Origin
Tupelo, MS
Late night in Tupelo on Friday
Local time
5:57 AM
CDT
Current temp
78°F
Unavailable
Live forecast
Trip from Tupelo, MS to De Lisle, MS
Compiled and reviewed by the Trip.ovh planning team at COD Solutions Oy · Last reviewed Apr 17, 2026 · Editorial standards
Drive Time
6h 2m
Distance
309.7 mi
498 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$47
one way
EV Charging
Unknown
Best Time to Leave
4 AM
5h 50m
★
6 AM
6h 3m
8 AM
6h 29m
10 AM
6h 12m
12 PM
6h 9m
3 PM
6h 13m
5 PM
6h 27m
8 PM
5h 55m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Tupelo, MS
Wikimedia Commons
De Lisle, MS
Donatello Trisolino
Trip Overview
Embarking on a journey from Tupelo, MS to De Lisle, MS covers approximately 309.7 miles, with an estimated driving time of 6 hours and 2 minutes. This drive is best suited for a single day, making it a manageable road trip without requiring an overnight stop. You'll primarily navigate on I-59, US Highway 45 Alternate, and US 49, with highways making up 95% of the route. Expect a fuel cost around $47 for this trip. The drive flows smoothly through the Southeast region, offering a straightforward highway-focused experience.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
154.9 miles from Tupelo, MS
A natural place for your longest stop of the day , about 3h 2m into the drive .
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 2m. Total distance: 309.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 2m drive, plan rest stops for pacing.
Drive Character
This route is predominantly a highway-focused drive, with 95% of your journey taking place on major roadways. You'll encounter the longest uninterrupted stretch of 88.7 miles on I-59, which sets a consistent pace for a significant portion of the trip. While largely interstate, the inclusion of US Highway 45 Alternate and US 49 offers slight variations in the driving experience. Overall, expect a clear path with limited deviations, making for an efficient travel day.
Most of the miles stay on highways, which makes pacing and fuel planning easier than turn-by-turn city driving.
There are about 33 navigation steps in the underlying route data, so the final approach matters more than the middle miles.
I 59 is the longest continuous segment at about 88.7 miles.
How Hard Is This Drive?
This is a straightforward highway drive that stays mostly on I 59 and US Highway 45 Aiternate. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 147 miles in near I 59.
Driving Effort
9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 309.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 147 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 235.7 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 238.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Critical Maneuvers
5 of 19 key pointsThese are the spots where you need to pay the most attention. Preview them before you drive.
8
147 mi into trip
|
~2h 54m in
|
I 59
Keep slight left at fork onto I 59 toward I 59 South: Laurel, New Orleans
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 59 South: Laurel, New Orleans
7
235.7 mi into trip
|
~4h 30m in
|
US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
238.9 mi into trip
|
~4h 34m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
239.2 mi into trip
|
~4h 35m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
6
239.4 mi into trip
|
~4h 35m in
|
US 49
Turn right onto US 49
Lane positioning matters here
Use the straight lane.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Tupelo, MS and De Lisle, MS, road signs point toward New Orleans, Mobile, Gulfport, Mississippi Gulf Coast, Multi Purpose Center and Hattiesburg.
New Orleans
147 mi in
|
~2h 54m
|
via I 59
Mobile
235.7 mi in
|
~4h 30m
|
via US 98
Gulfport
238.9 mi in
|
~4h 34m
Mississippi Gulf Coast
238.9 mi in
|
~4h 34m
Multi Purpose Center
239.2 mi in
|
~4h 35m
Hattiesburg
239.2 mi in
|
~4h 35m
Main Roads
| Road | Distance | Duration |
|---|---|---|
| I 59 | 88.7 mi | 1h 36m |
| US Highway 45 Aiternate | 60.6 mi | 1h 9m |
| US 49 | 57.6 mi | 1h 8m |
| US Highway 45 Alternate | 54.7 mi | 1h 6m |
| I 10 | 8.9 mi | 9m |
| Martin Luther King Drive | 8.7 mi | 10m |
| I 20 | 8.1 mi | 9m |
| US 45 ALT | 7.2 mi | 8m |
Longest stretch:
I 59
— 88.7 mi, about 1h 36m
Turn-by-Turn Driving Directions
Step-by-step road directions between Tupelo, MS and De Lisle, MS.
