Merge onto I 20; I 55; US 49
Keep slight right at fork onto I 20; US 49
Take the exit onto US 49
Keep slight right at fork onto US 49
Merge onto US 49
Continue on US 49; MS 42
Continue on US 49; MS 42
Turn left onto Old Highway 42
Turn right onto North Main Street
Turn left onto Batson Street
Turn right
At end of road, turn right onto US 11
Arrive at destination
Planning your departure for the morning is your best bet to ensure you arrive in Hattiesburg with plenty of daylight to spare. Given the four-plus hour duration, scheduling at least one stop is recommended to break up the monotony of the highway stretches. Because you are only looking at a single stop, use your fuel budget of $32 to keep your tank topped off during that break, especially when transitioning off the longer 80.3-mile stretch of Highway 49. Flexibility is a major advantage here, as the manageable length allows you to adjust your pace based on traffic or personal preference. Keep a close eye on your navigation when moving through the local sections of Greenville to ensure a smooth start to your trek.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 41m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 104.4 miles or 2h 11m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 33m
Traffic, exits, and arrival timing usually matter more near Hattiesburg, MS than in the middle of the route.
Open the route before leaving Greenville, MS so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Greenville, MS
This is one driving day of about 208.8 miles and 4h 23m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 104.4 mi from Greenville, MS · 2h 11m into the drive
Mid-route town
Meal stop
104 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 80 miles helps settle the day before fatigue starts building.
The midpoint is around 104.4 miles from Greenville, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before Highway 49 South if your tank is already low. That segment runs about 80.3 miles.
The final approach into Hattiesburg, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Hattiesburg, MS.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$31.92 one way
$63.84 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.26 | $35.01 | $70.02 |
| premium | $4.61 | $37.90 | $75.79 |
| diesel | $5.64 | $46.39 | $92.78 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$32
Meals
$25–$50
Total
$57–$82
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 73.1 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $22 in charging · 0 stops · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 62.6 | 0 | $21.92 | $10.02 |
| Efficient EV | 52.2 | 0 | $18.27 | $8.35 |
| EV Truck/SUV | 83.5 | 1 | $29.23 | $13.36 |
Gas CO2
73 kg
EV CO2
24 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive. If you're planning ahead, check the forecast closer to your travel date.
Origin
Late night in Greenville on Sunday
Local time
3:57 AM
CDT
Current temp
67°F
Forecast unavailable right now
Destination
Late night in Hattiesburg on Sunday
Local time
3:57 AM
CDT
Current temp
64°F
Forecast unavailable right now
Along the Route
85°F
Magee, MS
104 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
An early start around 7-8 AM gets you there with plenty of daylight left.
Thanks for your feedback!
Your tip has been submitted. Thanks!
/500
Recent Tips
·
Explore more options from Greenville, MS or browse trips ending in Hattiesburg, MS.
Looking for more statewide routes? Browse MS road trips.
Explore maps for Greenville, MS or Hattiesburg, MS on MapSof.net.
