Drive Time
4h 5m
Distance
192.9 mi
310 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$29
one way
Photo: Dominik Gryzbon
Traveling from Greenville to Auburn, Mississippi, covers 192.9 miles across the Southeast. You should anticipate roughly 4 hours and 5 minutes of driving time, making this a very manageable single-day trip. With a fuel budget of approximately $29, the route is economically efficient for a weekend excursion or a straightforward transit. You will primarily navigate via US 278, US 61, and I-22 to complete the journey. Since both locations are within the same state, the transition feels consistent, allowing you to focus on the road rather than adjusting to new regional climates. Overall, it is a practical trek that fits easily into a busy schedule.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
96.4 miles from Greenville, MS
A natural place for your longest stop of the day , about 2h 3m into the drive .
This trip is heavily highway-focused, with 98% of your travel occurring on major thoroughfares. Expect a consistent pace behind the wheel, punctuated by a significant 92.3-mile stretch on US 278 that serves as the backbone of your journey. The road personality shifts from regional highway connections to the more structured environment of I-22, providing a steady flow for the majority of your time in the driver's seat. Because the route relies so heavily on high-speed roads, it offers a predictable experience that is ideal for those who prefer efficient transit over winding, technical backroads. You will find that the rhythm of the drive remains stable from start to finish.
This is a straightforward highway drive that stays mostly on US 278 and US 61. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 76.6 miles in near US 278.
Demanding - plan breaks and stay ahead of the key maneuvers
This is a demanding drive. With 14 significant decision points across 192.9 miles, you will need to stay alert — especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 76.6 miles (US 278): Highway fork - watch signs carefully. Lane positioning matters here; at 168.5 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 168.9 miles: Highway fork - watch signs carefully.
These are the spots where you need to pay the most attention. Preview them before you drive.
Keep slight right at fork onto US 278
Highway fork - watch signs carefully. Lane positioning matters here
Take the exit toward MS 9: Pontotoc, Sherman
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Keep slight left at fork toward MS 9 North: Sherman
Highway fork - watch signs carefully
Turn left onto MS 9
Lane positioning matters here
Take the exit toward I-22 East, US 78 East: Tupelo
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
On the drive from Greenville, MS to Auburn, MS, road signs begin pointing toward Sherman along the way.
Sherman
| Road | Distance | Duration |
|---|---|---|
| US 278 | 92.3 mi | 1h 57m |
| US 61 | 64.4 mi | 1h 18m |
| I 22 | 12.7 mi | 13m |
| MS 9 | 9.8 mi | 11m |
| MS 182 | 8.7 mi | 12m |
| South Broad Street | 1.4 mi | 2m |
| Auburn Road | 0.9 mi | 2m |
| Main Street | 0.9 mi | 2m |
Step-by-step road directions between Greenville, MS and Auburn, MS.
Start on MS 814
Turn left onto Main Street
Turn left onto MS 182
Turn left onto South Broad Street
Turn straight onto Old Hwy 61
At end of road, turn right onto Griffin Road
Turn left onto US 61; US 278
Take the exit onto US 278
Keep slight right at fork onto US 278
Take the exit
Keep slight left at fork
Turn left onto MS 9
Take the exit
Merge onto I 22; US 78
Take the exit
Keep slight left at fork
Turn left onto CR 931
Turn right onto County Road 1438
Arrive at destination
To make the most of your 4-hour and 5-minute trek, consider planning for at least one dedicated stop to break up the monotony of the highway. Since the route is efficient, you have the flexibility to depart whenever suits your schedule, though leaving early helps ensure you arrive in Auburn well before nightfall. Keep an eye on your fuel gauge during the longer stretches, as the $29 budget is a baseline estimate that can fluctuate depending on your vehicle's efficiency. With only one recommended stop, use that time to stretch your legs effectively before tackling the remainder of the 192.9-mile distance. Staying mindful of the 92.3-mile segment on US 278 will help you time your breaks for maximum comfort.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 42m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 96.4 miles or 2h 3m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 22m
Traffic, exits, and arrival timing usually matter more near Auburn, MS than in the middle of the route.
Open the route before leaving Greenville, MS so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Greenville, MS
This is one driving day of about 192.9 miles and 4h 5m.
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 96.4 mi from Greenville, MS · 2h 3m into the drive
Mid-route town
Meal stop
96 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 80 miles helps settle the day before fatigue starts building.
The midpoint is around 96.4 miles from Greenville, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before US 278 if your tank is already low. That segment runs about 92.3 miles.
The final approach into Auburn, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around Auburn, MS.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Regular Gas
$29.49 one way
$58.98 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.26 | $32.34 | $64.69 |
| premium | $4.61 | $35.01 | $70.02 |
| diesel | $5.64 | $42.86 | $85.71 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$29
Meals
$25–$50
Total
$54–$79
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 67.5 kg one way. Prices: EIA weekly data, 2026-04-06.
Driving Electric?
About $20 in charging · 0 stops · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 57.9 | 0 | $20.25 | $9.26 |
| Efficient EV | 48.2 | 0 | $16.88 | $7.72 |
| EV Truck/SUV | 77.2 | 0 | $27.01 | $12.35 |
Gas CO2
67 kg
EV CO2
23 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive. If you're planning ahead, check the forecast closer to your travel date.
Origin
Late night in Greenville on Sunday
Local time
3:57 AM
CDT
Current temp
67°F
Forecast unavailable right now
Destination
Late night in Auburn on Sunday
Local time
3:57 AM
CDT
Current temp
64°F
Forecast unavailable right now
Along the Route
64°F
Memphis, TN
96 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
An early start around 7-8 AM gets you there with plenty of daylight left.
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