1
Start on North Spring Street
68 ft
·
5 sec
·
North Spring Street
2
Turn right onto Court Street
317 ft
·
16 sec
·
Court Street
3
Turn right onto North Front Street
287 ft
·
15 sec
·
North Front Street
4
Turn left onto East Main Street
0.5 mi
·
1 min
·
East Main Street
Use the left lane.
5
Take the ramp
0.4 mi
·
55 sec
6
Merge onto US 45; MS 6
1.0 mi
·
1 min
·
Martin Luther King Drive
7
Continue on US 45; MS 6
2.3 mi
·
2 min
·
Martin Luther King, Junior Drive
8
Continue on US 45; US 278
7.7 mi
·
8 min
·
Martin Luther King Drive
9
Continue on US 45 ALT
1.4 mi
·
1 min
·
US 45 ALT
10
Continue on US 45 ALT
2.2 mi
·
2 min
·
US 45 ALT
11
Continue on US 45 ALT
1.5 mi
·
1 min
·
US 45 ALT
12
Continue on US 45 ALT
0.7 mi
·
49 sec
·
US 45 ALT
13
Continue on US 45 ALT
1.4 mi
·
1 min
·
US 45 ALT
14
Continue on US 45 ALT
55 mi
·
1 hr 6 min
·
US Highway 45 Alternate
Use the straight lane.
15
Continue on US 45
61 mi
·
1 hr 9 min
·
US Highway 45 Aiternate
16
Keep slight right at fork onto US 45
3.9 mi
·
4 min
·
US 45
17
Take the exit
0.5 mi
·
1 min
Toward I 59 South, I 20 West: Meridian
18
Merge onto I 20; I 59
6.3 mi
·
7 min
·
I 20; I 59
Use the straight / slight right lanes.
19
Continue on I 20; I 59; US 80
1.8 mi
·
2 min
·
I 20; I 59; US 80
Use the straight lane.
20
Keep slight left at fork onto I 59
89 mi
·
1 hr 36 min
·
I 59
Toward I 59 South: Laurel, New Orleans
Use the slight left / slight right lanes.
21
Take the exit onto US 98
3.2 mi
·
4 min
·
US 98
Toward US 98 East: Lucedale, Mobile
Use the straight / slight right lanes.
22
Take the exit
0.3 mi
·
44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Use the straight / slight right lanes.
23
Keep slight left at fork
0.2 mi
·
27 sec
Toward Multi Purpose Center, Hattiesburg
Use the slight left / slight right lanes.
24
Turn right onto US 49
58 mi
·
1 hr 8 min
·
US 49
Use the straight lane.
25
Take the exit
0.5 mi
·
58 sec
Toward I 10 West: New Orleans
26
Merge onto I 10
8.9 mi
·
9 min
·
I 10
27
Take the exit
0.3 mi
·
36 sec
Toward Menge Avenue
28
Keep slight left at fork
128 ft
·
4 sec
29
Turn left onto Firetower Road
224 ft
·
4 sec
·
Firetower Road
30
Continue on Menge Avenue
1.5 mi
·
3 min
·
Menge Avenue
31
Turn right onto Cuevas-Delisle Road
1.6 mi
·
3 min
·
Cuevas-Delisle Road
32
Turn left onto Ball Park Road
69 ft
·
3 sec
·
Ball Park Road
33
Arrive at destination
Ball Park Road
Trip Plan
To make the most of this 6-hour drive, consider an early morning departure from Tupelo to avoid potential traffic. With only one recommended stop, you have flexibility in pacing your journey; however, keep in mind the longest stretch is nearly 89 miles, so plan accordingly. The fuel cost is estimated at $47, so ensure your tank is full before leaving Tupelo, as services can be more spread out on highway stretches. Given the route's highway-centric nature, staying alert for speed limit changes and any potential construction on I-59, US 45 Alternate, or US 49 is advisable.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 154.9 miles from Tupelo, MS, or about 3h 2m into the drive.
The longest continuous stretch on this route runs about 88.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 68 miles or 1h 22m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 154.9 miles or 3h 2m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 53m
Traffic, exits, and arrival timing usually matter more near De Lisle, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Tupelo, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Tupelo, MS
This is one driving day of about 309.7 miles and 6h 2m.
Your first comfortable stop window is around 68 miles from Tupelo, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 59 for about 88.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Halfway Point
Midpoint
About 154.9 mi from Tupelo, MS · 3h 2m into the drive
Mid-route town
Meal stop
155 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 68 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 154.9 miles from Tupelo, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before I 59 if your tank is already low. That segment runs about 88.7 miles.
Arriving in De Lisle, MS
The final approach into De Lisle, MS usually feels slower than the middle of the drive, so avoid planning your tightest schedule at the very end.
Try to arrive with enough fuel left to skip an immediate station stop unless you already know the area around De Lisle, MS.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Fuel & Cost
Regular Gas
$46.77 one way
$93.54 round trip
$3.84/gal
25.4 MPG avg
108 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.21 | $51.34 | $102.69 |
| premium | $4.56 | $55.59 | $111.17 |
| diesel | $5.61 | $68.38 | $136.76 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$47
Meals
$25–$50
Total
$72–$97
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 108.4 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $33 in charging · 1 stop · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 92.9 | 1 | $32.52 | $14.87 |
| Efficient EV | 77.4 | 0 | $27.10 | $12.39 |
| EV Truck/SUV | 123.9 | 1 | $43.36 | $19.82 |
Gas CO2
108 kg
EV CO2
36 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
De Lisle, MS
Late night in De Lisle on Friday
Local time
5:57 AM
CDT
Current temp
63°F
Unavailable
Live forecast
79°F
Newton, MS
155 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
15 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 2m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
Frequently Asked Questions
The drive from Tupelo, MS to De Lisle, MS covers 309.7 miles and takes about 6h 2m without stops. Add 15-30 minutes for a fuel or rest stop on longer drives.
The main roads are I 59, US Highway 45 Aiternate, US 49. Most of the drive stays on highways, so watch for ramps and exits.
This is a comfortable same-day trip.
The midpoint is about 154.9 miles from Tupelo, MS. Look for rest areas, gas stations, or food options near the halfway mark.
At current regular gas prices, expect to spend about $46.77 one way. This estimate uses 25.4 MPG — your actual cost will vary with your vehicle's fuel efficiency and current gas prices.
Start early — leave by 6-7 AM to arrive at a reasonable hour. This is a long drive — plan for a morning departure or consider splitting it into two days.
Plan about 1 meaningful break for fuel, food, or rest. Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
This is a demanding drive. With 19 significant decision points across 309.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
The main spots that need attention: at 147 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 235.7 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 238.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Between Tupelo, MS and De Lisle, MS, road signs point toward New Orleans, Mobile, Gulfport, Mississippi Gulf Coast, Multi Purpose Center and Hattiesburg.
How this page is built
Compiled and maintained by the Trip.ovh planning team at COD Solutions Oy (Helsinki). Each route is built from authoritative open government and mapping datasets rather than crowdsourced reviews. Distances and geometry come from OSRM over OpenStreetMap. Fuel cost uses EIA weekly regional averages. Pages are published only after passing our data-quality checks; our methodology page documents refresh cadence, editorial standards, and known limitations.
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